Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Arno L. Greenleaf"'
Autor:
Malgorzata Krajewska, Ruben Dries, Andrew V. Grassetti, Sofia Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S. Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, Edmond Chipumuro, Tinghu Zhang, Arno L. Greenleaf, Guo-Cheng Yuan, Nathanael S. Gray, Richard A. Young, Matthias Geyer, Scott A. Gerber, Rani E. George
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cdk12 is primarily involved in the regulation of DNA damage response (DDR) gene transcription as well as mRNA processing. Here, the authors demonstrate that CDK12 suppresses intronic polyadenylation, and that inhibition of this kinase primarily affec
Externí odkaz:
https://doaj.org/article/fedbb8762827499baca37a345fd99c5e
Publikováno v:
Biomolecules, Vol 9, Iss 10, p 634 (2019)
We asked whether the C-terminal repeat domain (CTD) kinase, CDK12/CyclinK, phosphorylates substrates in addition to the CTD of RPB1, using our CDK12analog-sensitive HeLa cell line to investigate CDK12 activity-dependent phosphorylation events in huma
Externí odkaz:
https://doaj.org/article/4a2a99b3d3f54660a4a959687788d89f
Autor:
Arno L. Greenleaf
Publikováno v:
Transcription. 10:91-110
As the new millennium began, CDK12 and CDK13 were discovered as nucleotide sequences that encode protein kinases related to cell cycle CDKs. By the end of the first decade both proteins had been qualified as CTD kinases, and it was emerging that both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8d3711097d7fa158fe7f0ed13b5d94
https://doi.org/10.1080/21541264.2018.1535211
https://doi.org/10.1080/21541264.2018.1535211
Autor:
Craig B Bennett, Tammy J Westmoreland, Carmel S Verrier, Carrie A B Blanchette, Tiffany L Sabin, Hemali P Phatnani, Yuliya V Mishina, Gudrun Huper, Alice L Selim, Ernest R Madison, Dominique D Bailey, Adebola I Falae, Alvaro Galli, John A Olson, Arno L Greenleaf, Jeffrey R Marks
Publikováno v:
PLoS ONE, Vol 3, Iss 1, p e1448 (2008)
BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 fun
Externí odkaz:
https://doaj.org/article/4bc481118f46427cb111886447c1d4de
Autor:
Nathanael S. Gray, Edmond Chipumuro, Ruben Dries, Guo-Cheng Yuan, Matthias Geyer, Richard A. Young, Arno L. Greenleaf, Yang Gao, Scott A. Gerber, Rani E. George, Tinghu Zhang, Oliver Dodd, Andrew V. Grassetti, Hao Huang, Małgorzata Krajewska, Sofia Dust, Nicholas Kwiatkowski, Bandana Sharma, Monica Pomaville, Daniel S. Day
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of genes involved in the DNA damage response (DDR) and mRNA processing. Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741ed814d9ce88c3bc8889aa75745c2a
https://doi.org/10.1101/483958
https://doi.org/10.1101/483958
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1849:1179-1187
The RNA Polymerase II C-terminal domain (CTD) kinase CDK12 has been implicated as a tumor suppressor and regulator of DNA damage response genes. Although much has been learned about CDK12 and its activity, due to the lack of a specific inhibitor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf29e6e7a5c307a189d06b831694a47
https://doi.org/10.1016/j.bbagrm.2015.07.010
https://doi.org/10.1016/j.bbagrm.2015.07.010
Publikováno v:
The Journal of Biological Chemistry
Background: CDK12 helps to regulate DNA transcription and associated processes. Results: Full-length and active CDK12 can be expressed using baculovirus and CDK12 interacts with many RNA processing factors. Conclusion: CDK12 may affect RNA processing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7158bb113f397cbd4c929db0a0d021b
http://europepmc.org/articles/PMC4340420
http://europepmc.org/articles/PMC4340420
Publikováno v:
Biomolecules
Volume 9
Issue 10
Biomolecules, Vol 9, Iss 10, p 634 (2019)
Volume 9
Issue 10
Biomolecules, Vol 9, Iss 10, p 634 (2019)
We asked whether the C-terminal repeat domain (CTD) kinase, CDK12/CyclinK, phosphorylates substrates in addition to the CTD of RPB1, using our CDK12analog-sensitive HeLa cell line to investigate CDK12 activity-dependent phosphorylation events in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38263d6dbb32480ff3295586d4f5cdf
https://doi.org/10.3390/biom9100634
https://doi.org/10.3390/biom9100634
Publikováno v:
Journal of Biological Chemistry. 288:10890-10901
The human transcription elongation regulator TCERG1 physically couples transcription elongation and splicing events by interacting with splicing factors through its N-terminal WW domains and the hyperphosphorylated C-terminal domain (CTD) of RNA poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9515ccd8832d6f0617d6d2e1cb723ca7
https://doi.org/10.1074/jbc.m113.460238
https://doi.org/10.1074/jbc.m113.460238
Cotranscriptional Association of mRNA Export Factor Yra1 with C-terminal Domain of RNA Polymerase II
Autor:
Arno L. Greenleaf, April L. MacKellar
Publikováno v:
Journal of Biological Chemistry. 286:36385-36395
The unique C-terminal domain (CTD) of RNA polymerase II, composed of tandem heptad repeats of the consensus sequence YSPTSPS, is subject to differential phosphorylation throughout the transcription cycle. Several RNA processing factors have been show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8d14de1db89444a15765bad31591f5
https://doi.org/10.1074/jbc.m111.268144
https://doi.org/10.1074/jbc.m111.268144