Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Arnold R, Gammaitoni"'
Publikováno v:
Epilepsia Open, Vol 9, Iss 1, Pp 300-313 (2024)
Abstract Objective In patients with Dravet syndrome (DS), fenfluramine reduced convulsive seizure frequency and provided clinical benefit in nonseizure endpoints (e.g., executive function, survival). In zebrafish mutant scn1 DS models, chronic fenflu
Externí odkaz:
https://doaj.org/article/2b6507ecce2d48699f0a03d19bb7e3d3
Autor:
Dagmar Amtmann, Alyssa M. Bamer, Rana Salem, Arnold R. Gammaitoni, Bradley S. Galer, Mark P. Jensen
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 5, Iss 1, Pp 1-7 (2021)
Abstract Background English versions of the University of Washington Caregiver Stress (UW-CSS) and Benefit (UW-CBS) Scales were developed in the United States (US) to measure impact on caregivers of caring for a child/children. Caregiving stress and
Externí odkaz:
https://doaj.org/article/dd34785cd77c47af824f360219c46ed0
Publikováno v:
Mitochondrion. 68:1-9
TK2d is an ultrarare autosomal recessive mitochondrial DNA depletion syndrome. Nucleoside therapy improves or stabilizes disease across key outcomes including survival, ambulation, and requirement for mechanical ventilation. However, little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9415ed82ae3b3b54234d723d29fd9bf9
https://doi.org/10.1016/j.mito.2022.10.003
https://doi.org/10.1016/j.mito.2022.10.003
Autor:
Bradley S. Galer, Elizabeth J. Donner, Sanjeev V. Kothare, Elaine C. Wirrell, An-Sofie Schoonjans, Antonio Gil-Nagel, J. Helen Cross, Michael Lock, Berten Ceulemans, Orrin Devinsky, Lieven Lagae, Arnold R. Gammaitoni, Anupam Agarwal
Publikováno v:
Seizure: European journal of epilepsy
PURPOSE: To assess the impact of fenfluramine (FFA) on the expected mortality incidence, including sudden unexpected death in epilepsy (SUDEP), in persons with Dravet syndrome (DS). METHODS: In this pooled analysis, total time of exposure for persons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75835983609b945b84537f7bf55a21b
https://doi.org/10.1016/j.seizure.2021.10.024
https://doi.org/10.1016/j.seizure.2021.10.024
Autor:
M. Scott Perry, Stéphane Auvin, Bradley S. Galer, Orrin Devinsky, Arnold R. Gammaitoni, Nicola Specchio, Adam Strzelczyk, David Dai, Joseph Sullivan, Antonio Gil-Nagel
Publikováno v:
Epilepsia. 63:130-138
OBJECTIVE The number, unpredictability, and severity of seizures experienced by patients with Dravet syndrome (DS) negatively impact quality of life (QOL) for patients, caregivers, and families. Metrics are needed to assess whether patients with resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7eab0fe5141f6c2f028364f9144526d
https://doi.org/10.1111/epi.17106
https://doi.org/10.1111/epi.17106
Autor:
Kim I. Bishop, Peter K. Isquith, Gerard A. Gioia, Kelly G. Knupp, Ingrid E. Scheffer, Rima Nabbout, Nicola Specchio, Joseph Sullivan, Stéphane Auvin, J. Helen Cross, Renzo Guerrini, Gail Farfel, Bradley S. Galer, Arnold R. Gammaitoni
Publikováno v:
Epilepsybehavior : EB. 138
To evaluate whether fenfluramine (FFA) is associated with improvement in everyday executive function (EF)-self-regulation-in preschool-aged children with Dravet syndrome (DS).Children with DS received placebo or FFA in one of two phase III studies (f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2f7ab2fdda5badeec84cbbcd0319a7
https://pubmed.ncbi.nlm.nih.gov/36463826
https://pubmed.ncbi.nlm.nih.gov/36463826
Autor:
Mark P. Jensen, Arnold R. Gammaitoni, Bradley S. Galer, Rana Salem, Dana Wilkie, Dagmar Amtmann
Publikováno v:
Epilepsy research. 185
Prior research has demonstrated durable and profound reductions in seizure frequency and improvements in executive functions in individuals with Dravet syndrome (DS) who are treated with fenfluramine (FFA). This study aimed to understand the benefits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb0ee4901ab7bed61c32820ab5bacbc
https://pubmed.ncbi.nlm.nih.gov/35843016
https://pubmed.ncbi.nlm.nih.gov/35843016
Autor:
Kelly G. Knupp, Ingrid E. Scheffer, Berten Ceulemans, Joseph E. Sullivan, Katherine C. Nickels, Lieven Lagae, Renzo Guerrini, Sameer M. Zuberi, Rima Nabbout, Kate Riney, Svetlana Shore, Anupam Agarwal, Michael Lock, Gail M. Farfel, Bradley S. Galer, Arnold R. Gammaitoni, Ronald Davis, Antonio Gil-Nagel
Publikováno v:
JAMA neurology
IMPORTANCE: New treatment options are needed for patients with Lennox-Gastaut syndrome (LGS), a profoundly impairing, treatment-resistant, developmental and epileptic encephalopathy. OBJECTIVE: To evaluate the efficacy and safety of fenfluramine in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890f47c2b632f50d1d98dce3cbd7fcb7
https://pubmed.ncbi.nlm.nih.gov/35499850
https://pubmed.ncbi.nlm.nih.gov/35499850
Autor:
Dagmar Amtmann, Mark P. Jensen, Arnold R. Gammaitoni, Carey R. Aron, Alyssa M. Bamer, Bradley S. Galer, Kendra Liljenquist
Publikováno v:
Quality of Life Research. 29:1361-1371
To develop item response theory (IRT)-based item banks and short forms to measure stress and benefit related to caregiving for children, including children with epilepsy or other serious health conditions. Items developed with feedback from neurologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947572119f802810ec7c3c77e00ffa1d
https://doi.org/10.1007/s11136-019-02409-0
https://doi.org/10.1007/s11136-019-02409-0
Publikováno v:
Epilepsy Research. 190:107091
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3fa8629870143ec348cb34d75816eca
https://doi.org/10.1016/j.eplepsyres.2023.107091
https://doi.org/10.1016/j.eplepsyres.2023.107091