Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Arnold Park"'
Autor:
Michael R. McAllaster, Jaya Bhushan, Dale R. Balce, Anthony Orvedahl, Arnold Park, Seungmin Hwang, Meagan E. Sullender, L. David Sibley, Herbert W. Virgin
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTGenes required for the lysosomal degradation pathway of autophagy play key roles in topologically distinct and physiologically important cellular processes. Some functions of ATG genes are independent of their role in degradative autophagy. O
Externí odkaz:
https://doaj.org/article/ee73c35548d94fc394c27a7238cc9bbd
Autor:
Satoshi Ikegame, Shannon M Beaty, Christian Stevens, Taylor Won, Arnold Park, David Sachs, Patrick Hong, Benhur Lee, Patricia A Thibault
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008877 (2020)
The antigenic and genomic stability of paramyxoviruses remains a mystery. Here, we evaluate the genetic plasticity of Sendai virus (SeV) and mumps virus (MuV), sialic acid-using paramyxoviruses that infect mammals from two Paramyxoviridae subfamilies
Externí odkaz:
https://doaj.org/article/c4fa34d2d8c24fb08f8972c939d22f10
Autor:
Shannon M. Beaty, Arnold Park, Sohui T. Won, Patrick Hong, Michael Lyons, Frederic Vigant, Alexander N. Freiberg, Benjamin R. tenOever, W. Paul Duprex, Benhur Lee
Publikováno v:
mSphere, Vol 2, Iss 2 (2017)
ABSTRACT The notoriously low efficiency of Paramyxoviridae reverse genetics systems has posed a limiting barrier to the study of viruses in this family. Previous approaches to reverse genetics have utilized a wide variety of techniques to overcome th
Externí odkaz:
https://doaj.org/article/9ed5da7edaf44f2b8d23894e3de833c7
Autor:
Preeti Bharaj, Yao E Wang, Brian E Dawes, Tatyana E Yun, Arnold Park, Benjamin Yen, Christopher F Basler, Alexander N Freiberg, Benhur Lee, Ricardo Rajsbaum
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005880 (2016)
For efficient replication, viruses have developed mechanisms to evade innate immune responses, including the antiviral type-I interferon (IFN-I) system. Nipah virus (NiV), a highly pathogenic member of the Paramyxoviridae family (genus Henipavirus),
Externí odkaz:
https://doaj.org/article/ba0da777b7ea4d80b4ea6b3307a3d2e3
Autor:
Arnold Park, Tatyana Yun, Frederic Vigant, Olivier Pernet, Sohui T Won, Brian E Dawes, Wojciech Bartkowski, Alexander N Freiberg, Benhur Lee
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005659 (2016)
The budding of Nipah virus, a deadly member of the Henipavirus genus within the Paramyxoviridae, has been thought to be independent of the host ESCRT pathway, which is critical for the budding of many enveloped viruses. This conclusion was based on t
Externí odkaz:
https://doaj.org/article/bfbaab4065724a789412a8a68380ffcd
Autor:
Arnold Park, Patrick Hong, Sohui T Won, Patricia A Thibault, Frederic Vigant, Kasopefoluwa Y Oguntuyo, Justin D Taft, Benhur Lee
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
The advent of RNA-guided endonuclease (RGEN)-mediated gene editing, specifically via CRISPR/Cas9, has spurred intensive efforts to improve the efficiency of both RGEN delivery and targeted mutagenesis. The major viral vectors in use for delivery of C
Externí odkaz:
https://doaj.org/article/a47e9ef0babb4529a61546002c818f9a
Autor:
Peter B. Rupert, Meei-Li Huang, Haiying Zhu, Andrew Fiore-Gartland, Arnold Park, Colleen McLaughlin, Chance Brock, April K. Randhawa, Roland K. Strong, Maurine D. Miner, Yixuan J. Hou, Matthew Buerger, Ralph S. Baric, Emily S Ford, Leonidas Stamatatos, Anton M Sholukh, Hannah Kaiser, Russell St Germain, Florian A. Lempp, Keith R. Jerome, Andrew B. Stuart, Joyce Y C Lu, Emily L Bossard, Bhanupriya Madarampalli, Margaret K. Doll, Jia Jin Kee, Kurt Diem, Lawrence Corey, Longping V. Tse, David C. Montefiori
Publikováno v:
Journal of Clinical Microbiology
Determinants of protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection require the development of well-standardized, reproducible antibody assays. This need has led to the emergence of a variety of neutrali
Autor:
Mickey Pentecost, Ajay A Vashisht, Talia Lester, Tim Voros, Shannon M Beaty, Arnold Park, Yao E Wang, Tatyana E Yun, Alexander N Freiberg, James A Wohlschlegel, Benhur Lee
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004739 (2015)
The paramyxovirus matrix (M) protein is a molecular scaffold required for viral morphogenesis and budding at the plasma membrane. Transient nuclear residence of some M proteins hints at non-structural roles. However, little is known regarding the mec
Externí odkaz:
https://doaj.org/article/e0e16e96e7c14b2eb3f3d427fa4a45e5
Autor:
Seungmin Hwang, Herbert W. Virgin, Sibley Ld, Michael R. McAllaster, Jaya Bhushan, Dale R. Balce, Anthony Orvedahl, Arnold Park, Meagan E Sullender
Genes required for the lysosomal degradation pathway of autophagy play key roles in topologically distinct cellular processes with significant physiologic importance. One of the first-described of these ATG gene-dependent processes is the requirement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5620eee3ad93f48556e60afad80134bb
https://doi.org/10.1101/2021.05.10.443539
https://doi.org/10.1101/2021.05.10.443539
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95101 (2014)
Although modulation of protein levels is an important tool for study of protein function, it is difficult or impossible to knockdown or knockout genes that are critical for cell growth or viability. For such genes, a conditional knockdown approach wo
Externí odkaz:
https://doaj.org/article/761a8b9f97be4e209a57f2fac44e88f9