Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Arno Paessens"'
Autor:
Y. Hsiou, Reinhard Kirsch, Irvin Winkler, Gunther Riess, Manfred Rösner, Edward Arnold, Arno Paessens, Jorg-Peter Kleim
Publikováno v:
Proceedings of the National Academy of Sciences. 93:34-38
The quinoxaline nonnucleoside RT inhibitor (NNRTI) (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4- dihydroquinoxaline-2(1H)-thione (HBY 097) was used to select for drug-resistant HIV-1 variants in vitro. The viruses first developed mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd7089bd332ff10f9b78508a768626d
https://doi.org/10.1073/pnas.93.1.34
https://doi.org/10.1073/pnas.93.1.34
Autor:
Anusch Peyman, Karl-Heinz Budt, Jutta Dr Hansen, Ruppert Dieter, Arno Paessens, Christoph Dr. Meichsner, Bernd Stowasser, Jochen Knolle
Publikováno v:
Bioorganic & Medicinal Chemistry. 3:559-571
A detailed structure-activity relationship of C 2 -symmetric diol inhibitors of HIV-1 protease leads to inhibitor 6 (HOE/BAY 793) which is outstanding in the inhibition of the enzyme and in the inhibition of viral replication in HIV infected cell cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63be7354aed17c968a5fc362384a529c
https://doi.org/10.1016/0968-0896(95)00069-s
https://doi.org/10.1016/0968-0896(95)00069-s
Autor:
Christoph Dr. Meichsner, Konrad Wagner, Karl-Heinz Budt, Ruppert Dieter, Arno Paessens, Jörg Spanig, Anusch Peyman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1191-1194
The inhibition of HIV protease with C2-symmetric phosphinic acid based inhibitors is independent of the dissociation grade of the phosphinic acid. The corresponding amides are not only good inhibitors of HIV protease but also inhibit HIV replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b6dd5e8278e26eeaea0408d834c7fd9
https://doi.org/10.1016/s0960-894x(01)80327-9
https://doi.org/10.1016/s0960-894x(01)80327-9
Autor:
Jörg-Peter Kleim, Arno Paessens, Manfred Rösner, Gunther Riess, Reinhard Kirsch, Helga Rübsamen-Waigmann, Irvin Winkler
Publikováno v:
Virology. 231(1)
In vitro resistance of HIV-1 against high levels of HBY 097 (( S )-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-dihydro-quinoxaline-2(1 H )-thione) and other quinoxaline nonnucleoside reverse transcriptase inhibitors (NNRTIs) is characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a42e42e0416c740d0c4123e60002594
https://pubmed.ncbi.nlm.nih.gov/9143309
https://pubmed.ncbi.nlm.nih.gov/9143309
Publikováno v:
Virology. 200(2)
S-2720 and other members of the quinoline/quinoxaline class of HIV-1-specific nonnucleoside reverse transcriptase inhibitors (NNRTIs) select for a glycine to glutamate substitution at residue 190 (Gly 190 Glu) of the reverse transcriptase (RT), when
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f171af7ea8bf68ead139a5056e5c5e46
https://pubmed.ncbi.nlm.nih.gov/7513921
https://pubmed.ncbi.nlm.nih.gov/7513921
Autor:
Anita Shah, Jörg-Peter Kleim, Arno Paessens, Edward Huguenel, Helga Rübsamen-Waigmann, Mark A. Wainberg
Publikováno v:
The Lancet. 349:1517
to –1·38 log10) (table). In one of five patients who received 250 mg and two of five patients on 750 mg, viral load went below detection. In the high-dose cohorts, the mean viral load stayed below the value at entry after a 7-day washout period (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4333e785a8feb36459c5f50aa82c44e
https://doi.org/10.1016/s0140-6736(97)24021-3
https://doi.org/10.1016/s0140-6736(97)24021-3