Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Arnold Spek"'
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-14 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges due to the inadequacy of existing chemotherapeutics, which often result in toxicity-dependent dose limitations and premature cessation of therapy. Targeted delivery of t
Externí odkaz:
https://doaj.org/article/21affa4ad5fa4ab093c47cbbe4cb4702
Autor:
Sarah Loubele, Arnold Spek, Peter Leenders, R A Matthijsen, Wim Buurman, carine peutz-kootstra, Hugo ten Cate, Henri Spronk
Publikováno v:
ScienceOpen Research (2014)
Renal ischemia/reperfusion (I/R) injury is the main cause of acute renal failure. The severity of injury is determined by endothelial damage as well as inflammatory and apoptotic processes. The anti-coagulants active site inhibited factor VIIa (ASIS)
Externí odkaz:
https://doaj.org/article/65a598f682fb4ec685583e0e3d115db0
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and severe disease characterized by excessive matrix deposition in the lungs. Macrophages play crucial roles in maintaining lung homeostasis but are also central in the
Externí odkaz:
https://doaj.org/article/c5b7c0e436bb4f81b2d2c86b9d92d80e
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a grim disease with high mortality rates. Increased macrophage influx in PDAC is a common hallmark and associated with poor prognosis. Macrophages have high cellular plasticity, which can
Externí odkaz:
https://doaj.org/article/73d1e99142ce41bc93e5c3bcd4de4616
Autor:
Leonie Hartl, Pien A. F. Maarschalkerweerd, Joe M. Butler, Xue D. Manz, Victor L. J. L. Thijssen, Maarten F. Bijlsma, JanWillem Duitman, C. Arnold Spek
Publikováno v:
Cells, Vol 11, Iss 21, p 3334 (2022)
Pancreatic Ductal Adenocarcinoma (PDAC) is among the most aggressive human cancers and occurs globally at an increasing incidence. Metastases are the primary cause of cancer-related death and, in the majority of cases, PDAC is accompanied by metastat
Externí odkaz:
https://doaj.org/article/c40525e5847b4102add33b8dc3094fbd
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 219 (2022)
Treatment of pancreatic ductal adenocarcinoma (PDAC), a dismal disease with poor survival rates, is hampered by the high prevalence of chemotherapy resistance. Resistance is accompanied by macrophage infiltration into the tumor microenvironment, and
Externí odkaz:
https://doaj.org/article/1c8065e6b82f41c1bf4788f4fc6063fc
Publikováno v:
Cells, Vol 10, Iss 9, p 2233 (2021)
CCAAT/enhancer-binding protein delta (C/EBPδ) is a member of the C/EBP family of transcription factors. According to the current paradigm, C/EBPδ potentiates cytokine production and modulates macrophage function thereby enhancing the inflammatory r
Externí odkaz:
https://doaj.org/article/7ab27c72921a40d9a26295346fef8aea
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1079 (2021)
CCAAT/enhancer-binding protein delta (C/EBPδ) is a transcription factor involved in apoptosis and proliferation, which is downregulated in pancreatic ductal adenocarcinoma (PDAC) cells. Loss of nuclear C/EBPδ in PDAC cells is associated with decrea
Externí odkaz:
https://doaj.org/article/fbc593a762624215b2689b7d8cd45af3
Publikováno v:
Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 152-156 (2017)
Background: Protease-activated receptor-1 (PAR-1) potentiates diabetic nephropathy (DN) as evident from reduced kidney injury in diabetic PAR-1 deficient mice. Although thrombin is the prototypical PAR-1 agonist, anticoagulant treatment does not limi
Externí odkaz:
https://doaj.org/article/2269142eebfc40d99cda7074ddaeed9f
Autor:
Kun Shi, Helene Damhofer, Joost Daalhuisen, Marieke ten Brink, Dick J. Richel, C. Arnold Spek
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 13-23 (2017)
Abstract Pancreatic cancer is one of the most lethal solid malignancies, with few treatment options. We have recently shown that expression of protease activated receptor (PAR)-1 in the tumor microenvironment drives the progression and induces the ch
Externí odkaz:
https://doaj.org/article/6e50a7b861c34a498c0aed80d8226043