Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Arne Zibat"'
Autor:
Wiebke Maurer, Sabine Rebs, Steffen Köhne, Hanna Eberl, Bernd Wollnik, Arne Zibat, Katrin Streckfuss-Bömeke
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103409- (2024)
Filamin C (FLNC) is a highly important actin crosslinker and multi-adaptor protein in striated skeletal and cardiac muscle. Mutations have been linked to a range of cardiomyopathy types. Here, we generated induced pluripotent stem cells (iPSC) from a
Externí odkaz:
https://doaj.org/article/ef95fefded4444bb90e7254eefffb8eb
Autor:
Arne Zibat, Xiaoxiao Zhang, Antje Dickmanns, Kim M. Stegmann, Adrian W. Dobbelstein, Halima Alachram, Rebecca Soliwoda, Gabriela Salinas, Uwe Groß, Dirk Görlich, Maik Kschischo, Bernd Wollnik, Matthias Dobbelstein
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107786- (2023)
Summary: N4-hydroxycytidine (NHC), the active compound of the drug Molnupiravir, is incorporated into SARS-CoV-2 RNA, causing false base pairing. The desired result is an “error catastrophe,” but this bears the risk of mutated virus progeny. To a
Externí odkaz:
https://doaj.org/article/e6f4cd40f75443999577c2a955f4834d
Autor:
Claudia Koch, Andra Kuske, Simon A Joosse, Gökhan Yigit, George Sflomos, Sonja Thaler, Daniel J Smit, Stefan Werner, Kerstin Borgmann, Sebastian Gärtner, Parinaz Mossahebi Mohammadi, Laura Battista, Laure Cayrefourcq, Janine Altmüller, Gabriela Salinas‐Riester, Kaamini Raithatha, Arne Zibat, Yvonne Goy, Leonie Ott, Kai Bartkowiak, Tuan Zea Tan, Qing Zhou, Michael R Speicher, Volkmar Müller, Tobias M Gorges, Manfred Jücker, Jean‐Paul Thiery, Cathrin Brisken, Sabine Riethdorf, Catherine Alix‐Panabières, Klaus Pantel
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp n/a-n/a (2020)
Abstract Functional studies giving insight into the biology of circulating tumor cells (CTCs) remain scarce due to the low frequency of CTCs and lack of appropriate models. Here, we describe the characterization of a novel CTC‐derived breast cancer
Externí odkaz:
https://doaj.org/article/6fcb45740e9c4955a376a11179160a9e
Autor:
Kim Brügger, Lanming Chen, Markus Stark, Arne Zibat, Peter Redder, Andreas Ruepp, Mariana Awayez, Qunxin She, Roger A. Garrett, Hans-Peter Klenk
Publikováno v:
Archaea, Vol 2, Iss 2, Pp 127-135 (2007)
Hyperthermus butylicus, a hyperthermophilic neutrophile and anaerobe, is a member of the archaeal kingdom Crenarchaeota. Its genome consists of a single circular chromosome of 1,667,163 bp with a 53.7% G+C content. A total of 1672 genes were annotate
Externí odkaz:
https://doaj.org/article/99840aecc318434e98c0e4197b010f0e
Autor:
Heidi Hahn, Walter Schulz-Schaeffer, Fritz Aberger, Tobias Pukrop, Julia Reifenberger, Stefan Klingler, Anja Uhmann, Anke Frommhold, Per-Ole Carstens, Felix H. Brembeck, Albert Rosenberger, Mark Wijgerde, Simone König, Arne Zibat, Frauke Nitzki
Supplementary Methods, Tables 1-2 and Figures from Tumor Stroma–Derived Wnt5a Induces Differentiation of Basal Cell Carcinoma of Ptch-Mutant Mice via CaMKII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0683584dd86c9cbcdbb7a9fb1bb38472
https://doi.org/10.1158/0008-5472.22387313.v1
https://doi.org/10.1158/0008-5472.22387313.v1
Autor:
Ina Heß, Arne Zibat, Rolf Buslei, Nadine Brandes, Alexander Wolff, Anke Frommhold, Dominik Simon Botermann, Anja Uhmann, Heidi Hahn
Publikováno v:
The Journal of Endocrinology
Ubiquitous overactivation of Hedgehog signaling in adult pituitaries results in increased expression of proopiomelanocortin (Pomc), growth hormone (Gh) and prolactin (Prl), elevated adrenocorticotropic hormone (Acth) production and proliferation of S
Autor:
Nina Bögershausen, Hannah E. Krawczyk, Rami A. Jamra, Sheng‐Jia Lin, Gökhan Yigit, Irina Hüning, Anna M. Polo, Barbara Vona, Kevin Huang, Julia Schmidt, Janine Altmüller, Johannes Luppe, Konrad Platzer, Beate B. Dörgeloh, Andreas Busche, Saskia Biskup, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Arne Zibat, Eva Bültmann, Peter Nürnberg, Malte Spielmann, Johannes R. Lemke, Yun Li, Martin Zenker, Gaurav K. Varshney, Hauke S. Hillen, Christian P. Kratz, Bernd Wollnik
Publikováno v:
Human Mutations
Human mutation, 43(10), 1454-1471. Wiley-Liss Inc.
