Výsledky vyhledávání - "Arnold S, Leonard"

Virulence-attenuated Salmonella engineered to secrete immunomodulators reduce tumour growth and increase survival in an autochthonous mouse model of breast cancer

Autor: Sara E. Hastings, Daniel A. Saltzman, Arnold S. Leonard, Liming Milbauer, Janet L. Schottel, Lance B. Augustin

Publikováno v: Journal of Drug Targeting. 29:430-438

The ultimate goal of bacterial based cancer therapy is to achieve non-toxic penetration and colonisation of the tumour microenvironment. To overcome this efficacy-limiting toxicity of anticancer im...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cf867f9e5b33faccb8d1e3ae09a0ff2
https://doi.org/10.1080/1061186x.2020.1850739

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Salmonella enterica Typhimurium engineered for nontoxic systemic colonization of autochthonous tumors

Autor: Arnold S. Leonard, Lance B. Augustin, Daniel A. Saltzman, Sara E. Hastings, Liming Milbauer, Janet L. Schottel

Publikováno v: Journal of Drug Targeting. 29:294-299

Much of the bacterial anticancer therapy being developed relies on the ability of bacteria to specifically colonise tumours. Initial attempts to translate promising Salmonella enterica Typhimurium ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c616e6c360ffacc11e24164f120614e
https://doi.org/10.1080/1061186x.2020.1818759

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A Phase I, Dose Escalation, Single Dose Trial of Oral Attenuated Salmonella typhimurium Containing Human IL-2 in Patients With Metastatic Gastrointestinal Cancers

Autor: Daniel A. Saltzman, Lance B. Augustin, Thomas J. Gniadek, Gerald Batist, Edward W Greeno, Arnold S. Leonard, Janet L. Schottel

Publikováno v: Journal of Immunotherapy (Hagerstown, Md. : 1997)

Salmonella has been shown to preferentially colonize solid tumors. It is known that toxicity limits the systemic administration of immunomodulatory cytokines that have a significant anticancer effect. Therefore, we tested a unique cancer treatment st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd53458e70f3ad4603e88afa628772a4
https://doi.org/10.1097/cji.0000000000000325

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Virulence-attenuated

Autor: Lance B, Augustin, Liming, Milbauer, Sara E, Hastings, Arnold S, Leonard, Daniel A, Saltzman, Janet L, Schottel

Publikováno v: Journal of drug targeting. 29(4)

The ultimate goal of bacterial based cancer therapy is to achieve non-toxic penetration and colonisation of the tumour microenvironment. To overcome this efficacy-limiting toxicity of anticancer immunotherapy, we have tested a therapy comprised of sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2e27c754a2db7c0369e47ffccc5c6ee
https://pubmed.ncbi.nlm.nih.gov/33183080

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Low dose chemotherapy combined with attenuated Salmonella decreases tumor burden and is less toxic than high dose chemotherapy in an autochthonous murine model of breast cancer

Autor: Daniel A. Saltzman, Janet L. Schottel, Michael J. Mertensotto, Arnold S. Leonard, Lance B. Augustin

Publikováno v: Surgery. 163:509-514

Immunotherapies for cancer treatment have demonstrated substantial promise even though toxicities and development of tumor resistance limit their effectiveness. A combinatorial approach using immunotherapy with other treatment modalities may decrease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2be883970f4b71bc1a49240b96e4fa
https://doi.org/10.1016/j.surg.2017.09.036

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Attenuated Salmonella typhimurium with IL-2 Gene Reduces Pulmonary Metastases in Murine Osteosarcoma

Autor: Arnold S. Leonard, Natalie L. Frykman, Brent S. Sorenson, Daniel A. Saltzman, Kaysie L. Banton

Publikováno v: Clinical Orthopaedics & Related Research. 466:1285-1291

Historically, osteosarcoma has been a problematic metastatic disease, with 40-80% of patients developing pulmonary metastasis after primary tumor resection. Recent treatment advancements have reduced the occurrence of metastatic lesions to less than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1175b600c2667700c9a6c22fbd5e13a4
https://doi.org/10.1007/s11999-008-0243-2

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Attenuated Salmonella typhimurium invades and decreases tumor burden in neuroblastoma

Autor: Arnold S. Leonard, Daniel A. Saltzman, Sean J. Barnett, Leland J. Soto, Brent W. Nelson, Brent S. Sorenson

Publikováno v: Journal of Pediatric Surgery. 40:993-998

Introduction We have previously shown that Salmonella elicits an antitumor response against hepatic adenocarcinomatous metastases. In vitro studies have demonstrated both intracellular invasion and proliferation of Salmonella within cultured neurobla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1492551c744f0829d1ae6243747a4df4
https://doi.org/10.1016/j.jpedsurg.2005.03.015

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Liver and Circulating NK1.1+CD3− Cells Are Increased in Infection with Attenuated Salmonella typhimurium and Are Associated with Reduced Tumor in Murine Liver Cancer

Autor: Carol L. Wells, Adam S. Kim, Daniel A. Saltzman, Arnold S. Leonard, D. A. Sahar, Jeffrey S. Miller, Timothy D. Sielaff, Brad A. Feltis

Publikováno v: Journal of Surgical Research. 107:101-107

An attenuated (DeltacyA, Deltacrp) strain of Salmonella typhimurium (chi4550) containing a gene for human IL-2 (chi4550pIL2) reduces hepatic tumor burden when orally inoculated into mice with liver cancer; however, wild-type S. typhimurium is also as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc581d8e789ae3055eae1bd4ce8851f0
https://doi.org/10.1006/jsre.2002.6428

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