Výsledky vyhledávání - "Arno Mullbacher"

Akademický článek

MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies.

Autor: Mohammed Alsharifi, Aulikki Koskinen, Danushka K Wijesundara, Jayaram Bettadapura, Arno Müllbacher

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e68458 (2013)

MHCII molecules are heterodimeric cell surface proteins composed of an α and β chain. These molecules are almost exclusively expressed on thymic epithelium and antigen presenting cells (APCs) and play a central role in the development and function

Externí odkaz: https://doaj.org/article/b06e3769da394153adb769bceaa0f62f

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Akademický článek

In vivo elimination of MHC-I-deficient lymphocytes by activated natural killer cells is independent of granzymes A and B.

Autor: Matthias Regner, Lisa Pavlinovic, Nicolie Young, Arno Müllbacher

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23252 (2011)

NK cells kill target cells mainly via exocytosis of granules containing perforin (perf) and granzymes (gzm). In vitro, gzm delivery into the target cell cytosol results in apoptosis, and induction of apoptosis is severely impaired in the absence of g

Externí odkaz: https://doaj.org/article/c3361fd38f2b47f5b9389d6227a5ec61

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Akademický článek

Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway.

Autor: Yoichi Furuya, Jennifer Chan, En-Chi Wan, Aulikki Koskinen, Kerrilyn R Diener, John D Hayball, Matthias Regner, Arno Müllbacher, Mohammed Alsharifi

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25765 (2011)

BACKGROUND: We have shown previously in mice, that infection with live viruses, including influenza/A and Semliki Forest virus (SFV), induces systemic partial activation of lymphocytes, characterized by cell surface expression of CD69 and CD86, but n

Externí odkaz: https://doaj.org/article/ad2e61aeaf4142dda6b8c7ea03a54c3a

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Akademický článek

Caspase-dependent inhibition of mousepox replication by gzmB.

Autor: Julián Pardo, Eva María Gálvez, Aulikki Koskinen, Markus M Simon, Mario Lobigs, Matthias Regner, Arno Müllbacher

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7512 (2009)

BACKGROUND: Ectromelia virus is a natural mouse pathogen, causing mousepox. The cytotoxic T (Tc) cell granule serine-protease, granzyme B, is important for its control, but the underlying mechanism is unknown. Using ex vivo virus immune Tc cells, we

Externí odkaz: https://doaj.org/article/65498792f83d4665b5297cf371e14c8d

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Akademický článek

Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections.

Autor: Mohammed Alsharifi, Yoichi Furuya, Timothy R Bowden, Mario Lobigs, Aulikki Koskinen, Matthias Regner, Lee Trinidad, David B Boyle, Arno Müllbacher

Publikováno v: PLoS ONE, Vol 4, Iss 4, p e5336 (2009)

BACKGROUND: Influenza A (flu) virus causes significant morbidity and mortality worldwide, and current vaccines require annual updating to protect against the rapidly arising antigenic variations due to antigenic shift and drift. In fact, current subu

Externí odkaz: https://doaj.org/article/d7df0ff886154443a74a919693951cdf

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Akademický článek

SARS-CoV-2 Vaccines: Inactivation by Gamma Irradiation for T and B Cell Immunity

Autor: Arno Mullbacher, Julian Pardo, Yoichi Furuya

Publikováno v: Pathogens, Vol 9, Iss 11, p 928 (2020)

Despite accumulating preclinical data demonstrating a crucial role of cytotoxic T cell immunity during viral infections, ongoing efforts on developing COVID-19 vaccines are mostly focused on antibodies. In this commentary article, we discuss potentia

Externí odkaz: https://doaj.org/article/6d622e712cf64590a14608c1eaac82f5

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Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin

Autor: Markus M. Simon, Michael Huber, Praxedis Martin, Klaus Ebnet, Arno Mullbacher, Anne Prins, Reinhard Wallich, Sandra Iden, Aynur Ekiciler, Julián Pardo, H Zentgraf

Publikováno v: Cell Death & Differentiation. 14:1768-1779

Mast cells respond to pathogens and allergens by secreting a vast array of preformed and newly synthesized mediators, including enzymes, vasoactive amines, lipid mediators, cytokines and chemokines, thereby affecting innate and adaptive immune respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031883005e599b6bd184181be2cbfb42
https://doi.org/10.1038/sj.cdd.4402183

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Granzyme A-deficient mice retain potent cell-mediated cytotoxicity

Autor: Marinus C. Lamers, Klaus Ebnet, Lehmann-Grube F, Arno Mullbacher, Hausmann M, Manfred Kopf, Markus M. Simon

Publikováno v: Europe PubMed Central
Scopus-Elsevier

Granzyme A, a granule-associated serine proteinase of activated cytotoxic T cells and natural killer cells, has been reported to play a critical role in DNA fragmentation of target cells. To address the question of the biological role of granzyme A,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9cc23b805f19bb69b202c7e216973b
https://europepmc.org/articles/PMC394506/

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