Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma.

Autor: Arnold MR; Medical Scientist Training Program, Oregon Health and Science University, Portland, OR, USA.; Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA., Cohn GM; Department of Molecular and Medical Genetics, School of Medicine, Oregon Health and Science University, Portland, OR, USA., Oxe KC; Danish Cancer Institute, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark., Elliott SN; Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA., Moore C; Research Services, Neurocytology Laboratory, Veterans Affairs Medical Center, Portland, OR, USA., Laraia PV; Independent Collaborator., Shekoohi S; Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, USA., Brownell D; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA., Meshul CK; Research Services, Neurocytology Laboratory, Veterans Affairs Medical Center, Portland, OR, USA.; Departments of Behavioral Neuroscience and Pathology, Oregon Health and Science University, Portland, OR, USA., Witt SN; Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, USA., Larsen DH; Danish Cancer Institute, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark., Unni VK; Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA.; OHSU Parkinson's Center, Oregon Health and Science University, Portland, OR, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 14. Date of Electronic Publication: 2024 Jan 14.

Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.

Autor: Arnold MR; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA., Langelier MF; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Gartrell J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Kirby IT; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA., Sanderson DJ; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA., Bejan DS; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA., Šileikytė J; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA., Sundalam SK; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA., Nagarajan S; Medicinal Chemistry Core, Oregon Health & Science University, Portland, OR 97210, USA., Marimuthu P; Structural Bioinformatics Laboratory, Åbo Akademi University, Faculty of Science and Engineering, 20520 Turku, Finland., Duell AK; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA., Shelat AA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Cohen MS; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA. Electronic address: cohenmic@ohsu.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2022 Dec 15; Vol. 29 (12), pp. 1694-1708.e10. Date of Electronic Publication: 2022 Dec 08.

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium.

Autor: Scott GD; Department of Pathology, Oregon Health and Science University, Portland, OR, United States.; Department of Pathology and Laboratory Services, VA Portland Medical Center, Portland, OR, United States., Arnold MR; Graduate Program in Biomedical Sciences, School of Medicine M.D./Ph.D. Program, Oregon Health and Science University, Portland, OR, United States., Beach TG; Civin Laboratory for Neuropathology and Brain and Body Donation Program, Banner Sun Health Research Institute, Sun City, AZ, United States., Gibbons CH; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States., Kanthasamy AG; Department of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States., Lebovitz RM; Amprion Inc., San Francisco, CA, United States., Lemstra AW; Department of Neurology, Amsterdam University Medical Center (UMC), Alzheimer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Shaw LM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Zetterberg H; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London, United Kingdom.; UK Dementia Research Institute at University College London, London, United Kingdom.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China., Taylor AS; Lewy Body Dementia Association, Lilburn, GA, United States., Graham TC; Lewy Body Dementia Association, Lilburn, GA, United States., Boeve BF; Department of Neurology and Center for Sleep Medicine, Mayo Clinic, Rochester, MN, United States., Gomperts SN; Department of Neurology, Massachusetts General Hospital, Boston, MA, United States., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, FL, United States., Moussa C; Department of Neurology, Georgetown University Medical Center, Washington DC, CA, United States., Poston KL; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States., Rosenthal LS; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States., Sabbagh MN; Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, United States., Walsh RR; Barrow Neurological Institute and Muhammed Ali Parkinson Center, Phoenix, AZ, United States., Weber MT; Department of Neurology, University of Rochester, Rochester, NY, United States., Armstrong MJ; Department of Neurology, University of Florida College of Medicine, Gainesville, FL, United States., Bang JA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Bozoki AC; Department of Neurology, University of North Carolina, Chapel Hill, NC, United States., Domoto-Reilly K; Department of Neurology, University of Washington, Seattle, WA, United States., Duda JE; Parkinson's Disease Research, Education and Clinical Center, Michael J. Crescenz VA Medical Center, Philadelphia, PA, United States.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Fleisher JE; Department of Neurological Sciences, Rush Medical College, Chicago, IL, United States., Galasko DR; Department of Neurosciences, University of California, San Diego, San Diego, CA, United States., Galvin JE; Department of Neurology, Comprehensive Center for Brain Health, University of Miami Miller School of Medicine, Miami, FL, United States., Goldman JG; Shirley Ryan Abilitylab and Department of Physical Medicine and Rehabilitation and Neurology, Parkinson's Disease and Movement Disorders, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Holden SK; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, United States., Honig LS; Columbia University Irving Medical Center, New York, NY, United States., Huddleston DE; Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States., Leverenz JB; Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, United States., Litvan I; Department of Neurosciences, University of California, San Diego, San Diego, CA, United States., Manning CA; Department of Neurology, University of Virginia, Charlottesville, VA, United States., Marder KS; Columbia University Irving Medical Center, New York, NY, United States., Pantelyat AY; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Pelak VS; Departments of Neurology and Ophthalmology, University of Colorado School of Medicine, Aurora, CO, United States., Scharre DW; Department of Neurology, Ohio State University Wexner Medical Center, Columbus, OH, United States., Sha SJ; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States., Shill HA; Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, United States., Mari Z; Lou Ruvo Center for Brain Health, Cleveland Clinic Lerner College of Medicine, Las Vegas, NV, United States., Quinn JF; Department of Neurology, Oregon Health and Science University, Portland, OR, United States.; Department of Neurology, VA Portland Medical Center, Portland, OR, United States., Irwin DJ; Department of Neurology, University of Pennsylvania Health System, Philadelphia, PA, United States.; Digital Neuropathology Laboratory, Philadelphia, PA, United States.; Lewy Body Disease Research Center of Excellence, Philadelphia, PA, United States.; Frontotemporal Degeneration Center, Philadelphia, PA, United States.

