Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Arno de Wilde"'
Autor:
Marlies Oosthoek, Lisa Vermunt, Arno de Wilde, Bram Bongers, Daniel Antwi-Berko, Philip Scheltens, Pieter van Bokhoven, Everard G. B. Vijverberg, Charlotte E. Teunissen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Clinical trials in Alzheimer’s disease (AD) had high failure rates for several reasons, including the lack of biological endpoints. Fluid-based biomarkers may present a solution to measure biologically relevant endpoints. It is
Externí odkaz:
https://doaj.org/article/ae49560852f74a098698937680d6a2cf
Autor:
Pieter van Bokhoven, Arno de Wilde, Lisa Vermunt, Prisca S. Leferink, Sasja Heetveld, Jeffrey Cummings, Philip Scheltens, Everard G. B. Vijverberg
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-9 (2021)
Abstract Background Alzheimer’s disease (AD) is a devastating neurodegenerative disease leading to dementia. The field has made significant progress over the last 15 years. AD diagnosis has shifted from syndromal, based on signs and symptoms, to a
Externí odkaz:
https://doaj.org/article/75d2847abf9c4438ab9936c7a8f4ae9a
Autor:
Inge M. W. Verberk, Elisabeth Thijssen, Jannet Koelewijn, Kimberley Mauroo, Jeroen Vanbrabant, Arno de Wilde, Marissa D. Zwan, Sander C. J. Verfaillie, Rik Ossenkoppele, Frederik Barkhof, Bart N. M. van Berckel, Philip Scheltens, Wiesje M. van der Flier, Erik Stoops, Hugo M. Vanderstichele, Charlotte E. Teunissen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2020)
Abstract Background Blood-based biomarkers for Alzheimer’s disease (AD) might facilitate identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation, and aid in AD diagnostics. We examined the potential of plasma
Externí odkaz:
https://doaj.org/article/9594bf99360a4fe291a094b11e902095
Autor:
Juhan Reimand, Arno de Wilde, Charlotte E. Teunissen, Marissa Zwan, Albert D. Windhorst, Ronald Boellaard, Frederik Barkhof, Wiesje M. van der Flier, Philip Scheltens, Bart N. M. van Berckel, Rik Ossenkoppele, Femke Bouwman
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-16 (2019)
Abstract Background Amyloid-β PET and CSF Aβ42 yield discordant results in 10–20% of memory clinic patients, possibly providing unique information. Although the predictive power of demographic, clinical, genetic, and imaging features for amyloid
Externí odkaz:
https://doaj.org/article/38e9cf71018d42679c12dceee4186115
Autor:
Arno de Wilde, Juhan Reimand, Charlotte E. Teunissen, Marissa Zwan, Albert D. Windhorst, Ronald Boellaard, Wiesje M. van der Flier, Philip Scheltens, Bart N. M. van Berckel, Femke Bouwman, Rik Ossenkoppele
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2019)
Abstract Background In vivo, high cerebral amyloid-β load has been associated with (i) reduced concentrations of Aβ42 in cerebrospinal fluid and (ii) increased retention using amyloid-β positron emission tomography. Although these two amyloid-β b
Externí odkaz:
https://doaj.org/article/6d9d2c41c5a7421e8e623af43f06aa5e
Autor:
James E. Galvin, Paul Aisen, Jessica B. Langbaum, Eric Rodriguez, Marwan Sabbagh, Richard Stefanacci, Robert A. Stern, Elizabeth A. Vassey, Arno de Wilde, Neva West, Ivana Rubino
Publikováno v:
Frontiers in Neurology, Vol 11 (2021)
Alzheimer's disease (AD) is a progressive, neurodegenerative disease that creates complex challenges and a significant burden for patients and caregivers. Although underlying pathological changes due to AD may be detected in research studies decades
Externí odkaz:
https://doaj.org/article/08b446c7652441e4add7c8865f31891b
Autor:
Arno de Wilde, Marieke M. van Buchem, René H. J. Otten, Femke Bouwman, Andrew Stephens, Frederik Barkhof, Philip Scheltens, Wiesje M. van der Flier
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-12 (2018)
Abstract Background Disclosure of amyloid positron emission tomography (PET) results to individuals without dementia has become standard practice in secondary prevention trials and also increasingly occurs in clinical practice. However, this is contr
Externí odkaz:
https://doaj.org/article/7b1e4e5060e34ece8c170bf1814d8df1
Autor:
Malcolm R Macleod, Aaron Lawson McLean, Aikaterini Kyriakopoulou, Stylianos Serghiou, Arno de Wilde, Nicki Sherratt, Theo Hirst, Rachel Hemblade, Zsanett Bahor, Cristina Nunes-Fonseca, Aparna Potluru, Andrew Thomson, Julija Baginskaite, Kieren Egan, Hanna Vesterinen, Gillian L Currie, Leonid Churilov, David W Howells, Emily S Sena
Publikováno v:
PLoS Biology, Vol 13, Iss 11, p e1002301 (2015)
[This corrects the article DOI: 10.1371/journal.pbio.1002273.].
Externí odkaz:
https://doaj.org/article/2d2c0cbe4ef247dcb0f6ba210b3ad35d
Autor:
Malcolm R Macleod, Aaron Lawson McLean, Aikaterini Kyriakopoulou, Stylianos Serghiou, Arno de Wilde, Nicki Sherratt, Theo Hirst, Rachel Hemblade, Zsanett Bahor, Cristina Nunes-Fonseca, Aparna Potluru, Andrew Thomson, Julija Baginskaite, Kieren Egan, Hanna Vesterinen, Gillian L Currie, Leonid Churilov, David W Howells, Emily S Sena
Publikováno v:
PLoS Biology, Vol 13, Iss 10, p e1002273 (2015)
The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisat
Externí odkaz:
https://doaj.org/article/64bd37c7387b4e56912c0232e308d135
Autor:
Lyduine E, Collij, Gemma, Salvadó, Arno, de Wilde, Daniele, Altomare, Mahnaz, Shekari, Juan Domingo, Gispert, Santiago, Bullich, Andrew, Stephens, Frederik, Barkhof, Philip, Scheltens, Femke, Bouwman, Wiesje M, van der Flier
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES.
We investigated amyloid-burden quantification in a mixed memory clinic population.[CL was associated with syndromic (F = 4.42, p = 0.014) and etiological diagnosis (F = -12.66, p 0.001), with Alzheimer's disease (AD) patients showing the highest amyl