Výsledky vyhledávání - "Arnold E. Postlethwaite"

Akademický článek

20S-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis

Autor: Arnold E. Postlethwaite, Robert C. Tuckey, Tae-Kang Kim, Wei Li, Syamal K. Bhattacharya, Linda K. Myers, David D. Brand, Andrzej T. Slominski

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The ability to use large doses of vitamin D3 (D3) to chronically treat autoimmune diseases such as rheumatoid arthritis (RA) is prohibitive due to its calcemic effect which can damage vital organs. Cytochrome P450scc (CYP11A1) is able to convert D3 i

Externí odkaz: https://doaj.org/article/fa1661234a1b494fb2fa119c0157414a

Zobrazit plný text záznamu

Akademický článek

Retrospective Analysis of the Impact of Adalimumab Initiation on Corticosteroid Utilization and Medical Costs Among Biologic-Naïve Patients with Rheumatoid Arthritis

Autor: Christina A. Spivey, Kevin L. Winthrop, Jenny Griffith, Cameron M. Kaplan, Yanru Qiao, Arnold E. Postlethwaite, Junling Wang

Publikováno v: Rheumatology and Therapy, Vol 7, Iss 1, Pp 133-147 (2019)

Abstract Introduction Treatment guidelines recommend low-dose corticosteroids as short-term therapy among rheumatoid arthritis (RA) patients. However, it may be difficult to wean/eliminate steroids once initiated. Initiation of more effective therapi

Externí odkaz: https://doaj.org/article/a2c978f04fce4818b21108fa694e83e1

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Sex Differences in Correlation with Gene Expression Levels between Ifi200 Family Genes and Four Sets of Immune Disease-Relevant Genes

Autor: Yanhong Cao, Lishi Wang, Cong-Yi Wang, Jicheng Ye, Ying Wang, Tiantian Li, Franklin Garcia-Godoy, Dianjun Sun, Weikuan Gu, Arnold E. Postlethwaite

Publikováno v: Journal of Immunology Research, Vol 2018 (2018)

Background. The HIN-200 family genes in humans have been linked to several autoimmune diseases—particularly to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Recently, its human counterpart gene cluster, the Ifi200 family in mice

Externí odkaz: https://doaj.org/article/baf44631c62949898ff6e01e3620bf5d

Zobrazit plný text záznamu

Plný text ve formátu HTML

COVID-19 vaccine: Call for employees in international transportation industries and international travelers as the first priority in global distribution

Autor: Zhuo Yu, Weikuan Gu, Dianjun Sun, Marcello Maida, Gang Wang, Arnold E. Postlethwaite, Barbara Zangerl, Sara W. Day, Lotfi Aleya, Yanhong Cao, Ning Xie, Jiafu Ji, Kunal Ray, Emanuel Goldman, Jingyu Chen, Monica M. Jablonski, Scott C. Howard

Publikováno v: Open Medicine, Vol 16, Iss 1, Pp 134-138 (2021)
Open Medicine
Open Medicine, De Gruyter, 2021, 16, pp.134-138. ⟨10.1515/med-2021-0210⟩

While countries are in a hurry to obtain SARS-CoV-2 vaccine, we are concerned with the availability of vaccine and whether a vaccine will be available to all in need. We predicted three possible scenarios for vaccine distributions and urge an interna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2ea8ae5fa981052f5036bb51e0f794
https://doaj.org/article/c7c8c0b652294368b6313e8b16c002fb

Zobrazit plný text záznamu

Extra-adrenal glucocorticoid biosynthesis: Implications for autoimmune and inflammatory disorders

Autor: Arnold E. Postlethwaite, Pulak R. Manna, Chander Raman, Anton M. Jetten, Radomir M. Slominski, Andrzej Slominski, Robert C. Tuckey

Publikováno v: Genes and immunity

Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here its side chain is cleaved by CYP11A1 producing pregnenolone. Pregnenol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c0e644cb4347769c2308a76e56fba4
http://europepmc.org/articles/PMC7276297

