Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Arnold J. Heynen"'
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate
Externí odkaz:
https://doaj.org/article/d876a8e8eb874f5ea370bbe486d1786b
Publikováno v:
Journal of Comparative Neurology.
During a critical period of postnatal life, monocular deprivation (MD) of kittens by eyelid closure reduces the size of neurons in layers of the dorsal lateral geniculate nucleus (dLGN) connected to the deprived eye, and shifts cortical ocular domina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b388a60d0be7910c87a2ef2fb9443be
https://doi.org/10.1101/2022.08.08.503194
https://doi.org/10.1101/2022.08.08.503194
Publikováno v:
Frontiers in Psychiatry
Frontiers in Psychiatry, Vol 12 (2021)
Frontiers in Psychiatry, Vol 12 (2021)
Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate
Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd9eaf9ceed2a26bd3c85ce14adec3a4
https://doi.org/10.1101/2021.07.02.450894
https://doi.org/10.1101/2021.07.02.450894
Autor:
Jon M. Madison, Patrick K. McCamphill, David C. Stoppel, Xi Shi, Michael C. Lewis, Katie A. Collins, Mark F. Bear, Florence F. Wagner, Edward M. Scolnick, Vinay Sridhar, Rebecca K Senter, Kimberly M. Huber, Jen Q. Pan, Arnold J. Heynen, Jeffrey R. Cottrell, Laura J. Stoppel, Edward B. Holson
Publikováno v:
Sci Transl Med
PMC
PMC
Copyright © 2020 The Authors, some rights reserved. Fragile X syndrome is caused by FMR1 gene silencing and loss of the encoded fragile X mental retardation protein (FMRP), which binds to mRNA and regulates translation. Studies in the Fmr1-/y mouse
Autor:
Melanie D. Schaffler, Arnold J. Heynen, Mark F. Bear, Jacqueline N. Crawley, Tatiana M. Kazdoba, Laura J. Stoppel, Anthony R. Preza
Publikováno v:
Nature
Neuropsychopharmacology
Neuropsychopharmacology
Human chromosome 16p11.2 microdeletion is among the most common gene copy number variations (CNVs) known to confer risk for intellectual disability (ID) and autism spectrum disorder (ASD) and affects an estimated 3 in 10 000 people. Caused by a singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621e57ff53fff628a20b45446f4fd515
https://hdl.handle.net/1721.1/126513
https://hdl.handle.net/1721.1/126513
Publikováno v:
Journal of American Association for Pediatric Ophthalmology and Strabismus. 23:e29
Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion
Autor:
Mark F. Bear, Di Tian, Arnold J. Heynen, Laura J. Stoppel, Lothar Lindemann, Alea A. Mills, Georg Jaeschke
Publikováno v:
Nature neuroscience
Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Here we show using a mouse with the same genetic deficiency that metabotropic
Autor:
Robert Haslinger, Alev Erisir, Marc Nahmani, Jeffrey P. Gavornik, Arnold J. Heynen, Mark F. Bear, Jason E. Coleman
Publikováno v:
Journal of Neuroscience. 30:9670-9682
Monocular lid closure (MC) causes a profound shift in the ocular dominance (OD) of neurons in primary visual cortex (V1). Anatomical studies in both cat and mouse V1 suggest that large-scale structural rearrangements of eye-specific thalamocortical (