Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Arne van Hoeck"'
Autor:
Nicolle Besselink, Janneke Keijer, Carlo Vermeulen, Sander Boymans, Jeroen de Ridder, Arne van Hoeck, Edwin Cuppen, Ewart Kuijk
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract DNA methylation is important for establishing and maintaining cell identity and for genomic stability. This is achieved by regulating the accessibility of regulatory and transcriptional elements and the compaction of subtelomeric, centromeri
Externí odkaz:
https://doaj.org/article/a222b675a2064a8d8a7fbc7905355b5f
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Specific anti-cancer therapies are highly mutagenic to cancer cells but the mutational impact on healthy tissues remains elusive. Here, the authors use organoids and whole-genome sequencing to characterise somatic mutations in healthy colon and liver
Externí odkaz:
https://doaj.org/article/ca064644a36449b692e6323f5bc540c5
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The original tumor location can be unclear for metastatic tumors. Here, the authors show that DNA sequencing of whole genomes can be used to classify metastatic tumors using a machine learning model, Cancer of Unknown Primary Location Resolver, in or
Externí odkaz:
https://doaj.org/article/a0c0598665cd44c6bf62290d8c3aab3b
Autor:
Freek Manders, Arianne M. Brandsma, Jurrian de Kanter, Mark Verheul, Rurika Oka, Markus J. van Roosmalen, Bastiaan van der Roest, Arne van Hoeck, Edwin Cuppen, Ruben van Boxtel
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background The collective of somatic mutations in a genome represents a record of mutational processes that have been operative in a cell. These processes can be investigated by extracting relevant mutational patterns from sequencing data. R
Externí odkaz:
https://doaj.org/article/2850a20877ff45f2957546fea6286f10
Autor:
Daniel L. Cameron, Jonathan Baber, Charles Shale, Jose Espejo Valle-Inclan, Nicolle Besselink, Arne van Hoeck, Roel Janssen, Edwin Cuppen, Peter Priestley, Anthony T. Papenfuss
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-25 (2021)
Abstract GRIDSS2 is the first structural variant caller to explicitly report single breakends—breakpoints in which only one side can be unambiguously determined. By treating single breakends as a fundamental genomic rearrangement signal on par with
Externí odkaz:
https://doaj.org/article/de3ce335851f477d87508e83a6c69c6c
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Currently available tools for the analysis of mutational signatures do not make use of all possible genomic properties aside from mutation patterns. Here the authors present TensorSignatures, an efficient framework that jointly infers mutational sign
Externí odkaz:
https://doaj.org/article/2405297639f64e50aa0d98e47f6b0bb5
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cancers deficient in homologous recombination can benefit from treatment with poly ADP-ribose polymerase (PARP) inhibitors. Here, the authors generated a classifier that can predict homologous recombination deficiency from genomic data and suggest se
Externí odkaz:
https://doaj.org/article/3e18fff65acc4455b9f7724c9219a647
Autor:
Laura C. Demmers, Kai Kretzschmar, Arne Van Hoeck, Yotam E. Bar-Epraïm, Henk W. P. van den Toorn, Mandy Koomen, Gijs van Son, Joost van Gorp, Apollo Pronk, Niels Smakman, Edwin Cuppen, Hans Clevers, Albert J. R. Heck, Wei Wu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Immunotherapy may exploit alternative vulnerabilities of drug resistant cells. Here, the authors show that the HLA peptide presentation landscape is heterogeneous even within one individual, hinting that a multi-peptide vaccination approach against h
Externí odkaz:
https://doaj.org/article/0f1b88b0b588494fb19b8fcb86e2abed
Autor:
Ewart Kuijk, Myrthe Jager, Bastiaan van der Roest, Mauro D. Locati, Arne Van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle Besselink, Sander Boymans, Ruben van Boxtel, Edwin Cuppen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Genetic changes acquired during in vitro culture pose a challenge to application of stem cells. Here the authors use whole genome sequencing to show that cultured human adult and pluripotent stem cells have a high mutational load caused by oxidative
Externí odkaz:
https://doaj.org/article/1f6a475491464666a79c0e3f7512c41e
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
During life, the DNA of our cells is continuously exposed to external damaging processes. Despite the activity of various repair mechanisms, DNA damage eventually results in the accumulation of mutations in the genomes of our cells. Oncogenic mutatio
Externí odkaz:
https://doaj.org/article/59378ae681d2459b9ab4352472d5a18f