Publikováno v: Frontiers in neurology [Front Neurol] 2022 Jan 31; Vol. 12, pp. 805135. Date of Electronic Publication: 2022 Jan 31 (Print Publication: 2021).

Genetic susceptibility to caffeine intake and metabolism: a systematic review.

Autor: Low, Jazreel Ju-Li^1,2 (AUTHOR), Tan, Brendan Jen-Wei¹ (AUTHOR), Yi, Ling-Xiao² (AUTHOR), Zhou, Zhi-Dong^1,2 (AUTHOR), Tan, Eng-King^1,2 (AUTHOR) EKL2EKL2@gmail.com

Publikováno v: Journal of Translational Medicine. 10/22/2024, Vol. 22 Issue 1, p1-28. 28p.

Effects of Immunization With the Soil-Derived Bacterium Mycobacterium vaccae on Stress Coping Behaviors and Cognitive Performance in a "Two Hit" Stressor Model.

Autor: Foxx CL; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States., Heinze JD; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States., González A; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States., Vargas F; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States.; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States., Baratta MV; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States.; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States., Elsayed AI; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States., Stewart JR; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States., Loupy KM; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States., Arnold MR; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States., Flux MC; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States., Sago SA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States., Siebler PH; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Milton LN; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Lieb MW; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Hassell JE; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States., Smith DG; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Lee KAK; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States., Appiah SA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States., Schaefer EJ; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States., Panitchpakdi M; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States.; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States., Sikora NC; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States.; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States., Weldon KC; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States.; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States., Stamper CE; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Schmidt D; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Duggan DA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Mengesha YM; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Ogbaselassie M; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Nguyen KT; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Gates CA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Schnabel K; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Tran L; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Jones JD; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Vitaterna MH; Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, IL, United States., Turek FW; Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, IL, United States., Fleshner M; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States., Dorrestein PC; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States.; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States., Knight R; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States.; Department of Computer Science and Engineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA, United States.; Department of Bioengineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA, United States., Wright KP; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States., Lowry CA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.; Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States.; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States.; Veterans Health Administration, Rocky Mountain Mental Illness Research Education and Clinical Center, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO, United States.; Military and Veteran Microbiome: Consortium for Research and Education, Aurora, CO, United States.; Department of Physical Medicine and Rehabilitation and Center for Neuroscience, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; inVIVO Planetary Health, Worldwide Universities Network, West New York, NJ, United States.

Publikováno v: Frontiers in physiology [Front Physiol] 2021 Jan 05; Vol. 11, pp. 524833. Date of Electronic Publication: 2021 Jan 05 (Print Publication: 2020).