Human Mutation, 43(10), 1454-1471. Wiley-Liss Inc.
Bögershausen, N, Krawczyk, H E, Jamra, R A, Lin, S-J, Yigit, G K, Hüning, I, Polo, A M, Vona, B, Huang, K, Schmidt, J, Altmüller, J, Luppe, J, Platzer, K, Dörgeloh, B B, Busche, A, Biskup, S, Mendes, M I, Smith, D E C, Salomons, G S, Zibat, A, Bültmann, E, Nürnberg, P, Spielmann, M, Lemke, J R, Li, Y, Zenker, M, Varshney, G K, Hillen, H S, Kratz, C P & Wollnik, B 2022, ' WARS1 and SARS1 : Two tRNA synthetases implicated in autosomal recessive microcephaly ', Human Mutation, vol. 43, no. 10, pp. 1454-1471 . https://doi.org/10.1002/humu.24430
Human mutation, 43(10), 1454-1471. Wiley-Liss Inc.
Human Mutation, 43(10), 1454-1471. Wiley-Liss Inc.
Bögershausen, N, Krawczyk, H E, Jamra, R A, Lin, S-J, Yigit, G K, Hüning, I, Polo, A M, Vona, B, Huang, K, Schmidt, J, Altmüller, J, Luppe, J, Platzer, K, Dörgeloh, B B, Busche, A, Biskup, S, Mendes, M I, Smith, D E C, Salomons, G S, Zibat, A, Bültmann, E, Nürnberg, P, Spielmann, M, Lemke, J R, Li, Y, Zenker, M, Varshney, G K, Hillen, H S, Kratz, C P & Wollnik, B 2022, ' WARS1 and SARS1 : Two tRNA synthetases implicated in autosomal recessive microcephaly ', Human Mutation, vol. 43, no. 10, pp. 1454-1471 . https://doi.org/10.1002/humu.24430
Aminoacylation of tRNA is a key step in protein biosynthesis, carried out by highly specific aminoacyl-tRNA synthetases (ARS). ARS have been implicated in autosomal dominant and autosomal recessive human disorders. Autosomal dominant variants in tryp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85935df54049d5375dcb05087f17d26d
https://hdl.handle.net/21.11116/0000-000B-2BDE-C21.11116/0000-000B-2BE0-8
https://hdl.handle.net/21.11116/0000-000B-2BDE-C21.11116/0000-000B-2BE0-8
Autor:
Joanne P. Young, Amanda R. Townsend, Nicola K. Poplawski, Jennifer E. Hardingham, Jinghua Feng, Eric Smith, Arne Zibat, Yun Li, Timothy J. Price, Gökhan Yigit, Christian Müller, Wendy Uylaki, Reger R. Mikaeel, Mehgan Horsnell, Bernd Wollnik, Yoko Tomita, Gonzalo Tapia Rico, Silke Kaulfuß
Publikováno v:
Genes, chromosomescancerREFERENCES. 61(2)
Colorectal cancer (CRC) incidence in young adults is rising. Identifying genetic risk factors is fundamental for the clinical management of patients and their families. This study aimed to identify clinically significant germline variants among young
Autor:
Undine Lippert, Arne Zibat, Michael P. Schön, Konrad Bork, Karin Wulff, David M. Ferrari, Bernd Wollnik
Publikováno v:
JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 18:215-224
Autor:
Karin Wulff, David M. Ferrari, Undine Lippert, Bernd Wollnik, Konrad Bork, Arne Zibat, Michael P. Schön
Publikováno v:
JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 18:215-223
BACKGROUND Hereditary angioedema (HAE) is a group of genetic diseases characterized by recurrent, painful and potentially lethal tissue swelling. The most common form results from mutations in the SERPING1 gene, leading to reduced function of complem