Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Arnold E Postlethwaite"'
Autor:
Tae Won Yoon, Young-In Kim, Hongsik Cho, David D Brand, Edward F Rosloniec, Linda K Myers, Arnold E Postlethwaite, Karen A Hasty, John M Stuart, Ae-Kyung Yi
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226145 (2019)
Toll-like receptor (TLR) signaling can contribute to the pathogenesis of arthritis. Disruption of TLR signaling at early stages of arthritis might thereby provide an opportunity to halt the disease progression and ameliorate outcomes. We previously f
Externí odkaz:
https://doaj.org/article/74b836178f914fb59706a2455015e84f
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
SSc is one of the most complex systemic autoimmune diseases. It targets the vasculature, connective tissue producing cells (namely fibroblasts/myofibroblasts), and components of the innate and adaptive immune systems. Clinical and pathologic manifest
Externí odkaz:
https://doaj.org/article/d84faf8f7fe4413aafca4d0970ec9a8a
Autor:
Lishi Wang, Hongchao Liu, Yan Jiao, Erjian Wang, Stephen H. Clark, Arnold E. Postlethwaite, Weikuan Gu, Hong Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 7, Pp 15031-15056 (2015)
Collagen, type III, alpha-1 (COL3A1) is essential for normal collagen I fibrillogenesis in many organs. There are differences in phenotypes of mutations in the COL3A1 gene in humans and mutations in mice. In order to investigate whether the regulatio
Externí odkaz:
https://doaj.org/article/2b322ba26b9e4c0487432d2e9f6aa4a5
Autor:
Zhuo Yu, Weikuan Gu, Dianjun Sun, Marcello Maida, Gang Wang, Arnold E. Postlethwaite, Barbara Zangerl, Sara W. Day, Lotfi Aleya, Yanhong Cao, Ning Xie, Jiafu Ji, Kunal Ray, Emanuel Goldman, Jingyu Chen, Monica M. Jablonski, Scott C. Howard
Publikováno v:
Open Medicine, Vol 16, Iss 1, Pp 134-138 (2021)
Open Medicine
Open Medicine, De Gruyter, 2021, 16, pp.134-138. ⟨10.1515/med-2021-0210⟩
Open Medicine
Open Medicine, De Gruyter, 2021, 16, pp.134-138. ⟨10.1515/med-2021-0210⟩
While countries are in a hurry to obtain SARS-CoV-2 vaccine, we are concerned with the availability of vaccine and whether a vaccine will be available to all in need. We predicted three possible scenarios for vaccine distributions and urge an interna
Autor:
Arnold E. Postlethwaite, Pulak R. Manna, Chander Raman, Anton M. Jetten, Radomir M. Slominski, Andrzej Slominski, Robert C. Tuckey
Publikováno v:
Genes and immunity
Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here its side chain is cleaved by CYP11A1 producing pregnenolone. Pregnenol
Autor:
Arnold E. Postlethwaite, Junling Wang, Christina A. Spivey, Kevin L. Winthrop, Yanru Qiao, Jenny Griffith, Cameron M. Kaplan
Publikováno v:
Rheumatology and Therapy, Vol 7, Iss 1, Pp 133-147 (2019)
Rheumatology and Therapy
Rheumatology and Therapy
Introduction Treatment guidelines recommend low-dose corticosteroids as short-term therapy among rheumatoid arthritis (RA) patients. However, it may be difficult to wean/eliminate steroids once initiated. Initiation of more effective therapies such a
Autor:
Monica L. Brown Lobbins, Andrzej T. Slominski, Karen A. Hasty, Sicheng Zhang, Duane D. Miller, Wei Li, Tae-Kang Kim, Zorica Janjetovic, Robert C. Tuckey, Imara-Safi O. Scott, Linda K. Myers, Arnold E. Postlethwaite
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 367
International Journal of Molecular Sciences, Vol 23, Iss 367, p 367 (2022)
International Journal of Molecular Sciences, Vol 23, Iss 367, p 367 (2022)
We previously demonstrated that the non-calcemic pregnacalciferol (pD) analog 17,20S (OH)2pD suppressed TGF-β1-induced type I collagen production in cultured normal human dermal fibroblasts. In the present studies, we examined fibroblasts cultured f
Autor:
Monica L, Brown Lobbins, Andrzej T, Slominski, Karen A, Hasty, Sicheng, Zhang, Duane D, Miller, Wei, Li, Tae-Kang, Kim, Zorica, Janjetovic, Robert C, Tuckey, Imara-Safi O, Scott, Linda K, Myers, Arnold E, Postlethwaite
Publikováno v:
International Journal of Molecular Sciences
We previously demonstrated that the non-calcemic pregnacalciferol (pD) analog 17,20S (OH)2pD suppressed TGF-β1-induced type I collagen production in cultured normal human dermal fibroblasts. In the present studies, we examined fibroblasts cultured f
Autor:
Andrzej Slominski, Imara-Safi O Scott, Duane D. Miller, Zorica Janjetovic, Wei Li, Arnold E. Postlethwaite, Linda K. Myers, Sicheng Zhang, Tejesh Patel, Monica L Brown Lobbins, Karen A. Hasty, Tae Kang Kim
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8926, p 8926 (2021)
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8926, p 8926 (2021)
Systemic sclerosis (SSc
scleroderma) is a chronic fibrotic disease involving TGF-β1. Low serum vitamin D (vit D) correlates with the degree of fibrosis and expression of TGF-β1. This study was designed to determine whether the noncalcemic vit
scleroderma) is a chronic fibrotic disease involving TGF-β1. Low serum vitamin D (vit D) correlates with the degree of fibrosis and expression of TGF-β1. This study was designed to determine whether the noncalcemic vit
Autor:
Arnold E. Postlethwaite, Robert C. Tuckey, Tae-Kang Kim, Wei Li, Syamal K. Bhattacharya, Linda K. Myers, David D. Brand, Andrzej T. Slominski
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
The ability to use large doses of vitamin D3 (D3) to chronically treat autoimmune diseases such as rheumatoid arthritis (RA) is prohibitive due to its calcemic effect which can damage vital organs. Cytochrome P450scc (CYP11A1) is able to convert D3 i