A scalable, clinically severe pig model for Duchenne muscular dystrophy.

Autor: Stirm M; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany., Fonteyne LM; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany., Shashikadze B; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany., Lindner M; Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany., Chirivi M; Fondazione Istituto Nazionale di Genetica Molecolare, 20122 Milan, Italy.; Department of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy., Lange A; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany., Kaufhold C; Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany., Mayer C; Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany., Medugorac I; Population Genomics Group, Department of Veterinary Sciences, LMU Munich, 82152 Martinsried, Germany., Kessler B; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany., Kurome M; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany., Zakhartchenko V; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany., Hinrichs A; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany., Kemter E; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany., Krause S; Friedrich Baur Institute, Department of Neurology, LMU Munich, 80336 Munich, Germany., Wanke R; Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany., Arnold GJ; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany., Wess G; Clinic of Small Animal Medicine, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany., Nagashima H; Meiji University International Institute for Bio-Resource Research, 214-8571 Kawasaki, Japan., Hrabĕ de Angelis M; Institute of Experimental Genetics, Helmholtz Zentrum Munich, 85764 Neuherberg, Germany.; Chair of Experimental Genetics, TUM School of Life Sciences, Technische Universität München, 85354 Freising, Germany., Flenkenthaler F; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany., Kobelke LA; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany., Bearzi C; Fondazione Istituto Nazionale di Genetica Molecolare, 20122 Milan, Italy.; Institute of Genetic and Biomedical Research, UOS of Milan, National Research Council (IRGB-CNR), 20122 Milan, Italy., Rizzi R; Fondazione Istituto Nazionale di Genetica Molecolare, 20122 Milan, Italy.; Institute for Biomedical Technologies, National Research Council (ITB-CNR), Segrate, 20090 Milan, Italy., Bähr A; Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University Munich and German Center for Cardiovascular Research (DZHK), Munich Heart Alliance, 81675 Munich, Germany., Reese S; Chair for Anatomy, Histology and Embryology, Department of Veterinary Sciences, LMU Munich, 80539 Munich, Germany., Matiasek K; Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany., Walter MC; Friedrich Baur Institute, Department of Neurology, LMU Munich, 80336 Munich, Germany., Kupatt C; Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University Munich and German Center for Cardiovascular Research (DZHK), Munich Heart Alliance, 81675 Munich, Germany., Ziegler S; Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany., Bartenstein P; Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany., Fröhlich T; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany., Klymiuk N; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany., Blutke A; Institute of Experimental Genetics, Helmholtz Zentrum Munich, 85764 Neuherberg, Germany., Wolf E; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany.; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany.

Publikováno v: Disease models & mechanisms [Dis Model Mech] 2021 Dec 01; Vol. 14 (12). Date of Electronic Publication: 2021 Dec 16.

Long-term exposure of Daphnia magna to polystyrene microplastic (PS-MP) leads to alterations of the proteome, morphology and life-history.

Autor: Trotter B; University of Bayreuth, Animal Ecology 1, Universitätsstraße 30, 95447 Bayreuth, Germany; Gene Center Munich, Laboratory for Functional Genome Analysis (LAFUGA), LMU München, Feodor-Lynen Straße 25, 81377 Munich, Germany., Wilde MV; Gene Center Munich, Laboratory for Functional Genome Analysis (LAFUGA), LMU München, Feodor-Lynen Straße 25, 81377 Munich, Germany. Electronic address: wilde@genzentrum.lmu.de., Brehm J; University of Bayreuth, Animal Ecology 1, Universitätsstraße 30, 95447 Bayreuth, Germany. Electronic address: Julian1.Brehm@uni-bayreuth.de., Dafni E; University of Bayreuth, Animal Ecology 1, Universitätsstraße 30, 95447 Bayreuth, Germany., Aliu A; Gene Center Munich, Laboratory for Functional Genome Analysis (LAFUGA), LMU München, Feodor-Lynen Straße 25, 81377 Munich, Germany. Electronic address: Arlinda.Aliu@campus.lmu.de., Arnold GJ; Gene Center Munich, Laboratory for Functional Genome Analysis (LAFUGA), LMU München, Feodor-Lynen Straße 25, 81377 Munich, Germany. Electronic address: Arnold@genzentrum.lmu.de., Fröhlich T; Gene Center Munich, Laboratory for Functional Genome Analysis (LAFUGA), LMU München, Feodor-Lynen Straße 25, 81377 Munich, Germany. Electronic address: Frohlich@genzentrum.lmu.de., Laforsch C; University of Bayreuth, Animal Ecology 1, Universitätsstraße 30, 95447 Bayreuth, Germany. Electronic address: Christian.Laforsch@uni-bayreuth.de.

