Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Arnika Rehbein"'
Autor:
Sven D. Koch, Karin Hähnel, Graham Pawelec, H. Griesemann, Arnika Rehbein, Cécile Gouttefangeas
Publikováno v:
Cancer Immunology, Immunotherapy. 55:981-986
There are good arguments for suggesting that two seminal papers published 50 years ago can be taken as the beginning of modern tumour immunology. These papers by R. Baldwin, "Immunity to transplanted tumour: the effect of tumour extracts on the growt
Publikováno v:
Vaccine. 18:1666-1674
Immunosenescence is an age-associated dysregulation of immune function which may contribute to the increased susceptibility of the elderly to infectious disease. Although age-associated changes are measurable in the innate immune system, it is the ad
Publikováno v:
Experimental Gerontology. 34:69-77
Several studies have documented finite lifespans of at least the vast majority of cultured human T cell lines and clones. However, there is a great deal of variation among the different preparations, ranging from25 PD up to100 PD. The cultured T cell
Publikováno v:
Immunological Reviews. 160:31-42
We have consistently observed that like other normal somatic tissue cells, human T lymphocytes manifest a finite proliferative capacity in culture in vitro. When measured in population doublings (PD), this averages about 35 PD for T-cell clones (TCC)
Publikováno v:
Experimental Gerontology. 31:655-668
The growth characteristics in vitro of interleukin 2 (IL 2)-dependent human CD4+ alpha beta-T cell receptor-positive helper T cell clones (TCC) were studied in relation to alterations in surface phenotype, cytokine responsiveness, and susceptibility
Publikováno v:
Transplantation. 62:1095-1101
Organ graft rejection is caused by the recognition of allogeneic MHC molecules by recipient T cells by two different pathways. The indirect pathway of alloreactivity requires the presentation of MHC peptides from the graft by autologous APC, as with
Publikováno v:
Cancer Immunology, Immunotherapy. 42:193-199
Using a modification of the autologous mixed lymphocyte/tumour cell culture (MLTC), it is demonstrated here that lymphocytes from chronic-phase myelogenous leukaemia (CML) patients (n = 58), but not from their HLA-identical siblings, proliferated upo
Publikováno v:
Mechanisms of Ageing and Development. 83:171-183
Human monoclonal T lymphocyte populations maintained in long-term culture by intermittent reactivation via the antigen receptor and supplied with exogenous interleukin 2 manifest finite proliferative lifespans. T lymphocytes cloned from mature periph
Autor:
Hilke Friccius, Elke Schlotz, David M. Sansom, Petra Siegels-Hübenthal, Heike Pohla, Kurt Schaudt, Graham Pawelec, Arnika Rehbein, Martina Boshell
Publikováno v:
Cellular Immunology. 162:8-15
A condition of hyporesponsiveness can be induced in certain mature human αβ (TCR2) cells relatively easily by their stimulation in the absence of costimulatory signals (signal 1 alone). This state of "anergy" has been implicated in tolerance to sel
Autor:
Petra Siegels-Hübenthal, Kurt Schaudt, Medi Adibzadeh, Graham Pawelec, Hans-Jörg Bühring, Heike Pohla, Martin Owsianowsky, Arnika Rehbein, Andrea Schenk, Elke Schlotz, Thomas Deikeler
Publikováno v:
Developmental Immunology
In order to study extrathymic differentiationin vitro, CD7+CD3-lymphocytes were sorted from normal human bone marrow and cultured under conditions of limiting dilution together with irradiated pooled allogeneic peripheral blood mononuclear cells (PBM