Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

Autor: Jiang Ren, Judith Bruns, Peter Lindemann, Kathrin Motzny, Ronald Kühne, Slim Chiha, Matthias M. Müller, Monika Beerbaum, Robert Opitz, Stephan Dohmen, Matthias Barone, Arne Soicke, Marco Tobias Klein, Dominik Albat, Peter Schmieder, Udo Heinemann, Hartmut Oschkinat, Yvette Roske, Marc Nazaré, Hans-Günther Schmalz, Peter ten Dijke, Rudolf Volkmer, Maarten van Dinther

Publikováno v: Proceedings of the National Academy of Sciences, 117(47), 29684-29690. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America

Significance Protein–protein interactions mediated by proline-rich motifs are involved in regulation of many important signaling cascades. These motifs belong to the most abundant recognition motifs in the eukaryotic genome and preferentially adopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3f020fdbbb67aa9a4b024f1290a866
https://hdl.handle.net/1887/3185199

Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation

Autor: Marco Tobias Klein, Slim Chiha, Robert Opitz, Arne Soicke, Matthias Barone, Hans-Günther Schmalz, Jörg-Martin Neudörfl, Cédric Reuter, Ronald Kühne, Stephan Dohmen

Publikováno v: Chemistry - A European Journal. 21:8464-8470

With the aim of developing polyproline type II helix (PPII) secondary-structure mimetics for the modulation of prolin-rich-mediated protein-protein interactions, the novel diproline mimetic ProM-2 was designed by bridging the two pyrrolidine rings of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706a50a8470c1195813f621aa2a94e9e
https://doi.org/10.1002/chem.201406493

Metal-Free Intramolecular Carbonyl-Olefin Metathesis of ortho-Prenylaryl Ketones

Autor: Jörg-Martin Neudörfl, Arne Soicke, Nikolay Slavov, Hans-Günther Schmalz

Publikováno v: Synlett. 2011:2487-2490

On treatment with boron trifluoride etherate as a Lewis acid, acetophenone and benzophenone derivatives bearing a prenyl (or a related) side chain in ortho-position were shown to undergo intramolecular carbonyl―olefin metathesis, in the absence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bda5a4e9b309a4f53497975ff2579e21
https://doi.org/10.1055/s-0030-1260320

ChemInform Abstract: Stereoselective Synthesis of Tricyclic Diproline Analogues that Mimic a PPII Helix: Structural Consequences of Ring-Size Variation

Autor: Ronald Kuehne, Joerg‐Martin Neudoerfl, Hans‐Guenther Schmalz, Arne Soicke, Matthias Winter, Nils Schloerer, Cédric Reuter

Publikováno v: ChemInform. 46

Synthons (VI) and (Xb) are prepared and used in the peptide coupling with proline derivative (XI).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db14983ddcf6d7f4b0393f1978410138
https://doi.org/10.1002/chin.201513273

4-(4,4,5,5-Tetramethyl-1,3,2-dioxoborolan-2-yl)-isoxazole

Autor: Juraj Velcicky, Hans-Günther Schmalz, Arne Soicke

Publikováno v: e-EROS Encyclopedia of Reagents for Organic Synthesis

[928664-98-6] C9H14BNO3 (MW: 195.11) InChI = 1S/C9H14BNO3/c1-8(2)9(3,4)14-10(13-8)7-5-11-12-6-7/h5-6H,1-4H3 InChIKey = LXCICYRNWIGDQA-UHFFFAOYSA-N (Suzuki coupling reagent, acetonitrile anion equivalent1, 2) Physical Data: mp 109–112 °C. Solubilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9185f289ee46abf12782ec99391a78f4
https://doi.org/10.1002/047084289x.rn01478