Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Arne SchÖN"'
Autor:
Bailey B. Banach, Sergei Pletnev, Adam S. Olia, Kai Xu, Baoshan Zhang, Reda Rawi, Tatsiana Bylund, Nicole A. Doria-Rose, Thuy Duong Nguyen, Ahmed S. Fahad, Myungjin Lee, Bob C. Lin, Tracy Liu, Mark K. Louder, Bharat Madan, Krisha McKee, Sijy O’Dell, Mallika Sastry, Arne Schön, Natalie Bui, Chen-Hsiang Shen, Jacy R. Wolfe, Gwo-Yu Chuang, John R. Mascola, Peter D. Kwong, Brandon J. DeKosky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The HIV-1 fusion peptide (FP) represents a promising vaccine target, but global FP sequence diversity among circulating strains has limited anti-FP antibodies to ~60% neutralization breadth. Here we evolve the FP-targeting antibody VRC34.01
Externí odkaz:
https://doaj.org/article/e636e8ff307e4e158f7f9667c39522e1
Autor:
Baoshan Zhang, Jason Gorman, Young D. Kwon, Amarendra Pegu, Cara W. Chao, Tracy Liu, Mangaiarkarasi Asokan, Michael F. Bender, Tatsiana Bylund, Leland Damron, Deepika Gollapudi, Paula Lei, Yile Li, Cuiping Liu, Mark K. Louder, Krisha McKee, Adam S. Olia, Reda Rawi, Arne Schön, Shuishu Wang, Eun Sung Yang, Yongping Yang, Kevin Carlton, Nicole A. Doria-Rose, Lawrence Shapiro, Michael S. Seaman, John R. Mascola, Peter D. Kwong
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody CAP256-VRC26.25 targets the second hypervariable region (V2) at the apex of the HIV envelope (Env) trimer with extraordinary neutralization potency, although less than optimal breadth. To improve breadth, we linked the light chain of
Externí odkaz:
https://doaj.org/article/bddbe9ec6f5b4b779bcbe4b49830cab8
Autor:
Manuela C. Aguirre-Botero, Lawrence T. Wang, Pauline Formaglio, Eduardo Aliprandini, Jean-Michel Thiberge, Arne Schön, Yevel Flores-Garcia, Shamika Mathis-Torres, Barbara J. Flynn, Lais da Silva Pereira, Yann Le Duff, Mathew Hurley, Adéla Nacer, Paul W. Bowyer, Fidel Zavala, Azza H. Idris, Joseph R. Francica, Robert A. Seder, Rogerio Amino
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112681- (2023)
Summary: Human monoclonal antibodies (hmAbs) targeting the Plasmodium falciparum circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for preventing malaria infection. However, their mechanisms of protection remain unclear.
Externí odkaz:
https://doaj.org/article/0e7fe2937927407cbebd3d4c244d9741
Autor:
Raffaello Verardi, Lisa C. Lindesmith, Yaroslav Tsybovsky, Jason Gorman, Gwo-Yu Chuang, Caitlin E. Edwards, Paul D. Brewer-Jensen, Michael L. Mallory, Li Ou, Arne Schön, Wei Shi, Ena S. Tully, George Georgiou, Ralph S. Baric, Peter D. Kwong
Publikováno v:
npj Vaccines, Vol 5, Iss 1, Pp 1-10 (2020)
Abstract Human noroviruses are non-enveloped, single-strand RNA viruses that cause pandemic outbreaks of acute gastroenteritis. A bivalent vaccine containing GI.1 and GII.4 virus-like particles (VLPs) has been shown to be safe and highly immunogenic,
Externí odkaz:
https://doaj.org/article/291f486fe191490c902890335db78af5
Autor:
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-19 (2020)
Abstract The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that esta
Externí odkaz:
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
Lawrence T Wang, Lais S Pereira, Patience K Kiyuka, Arne Schön, Neville K Kisalu, Rachel Vistein, Marlon Dillon, Brian G Bonilla, Alvaro Molina-Cruz, Carolina Barillas-Mury, Joshua Tan, Azza H Idris, Joseph R Francica, Robert A Seder
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010133 (2021)
Combinations of monoclonal antibodies (mAbs) against different epitopes on the same antigen synergistically neutralize many viruses. However, there are limited studies assessing whether combining human mAbs against distinct regions of the Plasmodium
Externí odkaz:
https://doaj.org/article/d385b3ce72a7496ba9242f6f5b20828b
Autor:
Neville K. Kisalu, Lais D. Pereira, Keenan Ernste, Yevel Flores-Garcia, Azza H. Idris, Mangaiarkarasi Asokan, Marlon Dillon, Scott MacDonald, Wei Shi, Xuejun Chen, Amarendra Pegu, Arne Schön, Fidel Zavala, Alejandro B. Balazs, Joseph R. Francica, Robert A. Seder
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
CIS43 is a potent neutralizing human mAb that targets a highly conserved “junctional” epitope in the Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP). Enhancing the durability of CIS43 in vivo will be important for clinical translation
Externí odkaz:
https://doaj.org/article/ec22f87b3a434413a25e71b29c3ef1c2
Autor:
Yen-Ting Lai, Tao Wang, Sijy O’Dell, Mark K. Louder, Arne Schön, Crystal S. F. Cheung, Gwo-Yu Chuang, Aliaksandr Druz, Bob Lin, Krisha McKee, Dongjun Peng, Yongping Yang, Baoshan Zhang, Alon Herschhorn, Joseph Sodroski, Robert T. Bailer, Nicole A. Doria-Rose, John R. Mascola, David R. Langley, Peter D. Kwong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Temsavir, a compound that inhibits HIV entry by binding envelope (Env), is currently in clinical development. Here, Lai et al. identify a more than 10-fold improved compound and, using lattice engineering, obtain crystal structures that give insights
Externí odkaz:
https://doaj.org/article/8c1780f80cef41df909afde553e1a2ab
Autor:
Alon Herschhorn, Christopher Gu, Francesca Moraca, Xiaochu Ma, Mark Farrell, Amos B. Smith, Marie Pancera, Peter D. Kwong, Arne Schön, Ernesto Freire, Cameron Abrams, Scott C. Blanchard, Walther Mothes, Joseph G. Sodroski
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Binding of viral envelope glycoproteins (Env) to the host cell CD4 receptor mediates HIV-1 entry. Here, the authors develop compounds that inhibit the CD4-induced conformational changes in Env and show that the gp120 β20-β21 element is a key regula
Externí odkaz:
https://doaj.org/article/b36161e14e3f46feaa6eadd812d25c74
Autor:
Alon Herschhorn, Christopher Gu, Francesca Moraca, Xiaochu Ma, Mark Farrell, Amos B. Smith, Marie Pancera, Peter D. Kwong, Arne Schön, Ernesto Freire, Cameron Abrams, Scott C. Blanchard, Walther Mothes, Joseph G. Sodroski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The original version of this Article contained an error in the spelling of the author Amos B. Smith, III, which was incorrectly given as Amos B. SmithIII. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/674c8bbdf17a40eb8d6bf661351a14be