Výsledky vyhledávání - "Arni Gagnidze"

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

Autor: Danijel Djukovic, Ying Ann Chiao, Nathan Basisty, Daniel Raftery, Julia Zhang, Haiwei Gu, Arni Gagnidze, Stephen C. Kolwicz, Richard P. Beyer, Michael J. MacCoss, Peter S. Rabinovitch, Rong Tian

Publikováno v: Aging (Albany NY)
Scopus-Elsevier

Rapamycin, an inhibitor of mTOR signaling, has been shown to reverse diastolic dysfunction in old mice in 10 weeks, highlighting its therapeutic potential for a poorly treatable condition. However, the mechanisms and temporal regulation of its cardia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e59701ad155525797500f1fb4a62532
https://doi.org/10.18632/aging.100881

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Preoperative Low-Dose Aspirin Exposure and Outcomes After Emergency Neurosurgery for Traumatic Intracranial Hemorrhage in Elderly Patients

Autor: Monica S. Vavilala, Irene Rozet, Alon Ben-Ari, Alex T. Lee, Kevin C. Cain, Bala G. Nair, Arni Gagnidze, Sharon R. Pan, Shu Fang Newman, Ahmed Zaky, Pimwan Sookplung

Publikováno v: Anesthesia and analgesia. 125(2)

Antiplatelet medications are usually discontinued before elective neurosurgery, but this is not an option for emergent neurosurgery. We performed a retrospective cohort study to examine whether preoperative aspirin use was associated with worse outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0afbb8f887997ef8b406311c5b3ab7
https://pubmed.ncbi.nlm.nih.gov/28504994

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mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome

Autor: Matt Kaeberlein, Ernst Bernhard Kayser, Melana E. Yanos, Lauren Uhde, Philip G. Morgan, Richard D. Palmiter, Simon C. Johnson, Kelly Oh, Maya Sangesland, Margaret M. Sedensky, Brian M. Wasko, Albert Quintana, Valerie Z. Wall, Peter S. Rabinovitch, Anthony S. Castanza, Fresnida J. Ramos, Arni Gagnidze, Jessica Hui

Publikováno v: Science (New York, N.Y.). 342(6165)

More from mTOR Leigh syndrome is a rare, untreatable, inherited neurodegenerative disease in children that is caused by functional disruption of mitochondria, the cell's energy-producing organelles. Johnson et al. (p. 1524 , published online 14 Novem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0fbbc97498d1c4abc33ab36b00f040
https://pubmed.ncbi.nlm.nih.gov/24357304

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