Zobrazit plný text záznamu

Modulation by 17,20S(OH)2pD of Fibrosis-Related Mediators in Dermal Fibroblast Lines from Healthy Donors and from Patients with Systemic Sclerosis

Autor: Monica L. Brown Lobbins, Andrzej T. Slominski, Karen A. Hasty, Sicheng Zhang, Duane D. Miller, Wei Li, Tae-Kang Kim, Zorica Janjetovic, Robert C. Tuckey, Imara-Safi O. Scott, Linda K. Myers, Arnold E. Postlethwaite

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 367
International Journal of Molecular Sciences, Vol 23, Iss 367, p 367 (2022)

We previously demonstrated that the non-calcemic pregnacalciferol (pD) analog 17,20S (OH)2pD suppressed TGF-β1-induced type I collagen production in cultured normal human dermal fibroblasts. In the present studies, we examined fibroblasts cultured f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99fd26eeed67619f8059beae8322da53

Zobrazit plný text záznamu

Plný text ve formátu HTML

Modulation by 17,20S(OH)

Autor: Monica L, Brown Lobbins, Andrzej T, Slominski, Karen A, Hasty, Sicheng, Zhang, Duane D, Miller, Wei, Li, Tae-Kang, Kim, Zorica, Janjetovic, Robert C, Tuckey, Imara-Safi O, Scott, Linda K, Myers, Arnold E, Postlethwaite

Publikováno v: International Journal of Molecular Sciences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1491bf5d72de23e2d33b45683c75b2d4
https://pubmed.ncbi.nlm.nih.gov/35008794

Zobrazit plný text záznamu

17,20S(OH)2pD Can Prevent the Development of Skin Fibrosis in the Bleomycin-Induced Scleroderma Mouse Model

Autor: Andrzej Slominski, Imara-Safi O Scott, Duane D. Miller, Zorica Janjetovic, Wei Li, Arnold E. Postlethwaite, Linda K. Myers, Sicheng Zhang, Tejesh Patel, Monica L Brown Lobbins, Karen A. Hasty, Tae Kang Kim

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8926, p 8926 (2021)

Systemic sclerosis (SSc
scleroderma) is a chronic fibrotic disease involving TGF-β1. Low serum vitamin D (vit D) correlates with the degree of fibrosis and expression of TGF-β1. This study was designed to determine whether the noncalcemic vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec68cb7abb4254d43c2a48195bae9741

Zobrazit plný text záznamu

Retrospective Analysis of the Impact of Adalimumab Initiation on Corticosteroid Utilization and Medical Costs Among Biologic-Naïve Patients with Rheumatoid Arthritis

Autor: Arnold E. Postlethwaite, Junling Wang, Christina A. Spivey, Kevin L. Winthrop, Yanru Qiao, Jenny Griffith, Cameron M. Kaplan

Publikováno v: Rheumatology and Therapy, Vol 7, Iss 1, Pp 133-147 (2019)
Rheumatology and Therapy

Introduction Treatment guidelines recommend low-dose corticosteroids as short-term therapy among rheumatoid arthritis (RA) patients. However, it may be difficult to wean/eliminate steroids once initiated. Initiation of more effective therapies such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3884bf62b4d0944ab90d19b248679e16
http://link.springer.com/article/10.1007/s40744-019-00184-5

Zobrazit plný text záznamu

Capacity of transportation and spread of COVID-19-an ironical fact for developed countries

Autor: Arnold E. Postlethwaite, Heliang Yin, Wei Zhong, Yan Jiao, Qiang Li, Hong Chen, Gang Wang, Zhuo Yu, Lin Lin, Sara W. Day, Li Ma

Publikováno v: Environmental Science and Pollution Research International

The widespread epidemic of the COVID-19 in developed countries such as Europe and the USA has sparked many speculations. What factors caused the rapid early pandemic of the COVID-19 in developed countries is the main goal of this study. We collected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261c0bf8724df328630b258e03ceef59
https://pubmed.ncbi.nlm.nih.gov/33713261

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání