Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Arno FRIEDLEIN"'
Autor:
Veronica Costa, Stefan Aigner, Mirko Vukcevic, Evelyn Sauter, Katharina Behr, Martin Ebeling, Tom Dunkley, Arno Friedlein, Sannah Zoffmann, Claas A. Meyer, Frédéric Knoflach, Sebastian Lugert, Christoph Patsch, Fatiha Fjeldskaar, Laurie Chicha-Gaudimier, Anna Kiialainen, Paolo Piraino, Marc Bedoucha, Martin Graf, Sebastian Jessberger, Anirvan Ghosh, Josef Bischofberger, Ravi Jagasia
Publikováno v:
Cell Reports, Vol 15, Iss 1, Pp 86-95 (2016)
Hyperfunction of the mTORC1 pathway has been associated with idiopathic and syndromic forms of autism spectrum disorder (ASD), including tuberous sclerosis, caused by loss of either TSC1 or TSC2. It remains largely unknown how developmental processes
Externí odkaz:
https://doaj.org/article/c453283d07954edc80795548e6cfa550
Autor:
Stepánka Vanácová, Jeannette Wolf, Georges Martin, Diana Blank, Sabine Dettwiler, Arno Friedlein, Hanno Langen, Gérard Keith, Walter Keller
Publikováno v:
PLoS Biology, Vol 3, Iss 6, p e189 (2005)
Eukaryotic cells contain several unconventional poly(A) polymerases in addition to the canonical enzymes responsible for the synthesis of poly(A) tails of nuclear messenger RNA precursors. The yeast protein Trf4p has been implicated in a quality cont
Externí odkaz:
https://doaj.org/article/30a6f292345f4fb89edeac397c43fc02
Autor:
Frédéric Knoflach, Sannah Jensen Zoffmann, Martin Ebeling, Mirko Vukcevic, Christoph Patsch, Claas A. Meyer, Tom Dunkley, Laurie Chicha-Gaudimier, Katharina Behr, Josef Bischofberger, Anna Kiialainen, Ravi Jagasia, Sebastian Jessberger, Veronica Costa, Paolo Piraino, Martin Graf, Fatiha Fjeldskaar, Marc Bedoucha, Sebastian Lugert, Stefan Aigner, Evelyn Sauter, Anirvan Ghosh, Arno Friedlein
Publikováno v:
Cell Reports, Vol 15, Iss 1, Pp 86-95 (2016)
SummaryHyperfunction of the mTORC1 pathway has been associated with idiopathic and syndromic forms of autism spectrum disorder (ASD), including tuberous sclerosis, caused by loss of either TSC1 or TSC2. It remains largely unknown how developmental pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcebef63545b1b30e464198171d1577
Autor:
Roberto Iacone, Frederic Delobel, Verena Kueppers, Sascha Fauser, Peter Jakob, Esther Melo, Peter Goettig, Chia-yi Chen, Tom Dunkley, Brigitta Elsässer, Oliver Schilling, Arno Friedlein, Corinne Stucki
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population. Variants in the HTRA1-ARMS2 locus have been linked to increased AMD risk. In the present study we investigated the impact of elevated Htr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fcd7a1ff777817f7be54cc9b2443217
https://eplus.uni-salzburg.at/doi/10.1016/j.matbio.2018.03.013
https://eplus.uni-salzburg.at/doi/10.1016/j.matbio.2018.03.013
Autor:
Arno Friedlein, Sebastian Lugert, Stefan Aigner, Paul Cutler, Martin Ebeling, Veronica Costa, Meghan T. Miller, Paolo Piraino, Christoph Patsch, Ravi Jagasia, Tom Dunkley
Publikováno v:
PROTEOMICS - Clinical Applications. 9:684-694
Purpose Human pluripotent stem cell (hPSC)-derived cellular models have great potential to enable drug discovery and improve translation of preclinical insights to the clinic. We have developed a hPSC-derived neural precursor cell model for studying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d650c8f3f20ebc9d63c690d85d365d4
https://doi.org/10.1002/prca.201400150
https://doi.org/10.1002/prca.201400150
Autor:
Tara Williamson, Jens Lamerz, Peter Jakob, Thierry Lavé, Paul Cutler, Roberto Tolando, Stephen Fowler, Arno Friedlein, Aki T. Heikkinen, Neil Parrott
Publikováno v:
Pharmaceutical Research. 29:1832-1842
Physiologically based models, when verified in pre-clinical species, optimally predict human pharmacokinetics. However, modeling of intestinal metabolism has been a gap. To establish in vitro/in vivo scaling factors for metabolism, the expression and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9edd14ded457f0693713c48223b7e9
https://doi.org/10.1007/s11095-012-0707-7
https://doi.org/10.1007/s11095-012-0707-7
Autor:
Aleksandra Galetin, Ruedi Aebersold, Aleksanteri Petsalo, Mariette Matondo, Oliver Hatley, Aki T. Heikkinen, Neil Parrott, Jens Lamerz, Paul Cutler, Amin Rostami-Hodjegan, Arno Friedlein, Risto O. Juvonen, Tom Dunkley
Publikováno v:
Pharmaceutical Research
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2015, 32 (1), pp.74-90. ⟨10.1007/s11095-014-1446-8⟩
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2015, 32 (1), pp.74-90. ⟨10.1007/s11095-014-1446-8⟩
International audience; PURPOSE:Beagle dogs are used to study oral pharmacokinetics and guide development of drug formulations for human use. Since mechanistic insight into species differences is needed to translate findings in this species to human,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257c5cba2077adb8e58c7d78d4df4281
https://hal-pasteur.archives-ouvertes.fr/pasteur-02573666
https://hal-pasteur.archives-ouvertes.fr/pasteur-02573666
Autor:
Jeremy L. Norris, Dale S. Cornett, Angélique Augustin, Arno Friedlein, Richard M. Caprioli, Stefan Ruepp, Maria Cristina De Vera Mudry, Annette R. Erskine, Hélène Meistermann, Hanno Langen, Laura Suter, Axel Ducret, Hans R. Aerni
Publikováno v:
Molecular & Cellular Proteomics. 5:1876-1886
Adverse drug effects are often associated with pathological changes in tissue. An accurate depiction of the undesired affected area, possibly supported by mechanistic data, is important to classify the effects with regard to relevance for human patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d7cfc0c6f134bcf3df06bf2a244bd8
https://doi.org/10.1074/mcp.m500399-mcp200
https://doi.org/10.1074/mcp.m500399-mcp200
Publikováno v:
Molecular Cell. 23(2):195-205
Eukaryotic pre-mRNAs are capped at their 5' ends, polyadenylated at their 3' ends, and spliced before being exported from the nucleus to the cytoplasm. Although the three processing reactions can be studied separately in vitro, they are coupled in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de232cfa2307ee678988051718b7df26
Publikováno v:
PROTEOMICS. 6:2924-2930
The most common human brain tumours - gliomas - have poor prognosis with and without treatment. The current therapy conditions act sub-lethally and cannot effectively suppress the proliferation of glioma cells. Here we show differential protein expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b3c1f55cc23af5d756ceeb67073bcb
https://doi.org/10.1002/pmic.200500587
https://doi.org/10.1002/pmic.200500587