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Akademický článek

Mapping conformational changes on bispecific antigen-binding biotherapeutic by covalent labeling and mass spectrometry

Autor: Arnik Shah, Dipanwita Batabyal, Dayong Qiu, Weidong Cui, John Harrahy, Alexander R. Ivanov

Publikováno v: Journal of Pharmaceutical Analysis, Vol 14, Iss 8, Pp 100966- (2024)

Biotherapeutic's higher order structure (HOS) is a critical determinant of its functional properties and conformational relevance. Here, we evaluated two covalent labeling methods: diethylpyrocarbonate (DEPC)-labeling and fast photooxidation of prote

Externí odkaz: https://doaj.org/article/8af40caf50274687a4fde890db80b3b3

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Characterization of bispecific antigen-binding biotherapeutic fragmentation sites using microfluidic capillary electrophoresis coupled to mass spectrometry (mCZE-MS)

Autor: Arnik Shah, Ruhi Desai, Weidong Cui, John J. Harrahy, Alexander R. Ivanov

Publikováno v: The Analyst. 148:665-674

Microfluidic capillary zone electrophoresis coupled to mass spectrometry enables improved throughput, resolution, and sensitivity in characterization of 12–40 kDa bispecific antigen-binding biotherapeutic fragments compared to traditional methods.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::402d78248f779f97efe0b45913800654
https://doi.org/10.1039/d2an01724e

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