Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor

Autor: Weitsman, G, Mitchell, NJ, Evans, R, Cheung, A, Kalber, TL, Bofinger, R, Fruhwirth, GO, Keppler, M, Wright, ZVF, Barber, PR, Gordon, P, de Koning, T, Wulaningsih, W, Sander, K, Vojnovic, B, Ameer-Beg, S, Lythgoe, M, Arnold, JN, Årstad, E, Festy, F, Hailes, HC, Tabor, AB, Ng, T

Publikováno v: Oncogene
Weitsman, G, Mitchell, N J, Evans, R, Cheung, A, Kalber, T L, Bofinger, R, Fruhwirth, G O, Keppler, M, Wright, Z V F, Barber, P R, Gordon, P, de Koning, T, Wulaningsih, W, Sander, K, Vojnovic, B, Ameer-Beg, S, Lythgoe, M, Arnold, J N, Årstad, E, Festy, F, Hailes, H C, Tabor, A B & Ng, T 2017, ' Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor ', Oncogene, vol. 36, no. 25, pp. 3618–3628 . https://doi.org/10.1038/onc.2016.522

Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested clinically, the success rate for these agents in the clinic is low, particularly in terms of the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::858fc396aef7cd23f52cb66d129a5f5a
http://ora.ox.ac.uk/objects/uuid:

Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin

Autor: Arnold, JN, Wormald, MR, Suter, DM, Radcliffe, CM, Harvey, DJ, Dwek, RA, Rudd, PM, Sim, RB

The glycoprotein IgM is the major antibody produced in the primary immune response to antigens, circulating in the serum both as a pentamer and a hexamer. Pentameric IgM has a single J chain, which is absent in the hexamer. The mu (heavy) chain of Ig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b82a22259cc65f90e210bea4a6417447
https://doi.org/10.1074/jbc.m504528200

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