Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Arno F. Spatola"'
Autor:
Peteris Romanovskis, Arno F. Spatola
Publikováno v:
The Journal of Peptide Research. 52:356-374
Cyclic peptide mixtures represent a promising approach for drug lead discovery. Diversity can be expanded via changes in ring size, amide bond replacements, D- and L-natural and unnatural amino acids, and by the incorporation of beta-turn mimics and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defad42d47a65bc19977ed10505d5775
https://doi.org/10.1111/j.1399-3011.1998.tb00660.x
https://doi.org/10.1111/j.1399-3011.1998.tb00660.x
Publikováno v:
International Journal of Peptide and Protein Research. 40:322-332
Relatively small cyclic peptides that contain functionalized side chains provide interesting model compounds for studying side chain-side chain interactions, peptide backbone flexibility (especially if X-Pro bonds are included), and as potential enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b23189429358242c23efc302aa69baa7
https://doi.org/10.1111/j.1399-3011.1992.tb00308.x
https://doi.org/10.1111/j.1399-3011.1992.tb00308.x
Publikováno v:
International Journal of Peptide and Protein Research. 30:489-497
Dehalogenation of chlorine bound to aromatic nuclei has been achieved using ammonium formate-catalytic transfer hydrogenation (AF-CTH) techniques. The use of deuterated ammonium formate as the transfer agent in the CTH process when performed in a deu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08bbc4c382e5f0b0f88c4736582baa5f
https://doi.org/10.1111/j.1399-3011.1987.tb03357.x
https://doi.org/10.1111/j.1399-3011.1987.tb03357.x
Autor:
Amit K. Galande, Arno F. Spatola, John O. Trent, Thomas P. Burris, Kelli S. Bramlett, James L. Wittliff
Publikováno v:
ChemBioChem. 6:1991-1998
Protein-protein interactions between estrogen receptors, ERalpha and ERbeta, and their coactivators (CoAs) are an attractive target for drug intervention. This interaction is mediated by a small pentapeptide motif (LXXLL), termed the NR box. Based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff5da20dd7cb4db1157a4fd434f7a9b
https://doi.org/10.1002/cbic.200500083
https://doi.org/10.1002/cbic.200500083
Autor:
James G. Cripps, Rafael Fernandez-Botran, Peteris Romanovskis, Fabian A Crespo, Arno F. Spatola
Publikováno v:
International Immunopharmacology. 5:1622-1632
Glycosaminoglycans (GAGs) located on cellular membranes and the extracellular matrix (ECM) are able to interact with chemokines and pro-inflammatory cytokines, leading to local cytokine/chemokine accumulation. The tissue-bound cytokines/chemokines fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65daf8dba15ffe2de63e4a9f97e4ba0b
https://doi.org/10.1016/j.intimp.2005.04.010
https://doi.org/10.1016/j.intimp.2005.04.010
Autor:
F.M. Brunel, Arno F. Spatola
Publikováno v:
Journal of Peptide Research. 63:213-222
Enantiomerically pure N-methylated diketopiperazines (DKP) can be obtained by treating a N-methylated resin-bound dipeptide with 20% piperidine in dimethylformamide via a process known as cyclative release. N-methylated resin-bound dipeptides can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b839d555f9b8362049a6beb674ed7220
https://doi.org/10.1111/j.1399-3011.2004.00130.x
https://doi.org/10.1111/j.1399-3011.2004.00130.x
Publikováno v:
The Journal of Peptide Research. 63:56-62
Glycosaminoglycans (GAGs) play an important role in inflammatory responses due to their ability to interact with cytokines and chemokines, resulting in the localization of these mediators to specific anatomical sites, where they function to direct le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42d952f86d5477aabecc2eb645cc1072
https://doi.org/10.1111/j.1399-3011.2003.00107.x
https://doi.org/10.1111/j.1399-3011.2003.00107.x
Autor:
Arno F. Spatola, Joseph L. Johnson, Peteris Romanovskis, Elizabeth H. McCullough, Thomas F. Hughes, Bernadette Cusack, Abdul H. Fauq, Terrone L. Rosenberry
Publikováno v:
Journal of Biological Chemistry. 278:38948-38955
The acetylcholinesterase (AChE) active site consists of a narrow gorge with two separate ligand binding sites: an acylation site (or A-site) at the bottom of the gorge where substrate hydrolysis occurs and a peripheral site (or P-site) at the gorge m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd55a12e012b20273b0496da6bc63c4b
https://doi.org/10.1074/jbc.m304797200
https://doi.org/10.1074/jbc.m304797200
Autor:
John O. Trent, Anne-Marie Leduc, Thomas P. Burris, Yong Wang, Nikolay Y. Chirgadze, Stephen L. Briggs, James L. Wittliff, Arno F. Spatola, Kelli S. Bramlett
Publikováno v:
Proceedings of the National Academy of Sciences. 100:11273-11278
The interaction between nuclear receptors and coactivators provides an arena for testing whether protein–protein interactions may be inhibited by small molecule drug candidates. We provide evidence that a short cyclic peptide, containing a copy of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0412613e3684f98910895442869e2c3f
https://doi.org/10.1073/pnas.1934759100
https://doi.org/10.1073/pnas.1934759100
Publikováno v:
Biopolymers. 71:534-551
A recently rediscovered reaction of base-assisted lanthionine formation has been applied to several systems of disulfide-bridged peptides. In addition to previously described nonapeptides consisting of i, i+3 cystine linkages, the reaction has now be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ee1a6399fbf19f61c9a2b5c36d1094
https://doi.org/10.1002/bip.10532
https://doi.org/10.1002/bip.10532