Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Arnold D. K. Hill"'
Autor:
Gavin P. Dowling, Sinead Toomey, Philip Bredin, Imelda Parker, Eibhlin Mulroe, Jacinta Marron, Olivia McLoughlin, Ausra Teiserskiene, Colm Power, Anne Marie O’Shea, Megan Greally, Patrick G. Morris, Deirdre Duke, Arnold D. K. Hill, Bryan T. Hennessy
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background The current standard of care in the neoadjuvant setting for high-risk HER2-positive (HER2 +) breast cancer is to combine systemic chemotherapy with dual HER2 blockade, trastuzumab and pertuzumab. Targeted therapies have significan
Externí odkaz:
https://doaj.org/article/525da2fab1674ea289c10763a6526868
Autor:
Sherlissa Ali-Thompson, Gordon R. Daly, Gavin P. Dowling, Conor Kilkenny, Luke Cox, Jason McGrath, Ma’en M. AlRawashdeh, Sindhuja Naidoo, Colm Power, Arnold D. K. Hill
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
AimThe overamplification of human epidermal growth factor (HER2) in breast cancer (BC) has been the subject of numerous research publications since its discovery in 1987. This is the first bibliometric analysis (BA) conducted on HER2-positive (HER2+)
Externí odkaz:
https://doaj.org/article/f147a5ddea4d468ab15878bf994f1c02
Autor:
Gavin P. Dowling, Stephen Keelan, Sinead Toomey, Gordon R. Daly, Bryan T. Hennessy, Arnold D. K. Hill
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
PurposeThe development of human epidermal growth factor receptor 2 (HER2)-directed therapies has revolutionized the treatment of HER2-positive breast cancer. The aim of this article is to review the continually evolving treatment strategies in the ne
Externí odkaz:
https://doaj.org/article/6a03b95135c141528bd2fbe1e3202046
Autor:
Nicola Cosgrove, Damir Varešlija, Stephen Keelan, Ashuvinee Elangovan, Jennifer M. Atkinson, Sinéad Cocchiglia, Fiona T. Bane, Vikrant Singh, Simon Furney, Chunling Hu, Jodi M. Carter, Steven N. Hart, Siddhartha Yadav, Matthew P. Goetz, Arnold D. K. Hill, Steffi Oesterreich, Adrian V. Lee, Fergus J. Couch, Leonie S. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The molecular landscape of breast cancer brain metastases (BCBM) is still understudied, especially for different breast cancer subtypes. Here, the authors characterise subtype-specific BCBMs using genomics and transcriptomics and identify homologous
Externí odkaz:
https://doaj.org/article/55e3acfd61844f0f8a60e2f4411af4cc
Autor:
Sara Charmsaz, Ben Doherty, Sinéad Cocchiglia, Damir Varešlija, Attilio Marino, Nicola Cosgrove, Ricardo Marques, Nolan Priedigkeit, Siobhan Purcell, Fiona Bane, Jarlath Bolger, Christopher Byrne, Philip J. O’Halloran, Francesca Brett, Katherine Sheehan, Kieran Brennan, Ann M. Hopkins, Stephen Keelan, Petra Jagust, Stephen Madden, Chiara Martinelli, Matteo Battaglini, Steffi Oesterreich, Adrian V. Lee, Gianni Ciofani, Arnold D. K. Hill, Leonie S. Young
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Metastatic breast cancer is a major cause of cancer-related deaths in woman. Brain metastasis is a common and devastating site of relapse for several breast cancer molecular subtypes, including oestrogen receptor-positive disease,
Externí odkaz:
https://doaj.org/article/1f3f5704f584477bb63287d1160a16a1
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The management of breast cancer has evolved into a multidisciplinary evidence-based surgical speciality, with emphasis on conservative surgery. A number of landmark trials have established lumpectomy followed by radiation as the standard of care for
Externí odkaz:
https://doaj.org/article/767f89bc8da74ada96c6599f6aa7b5b5
Autor:
Astrid O. Leech, Sri HariKrishna Vellanki, Emily J. Rutherford, Aoife Keogh, Hanne Jahns, Lance Hudson, Norma O’Donovan, Siham Sabri, Bassam Abdulkarim, Katherine M. Sheehan, Elaine W. Kay, Leonie S. Young, Arnold D. K. Hill, Yvonne E. Smith, Ann M. Hopkins
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-18 (2018)
Abstract Background Junctional adhesion molecule-A (JAM-A) is an adhesion molecule whose overexpression on breast tumor tissue has been associated with aggressive cancer phenotypes, including human epidermal growth factor receptor-2 (HER2)-positive d
Externí odkaz:
https://doaj.org/article/72a1a9c60a1942e4bc9a56db7d21098a
Autor:
Yvonne E. Smith, Guannan Wang, Ciara L. Flynn, Stephen F. Madden, Owen MacEneaney, Rodrigo G. B. Cruz, Cathy E. Richards, Hanne Jahns, Marian Brennan, Mattia Cremona, Bryan T. Hennessy, Katherine Sheehan, Alexander Casucci, Faizah A. Sani, Lance Hudson, Joanna Fay, Sri H. Vellanki, Siobhan O’Flaherty, Marc Devocelle, Arnold D. K. Hill, Kieran Brennan, Saraswati Sukumar, Ann M. Hopkins
Publikováno v:
Cancers, Vol 14, Iss 5, p 1303 (2022)
Breast ductal carcinoma in situ (DCIS) is clinically challenging, featuring high diagnosis rates and few targeted therapies. Expression/signaling from junctional adhesion molecule-A (JAM-A) has been linked to poor prognosis in invasive breast cancers
Externí odkaz:
https://doaj.org/article/980dcc0220c545358fc67598ba939e8a
Autor:
Cathy E. Richards, Katherine M. Sheehan, Elaine W. Kay, Charlotta Hedner, David Borg, Joanna Fay, Anthony O’Grady, Arnold D. K. Hill, Karin Jirström, Ann M. Hopkins
Publikováno v:
Cancers, Vol 13, Iss 6, p 1286 (2021)
High expression of Junctional Adhesion Molecule-A (JAM-A) has been linked with poor prognosis in several cancers, including breast cancers overexpressing the human epidermal growth factor receptor-2 (HER2). Furthermore, JAM-A expression has been link
Externí odkaz:
https://doaj.org/article/8d281131c3534be4a0435ee20ad6c911
Assessing Clinical Acumen in Predicting Acute Appendicitis in Emergency Surgery: A Prospective Study
Autor:
Angus J. Lloyd, Michael R. Boland, Eoin Cleere, Frances Fallon, James Toale, Arnold D. K. Hill
Publikováno v:
World Journal of Surgery. 47:922-927