Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Arnold E. Ruoho"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3103 (2023)
Both bioactive sphingolipids and Sigma-1 receptor (S1R) chaperones occur ubiquitously in mammalian cell membranes. Endogenous compounds that regulate the S1R are important for controlling S1R responses to cellular stress. Herein, we interrogated the
Externí odkaz:
https://doaj.org/article/30a857f105564799a796e57ae25b4dbe
Autor:
Uyen B. Chu, Timur A. Mavlyutov, Ming-Liang Chu, Huan Yang, Amanda Schulman, Christophe Mesangeau, Christopher R. McCurdy, Lian-Wang Guo, Arnold E. Ruoho
Publikováno v:
EBioMedicine, Vol 2, Iss 11, Pp 1806-1813 (2015)
The sigma-2 receptor (S2R) is a potential therapeutic target for cancer and neuronal diseases. However, the identity of the S2R has remained a matter of debate. Historically, the S2R has been defined as (1) a binding site with high affinity to 1,3-di
Externí odkaz:
https://doaj.org/article/a59889769470463ca1fb2549fc5cc67d
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 1, Pp 10-16 (2015)
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease affecting spinal cord motoneurons (MN) with an associative connection to Frontotemporal Lobar Dementia (FTLD). The endoplasmic reticulum (ER) bound Sigma-1 Receptor (S1R) chaperone pr
Externí odkaz:
https://doaj.org/article/56edaf4cccef47c59584994d9a9342ed
Autor:
Lauren Andrews, Jarrett Rosenberg, Bin Shen, Deepak Behera, Arnold E. Ruoho, Peter Cipriano, Frederick T. Chin, Christopher R. McCurdy, Sanjiv S. Gambhir, Sandip Biswal, Samantha T. Reyes, Michelle L. James, Timur A. Mavlyutov, David C. Yeomans, Amanda Brosius Lutz, Michael Klukinov
Publikováno v:
Theranostics
The ability to locate nerve injury and ensuing neuroinflammation would have tremendous clinical value for improving both the diagnosis and subsequent management of patients suffering from pain, weakness, and other neurologic phenomena associated with
Development of sigma-1 (σ 1 ) receptor fluorescent ligands as versatile tools to study σ 1 receptors
Autor:
Dario Ghigo, Arnold E. Ruoho, Chiara Riganti, Francesco Berardi, Lian-Wang Guo, Carmen Abate, Timur A. Mavlyutov, Maria Laura Pati
Publikováno v:
European Journal of Medicinal Chemistry. 108:577-585
Despite their controversial physiology, sigma-1 (σ1) receptors are intriguing targets for the development of therapeutic agents for central nervous system diseases. With the aim of providing versatile pharmacological tools to study σ1 receptors, we
Autor:
Arnold E. Ruoho, Uyen B. Chu
Publikováno v:
Molecular Pharmacology. 89:142-153
The sigma-1 receptor (S1R) is a 223 amino acid two transmembrane (TM) pass protein. It is a non-ATP-binding nonglycosylated ligand-regulated molecular chaperone of unknown three-dimensional structure. The S1R is resident to eukaryotic mitochondrial-a
Autor:
Ming-Liang Chu, Lian-Wang Guo, Huan Yang, Christopher R. McCurdy, Arnold E. Ruoho, Uyen B. Chu, Amanda Schulman, Christophe Mesangeau, Timur A. Mavlyutov
Publikováno v:
EBioMedicine, Vol 2, Iss 11, Pp 1806-1813 (2015)
EBioMedicine
EBioMedicine
The sigma-2 receptor (S2R) is a potential therapeutic target for cancer and neuronal diseases. However, the identity of the S2R has remained a matter of debate. Historically, the S2R has been defined as (1) a binding site with high affinity to 1,3-di
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0219664 (2019)
PLoS ONE, Vol 14, Iss 7, p e0219664 (2019)
Phenylalanine and cysteine comprise common miss-sense variants (i.e., single nucleotide polymorphisms [SNPs]) at amino acid position 254 of the human indole(ethyl)amine-N-methyltransferase (hINMT). The phenylalanine variant, which occurs in linkage d
Autor:
Ashish K. Mishra, Julie A. Oliver, Gabriel Biener, Deo R. Singh, Jay Yang, Arnold E. Ruoho, Timur A. Mavlyutov, Valerica Raicu
Publikováno v:
Biochemical Journal. 466:263-271
The sigma-1 receptor (S1R) is a 223-amino-acid membrane protein that resides in the endoplasmic reticulum and the plasma membrane of some mammalian cells. The S1R is regulated by various synthetic molecules including (+)-pentazocine, cocaine and halo
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 1, Pp 10-16 (2015)
Journal of pharmacological sciences
Journal of pharmacological sciences
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease affecting spinal cord motoneurons (MN) with an associative connection to Frontotemporal Lobar Dementia (FTLD). The endoplasmic reticulum (ER) bound Sigma-1 Receptor (S1R) chaperone pr