Activation of the IL-2 Receptor in Podocytes: A Potential Mechanism for Podocyte Injury in Idiopathic Nephrotic Syndrome?

Autor: Arnold H Zea, Tyrus Stewart, Jeannine Ascani, David J Tate, Beatriz Finkel-Jimenez, Anna Wilk, Krzysztof Reiss, William E Smoyer, Diego H Aviles

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0157907 (2016)

The renal podocyte plays an important role in maintaining the structural integrity of the glomerular basement membrane. We have previously reported that patients with idiopathic nephrotic syndrome (INS) have increased IL-2 production. We hypothesized

Externí odkaz: https://doaj.org/article/5a8cbaa45f744f8d85e57d8f99b6ab36

Post-exposure therapeutic efficacy of COX-2 inhibition against Burkholderia pseudomallei.

Autor: Saja Asakrah, Wildaliz Nieves, Zaid Mahdi, Mallory Agard, Arnold H Zea, Chad J Roy, Lisa A Morici

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 5, p e2212 (2013)

Burkholderia pseudomallei is a Gram-negative, facultative intracellular bacillus and the etiologic agent of melioidosis, a severe disease in Southeast Asia and Northern Australia. Like other multidrug-resistant pathogens, the inherent antibiotic resi

Externí odkaz: https://doaj.org/article/b216055128c349bf991bd8ce5f76f353

Data from Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients

Autor: James H. Finke, Ronald Bukowski, Robert Dreicer, Jorge Garcia, Laura Wood, Patricia A. Rayman, Ali Golshayan, Peter Cohen, Paul Elson, Joanna L. Ireland, Brian I. Rini, Arnold H. Zea, Jennifer S. Ko

Purpose: Immune dysfunction reported in renal cell carcinoma (RCC) patients may contribute to tumor progression. Myeloid-derived suppressor cells (MDSC) represent one mechanism by which tumors induce T-cell suppression. Several factors pivotal to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ebd55e3c66e34c27455c2a8599039f
https://doi.org/10.1158/1078-0432.c.6517944.v1

Data from Arginase-Producing Myeloid Suppressor Cells in Renal Cell Carcinoma Patients: A Mechanism of Tumor Evasion

Autor: Augusto C. Ochoa, James Mier, Anne O'Neill, Amanda Youmans, David Quiceno, David McDermott, Jovanny Zabaleta, Sabina Signoretti, Claudia Hernandez, Michael B. Atkins, Paulo C. Rodriguez, Arnold H. Zea

Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. These cells, described as macrophages or immature dendritic cells, deplete arginine and impair T cell proliferation and cytokine p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb030513d1a7eca18fea30e3a93e8d9
https://doi.org/10.1158/0008-5472.c.6494129

In-depth characterization of a new patient-derived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types

Autor: Augusto C. Ochoa, E F Cromwell, H Brown, Elizabeth C. Martin, O Sirenko, Krzysztof Moroz, Matthew E. Burow, A M Ham, Katherine Hebert, S Sinha, Erik F. Flemington, Jovanny Zabaleta, Hope E. Burks, Jacob Bursavich, Margarite D. Matossian, A I Riker, Steven Elliott, Bridgette M. Collins-Burow, Khoa Nguyen, Maryl K. Wright, Gabrielle O. Windsor, Frank H. Lau, Connor T. King, Henri Wathieu, Reza Izadpanah, Melody Baddoo, Madlin Alzoubi, Arnold H. Zea, Tiffany R. Chang, Lucio Miele, Rachel A. Sabol, Bruce A. Bunnell, J J Savoie

Publikováno v: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Metaplastic breast carcinoma (MBC) is a rare breast cancer subtype with rapid growth, high rates of metastasis, recurrence and drug resistance, and diverse molecular and histological heterogeneity. Patient-derived xenografts (PDXs) provide a translat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7608096d198218e92f3849a83769035
https://doi.org/10.1007/s12094-021-02677-8