Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Arno L Greenleaf"'
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60909 (2013)
RNA polymerase II translocates across much of the genome and since it can be blocked by many kinds of DNA lesions, detects DNA damage proficiently; it thereby contributes to DNA repair and to normal levels of DNA damage resistance. However, the compo
Externí odkaz:
https://doaj.org/article/842d140183d0487fa03126abb5f4214f
Autor:
Tammy J Westmoreland, Sajith M Wickramasekara, Andrew Y Guo, Alice L Selim, Tiffany S Winsor, Arno L Greenleaf, Kimberly L Blackwell, John A Olson, Jeffrey R Marks, Craig B Bennett
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5830 (2009)
The chemotherapeutic doxorubicin (DOX) induces DNA double-strand break (DSB) damage. In order to identify conserved genes that mediate DOX resistance, we screened the Saccharomyces cerevisiae diploid deletion collection and identified 376 deletion st
Externí odkaz:
https://doaj.org/article/7e3c66acc2fb4792a627abbf418cf73e
Autor:
Craig B Bennett, Tammy J Westmoreland, Carmel S Verrier, Carrie A B Blanchette, Tiffany L Sabin, Hemali P Phatnani, Yuliya V Mishina, Gudrun Huper, Alice L Selim, Ernest R Madison, Dominique D Bailey, Adebola I Falae, Alvaro Galli, John A Olson, Arno L Greenleaf, Jeffrey R Marks
Publikováno v:
PLoS ONE, Vol 3, Iss 1, p e1448 (2008)
BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 fun
Externí odkaz:
https://doaj.org/article/4bc481118f46427cb111886447c1d4de
Autor:
Nathanael S. Gray, Edmond Chipumuro, Ruben Dries, Guo-Cheng Yuan, Matthias Geyer, Richard A. Young, Arno L. Greenleaf, Yang Gao, Scott A. Gerber, Rani E. George, Tinghu Zhang, Oliver Dodd, Andrew V. Grassetti, Hao Huang, Małgorzata Krajewska, Sofia Dust, Nicholas Kwiatkowski, Bandana Sharma, Monica Pomaville, Daniel S. Day
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of genes involved in the DNA damage response (DDR) and mRNA processing. Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741ed814d9ce88c3bc8889aa75745c2a
https://doi.org/10.1101/483958
https://doi.org/10.1101/483958
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1849:1179-1187
The RNA Polymerase II C-terminal domain (CTD) kinase CDK12 has been implicated as a tumor suppressor and regulator of DNA damage response genes. Although much has been learned about CDK12 and its activity, due to the lack of a specific inhibitor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf29e6e7a5c307a189d06b831694a47
https://doi.org/10.1016/j.bbagrm.2015.07.010
https://doi.org/10.1016/j.bbagrm.2015.07.010
Publikováno v:
Biomolecules
Volume 9
Issue 10
Biomolecules, Vol 9, Iss 10, p 634 (2019)
Volume 9
Issue 10
Biomolecules, Vol 9, Iss 10, p 634 (2019)
We asked whether the C-terminal repeat domain (CTD) kinase, CDK12/CyclinK, phosphorylates substrates in addition to the CTD of RPB1, using our CDK12analog-sensitive HeLa cell line to investigate CDK12 activity-dependent phosphorylation events in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38263d6dbb32480ff3295586d4f5cdf
https://doi.org/10.3390/biom9100634
https://doi.org/10.3390/biom9100634
Publikováno v:
Journal of Biological Chemistry. 288:10890-10901
The human transcription elongation regulator TCERG1 physically couples transcription elongation and splicing events by interacting with splicing factors through its N-terminal WW domains and the hyperphosphorylated C-terminal domain (CTD) of RNA poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9515ccd8832d6f0617d6d2e1cb723ca7
https://doi.org/10.1074/jbc.m113.460238
https://doi.org/10.1074/jbc.m113.460238
Publikováno v:
Molecular Biology and Evolution. 27:2628-2641
With a simple tandem iterated sequence, the carboxyl terminal domain (CTD) of eukaryotic RNA polymerase II (RNAP II) serves as the central coordinator of mRNA synthesis by harmonizing a diversity of sequential interactions with transcription and proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d802e159e7fd90528e5ef20b72548f46
https://doi.org/10.1093/molbev/msq151
https://doi.org/10.1093/molbev/msq151
Autor:
Nathanael S. Gray, Jonathan M. Elkins, Theresa D. Manz, Ann Katrin Greifenberg, Richard A. Young, Alex N. Bullock, Arno L. Greenleaf, Nancy M. Hannett, Jarrod A. Marto, Scott B. Ficarro, Nicholas Kwiatkowski, Matthias Geyer, Bartlomiej Bartkowiak, Mingfeng Hao, Yanke Liang, S. Dixon-Clarke, Calla M. Olson, Brian J. Abraham, Tinghu Zhang
Publikováno v:
Nature Chemical Biology
Cyclin-dependent kinases 12 and 13 (CDK12 and CDK13) play critical roles in the regulation of gene transcription. However, the absence of CDK12 and CDK13 inhibitors has hindered the ability to investigate the consequences of their inhibition in healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1d1ceae14699bb4312d0f1d7c35b14
https://pubmed.ncbi.nlm.nih.gov/27649053
https://pubmed.ncbi.nlm.nih.gov/27649053
Autor:
Arno L. Greenleaf, David A. Skaar
Publikováno v:
Molecular Cell. 10(6):1429-1439
There are several kinases in Saccharomyces cerevisiae that phosphorylate the CTD of RNA polymerase II, but specific and distinct functions of the phospho-CTDs generated by the different kinases are not well understood. A genetic screen for suppressor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064383283a66938259d46c45aeca812f