Publikováno v: The Science of the total environment [Sci Total Environ] 2021 Nov 15; Vol. 795, pp. 148822. Date of Electronic Publication: 2021 Jul 03.

Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies.

Autor: Hinrichs A; Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany., Riedel EO; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich, Germany., Klymiuk N; Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany., Blutke A; Institute of Experimental Genetics, Helmholtz Zentrum München, Chair of Experimental Genetics, Technical University of Munich, Neuherberg, Germany., Kemter E; Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany., Längin M; Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany., Dahlhoff M; Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany., Keßler B; Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany., Kurome M; Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany., Zakhartchenko V; Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany., Jemiller EM; Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany., Ayares D; Revivicor Inc., Blacksburg, VA, USA., Bidlingmaier M; Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany., Flenkenthaler F; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich, Germany., Hrabĕ de Angelis M; Institute of Experimental Genetics, Helmholtz Zentrum München, Chair of Experimental Genetics, Technical University of Munich, Neuherberg, Germany., Arnold GJ; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich, Germany., Reichart B; Walter Brendel Center for Experimental Medicine, LMU Munich, Munich, Germany., Fröhlich T; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich, Germany., Wolf E; Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany.; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich, Germany.

Publikováno v: Xenotransplantation [Xenotransplantation] 2021 Mar; Vol. 28 (2), pp. e12664. Date of Electronic Publication: 2020 Nov 25.

The impact of transcription inhibition during in vitro maturation on the proteome of bovine oocytes†.

Autor: Gegenfurtner K; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Germany., Flenkenthaler F; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Germany., Fröhlich T; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Germany., Wolf E; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Germany.; Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, Germany., Arnold GJ; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Germany.

Publikováno v: Biology of reproduction [Biol Reprod] 2020 Oct 29; Vol. 103 (5), pp. 1000-1011.

Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma.

Autor: Meßner M; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.; Institute of Pharmacy, Center for Public Health, Paracelsus Medical University, Salzburg, Austria., Schmitt S; School of Medicine, Institute of Toxicology and Environmental Hygiene, Technical University Munich, Munich, Germany., Ardelt MA; Institute of Pharmacy, Center for Public Health, Paracelsus Medical University, Salzburg, Austria., Fröhlich T; Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre, LMU Munich, Munich, Germany., Müller M; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany., Pein H; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Jena, Germany., Huber-Cantonati P; Institute of Pharmacy, Center for Public Health, Paracelsus Medical University, Salzburg, Austria., Ortler C; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany., Koenig LM; Center of Integrated Protein Science Munich (CIPS-M), Division of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany., Zobel L; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany., Koeberle A; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Jena, Germany.; Michael Popp Research Institute, University of Innsbruck, Innsbruck, Austria., Arnold GJ; Laboratory for Functional Genome Analysis (LAFUGA), Gene Centre, LMU Munich, Munich, Germany., Rothenfußer S; Center of Integrated Protein Science Munich (CIPS-M), Division of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany., Kiemer AK; Department of Pharmacy, Pharmaceutical Biology, Saarland University, Saarbrücken, Germany., Gerbes AL; Department of Medicine 2, Liver Center Munich, University Hospital, LMU Munich, Munich, Germany., Zischka H; School of Medicine, Institute of Toxicology and Environmental Hygiene, Technical University Munich, Munich, Germany.; Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Neuherberg, Germany., Vollmar AM; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany., Pachmayr J; Institute of Pharmacy, Center for Public Health, Paracelsus Medical University, Salzburg, Austria.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Sep; Vol. 34 (9), pp. 11860-11882. Date of Electronic Publication: 2020 Jul 11.