Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Arnold J. Krog"'
Autor:
Mary J. Bossard, Arnold J. Krog, Hwa-Kwo Yen, Karl F. Erhard, Arda Konialian-Beck, Elizabeth Ortiz, Hye-Ja Oh, Martin Brandt, Mark Alan Levy, Dennis A. Holt, Juan I. Luengo, Leonard W. Rozamus
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:315-320
A series of non-macrocyclic pipecolyl α-ketoamides were prepared and evaluated as FKBP cis-trans peptidyl-prolyl isomerase inhibitors. These compounds exhibited inhibition constants as low as 2 nM. Their design was based on a consideration of the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1eb9ce645a5f796476c9222b28ff3fd
https://doi.org/10.1016/s0960-894x(01)80135-9
https://doi.org/10.1016/s0960-894x(01)80135-9
Autor:
Jeffrey T. Laydon, Glenn A. Hofmann, Jeffrey C. Boehm, Jeffrey W. Abt, Margaret E. Soreson, Susan M. Fier-Thompson, Juanita M. Smietana, Peter R. Young, Timothy Francis Gallagher, John C. Lee, Mary Jane Blumenthal, Arnold J. Krog, Ralph Hall, Dennis Lee, Paul Elliot Bender, Karl F. Erhard, Ravi Shanker Garigipati, Jerry L. Adams, Peter C. McDonnell, George Leslie Seibel, Shouki Kassis, Sanjay Kumar, Peter L. Sheldrake
Publikováno v:
Bioorganicmedicinal chemistry. 5(1)
Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e122df6ffe903523b617fc84550c0c
https://pubmed.ncbi.nlm.nih.gov/9043657
https://pubmed.ncbi.nlm.nih.gov/9043657
Publikováno v:
Journal of Medicinal Chemistry. 21:489-492
A series of substituted 2-arylthiazolo[3,2-a]pyridinium salts (1a-q) was prepared by known methods and tested for hypoglycemic activity in 48-h fasted rats. Two compounds, 2-phenylthiazolo- and 8-methyl-2-phenythiazolo[3,2-a]pyridinium perchlorate (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546e63de534891c4257d3a03e6db445e
https://doi.org/10.1021/jm00203a019
https://doi.org/10.1021/jm00203a019
Publikováno v:
Journal of medicinal chemistry. 23(8)
1,2,3,4-Tetrahydroisoquinoline-7-sulfonanilides (1-14) related to 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (21,SK&F 29661) were prepared and studied for their ability to inhibit phenylethanolamine N-methyltransferase (PNMT) in vitro. The choice o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d8e785e6f0b085520a46f2337067e7
https://pubmed.ncbi.nlm.nih.gov/7401111
https://pubmed.ncbi.nlm.nih.gov/7401111
Publikováno v:
Chemischer Informationsdienst. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::464e0b96986e7e44928ea8e178b85f26
https://doi.org/10.1002/chin.197950226
https://doi.org/10.1002/chin.197950226
Publikováno v:
Journal of medicinal chemistry. 22(7)
The potent hypoglycemic activity of 3-(3-methyl-2-pyridyl)propan-1-ol (1) prompted us to synthesize and study related structures. Some of the variables studied were the position of the methyl and alcohol side chains, the distance between the heterocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0671871206ee576283c70b30ca6110cd
https://pubmed.ncbi.nlm.nih.gov/448683
https://pubmed.ncbi.nlm.nih.gov/448683
Publikováno v:
Chemischer Informationsdienst. 12
1,2,3,4-Tetrahydroisoquinoline-7-sulfonanilides (1-14) related to 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (21,SK&F 29661) were prepared and studied for their ability to inhibit phenylethanolamine N-methyltransferase (PNMT) in vitro. The choice o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f3f49e70cdfcf168eacd19f423515b4
https://doi.org/10.1002/chin.198105241
https://doi.org/10.1002/chin.198105241
Publikováno v:
Chemischer Informationsdienst. 9
A series of substituted 2-arylthiazolo[3,2-a]pyridinium salts (1a-q) was prepared by known methods and tested for hypoglycemic activity in 48-h fasted rats. Two compounds, 2-phenylthiazolo- and 8-methyl-2-phenythiazolo[3,2-a]pyridinium perchlorate (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c4d4d32c902156b14a306c5c6aea06c
https://doi.org/10.1002/chin.197846264
https://doi.org/10.1002/chin.197846264