High‐fat diet and oral infection induced type 2 diabetes and obesity development under different genetic backgrounds

Autor: Iqbal M. Lone, Nadav Ben Nun, Aya Ghnaim, Arne S. Schaefer, Yael Houri‐Haddad, Fuad A. Iraqi

Publikováno v: Animal Models and Experimental Medicine, Vol 6, Iss 2, Pp 131-145 (2023)

Abstract Background Type 2 diabetes (T2D) is an adult‐onset and obese form of diabetes caused by an interplay between genetic, epigenetic, and environmental components. Here, we have assessed a cohort of 11 genetically different collaborative cross

Externí odkaz: https://doaj.org/article/ec5734a9df444077a080ea712e4e38a9

Qtlizer: comprehensive QTL annotation of GWAS results

Autor: Matthias Munz, Inken Wohlers, Eric Simon, Tobias Reinberger, Hauke Busch, Arne S. Schaefer, Jeanette Erdmann

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)

Abstract Exploration of genetic variant-to-gene relationships by quantitative trait loci such as expression QTLs is a frequently used tool in genome-wide association studies. However, the wide range of public QTL databases and the lack of batch annot

Externí odkaz: https://doaj.org/article/c15af683c6d44f738b2725a1b8a69822

GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation

Autor: Steven Offenbacher, Yizu Jiao, Steven J. Kim, Julie Marchesan, Kevin L. Moss, Li Jing, Kimon Divaris, Sompop Bencharit, Cary S. Agler, Thiago Morelli, Shaoping Zhang, Lu Sun, William T. Seaman, Dale Cowley, Silvana P. Barros, James D. Beck, Matthias Munz, Arne S. Schaefer, Kari E. North

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

IL-1β in gingival crevicular fluid (GCF) is a marker of inflammation in periodontal disease. Here, Offenbacher et al. identify genetic variants in the IL37 locus associated with GCF-IL-1β and show that the IL-1β-increasing allele at rs3811046 lead

Externí odkaz: https://doaj.org/article/c09756d6c83548c2b068a9c266188a12

Case‐only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD‐2353F22 .1 implying the importance of periodontal wound healing for disease aetiology

Autor: Ricarda Müller, Sandra Freitag‐Wolf, January Weiner, Avneesh Chopra, Tugba Top, Henrik Dommisch, Arne S. Schaefer

Publikováno v: Journal of Clinical Periodontology. 50:90-101

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e6ee47b5198dcf69a9ddc3910996b31
https://doi.org/10.1111/jcpe.13712

Sex-specific genetic factors affect the risk of early-onset periodontitis in Europeans

Autor: Christian Graetz, Bruno G. Loos, Corinna Bruckmann, Yvonne Jockel-Schneider, Andre Franke, Ingmar Staufenbiel, Sandra Freitag-Wolf, Arne S. Schaefer, Olaf Junge, Matthias Munz, Søren Jepsen, Henrik Dommisch, Wolfgang Lieb

Publikováno v: Freitag-Wolf, S, Munz, M, Junge, O, Graetz, C, Jockel-Schneider, Y, Staufenbiel, I, Bruckmann, C, Lieb, W, Franke, A, Loos, B G, Jepsen, S, Dommisch, H & Schaefer, A S 2021, ' Sex-specific genetic factors affect the risk of early-onset periodontitis in Europeans ', Journal of Clinical Periodontology, vol. 48, no. 11, pp. 1404-1413 . https://doi.org/10.1111/jcpe.13538
Journal of Clinical Periodontology, 48(11), 1404-1413. Blackwell Munksgaard

© 2021 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.Aims: Various studies have reported that young European women are more likely to develop early-onset periodontitis compared to men. A potential explanation for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5014a5880a612ca5fada7b518777cc
https://hdl.handle.net/1871.1/0d53f930-65b7-4c57-b33d-026becad158b