Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Arne N Akbar"'
Autor:
Cristina Tommasi, Ohad Yogev, Michael B. Yee, Andriani Drousioti, Meleri Jones, Alice Ring, Manuraj Singh, Inga Dry, Oscar Atkins, Aishath S. Naeem, Nisha Kriplani, Arne N. Akbar, Jürgen G. Haas, Edel A. O’Toole, Paul R. Kinchington, Judith Breuer
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-11 (2024)
Abstract Varicella-zoster virus (VZV) is the etiological agent of chickenpox and shingles, diseases characterised by epidermal virus replication in skin and mucosa and the formation of blisters. We have previously shown that VZV infection has a profo
Externí odkaz:
https://doaj.org/article/09112decde4b4fc2923182d25e256520
Autor:
Luciana Polaco Covre, Carlos Henrique Fantecelle, Renan Garcia de Moura, Paola Oliveira Lopes, Isabela Valim Sarmento, Celio Geraldo Freire-de-Lima, Debora Decote-Ricardo, Herbert Leonel de Matos Guedes, Alessandra Marcia da Fonsceca-Martins, Lucas Pedreira de Carvalho, Edgar Marcelino de Carvalho, David M. Mosser, Aloisio Falqueto, Arne N. Akbar, Daniel Claudio Oliveira Gomes
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cytotoxic activity is a hallmark of the immunopathogenesis in human cutaneous leishmaniasis (CL). In this study, we identified accumulation of CD4+ granzyme B producing T cells with increased cytotoxic capacity in CL lesions. These cells showed enhan
Externí odkaz:
https://doaj.org/article/62e70576cb3d4ad59dcb11eebedd7965
Autor:
Karen T. Feehan, Hannah E. Bridgewater, Jan Stenkiewicz-Witeska, Roel P. H. De Maeyer, John Ferguson, Matthias Mack, Jeremy Brown, Giuseppe Ercoli, Connar M. Mawer, Arne N. Akbar, James R. W. Glanville, Parinaaz Jalali, Olivia V. Bracken, Anna Nicolaou, Alexandra C. Kendall, Michelle A. Sugimoto, Derek W. Gilroy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Resolving inflammation is thought to return the affected tissue back to homoeostasis but recent evidence supports a non-linear model of resolution involving a phase of prolonged immune activity. Here we show that within days following resolu
Externí odkaz:
https://doaj.org/article/2c3602528dd144b09810421a90f86c86
Autor:
David R. Pearce, Ayse U. Akarca, Roel P. H. De Maeyer, Emily Kostina, Ariana Huebner, Monica Sivakumar, Takahiro Karasaki, Kavina Shah, Sam M. Janes, Nicholas McGranahan, Venkat Reddy, Arne N. Akbar, David A. Moore, Teresa Marafioti, Charles Swanton, Robert E. Hynds
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundPatient-derived xenograft (PDX) models involve the engraftment of tumour tissue in immunocompromised mice and represent an important pre-clinical oncology research method. A limitation of non-small cell lung cancer (NSCLC) PDX model derivat
Externí odkaz:
https://doaj.org/article/cae9afdbf4674ceea00f1d3863b707db
Autor:
Lauren A. Callender, Johannes Schroth, Elizabeth C. Carroll, Conor Garrod-Ketchley, Lisa E. L. Romano, Eleanor Hendy, Audrey Kelly, Paul Lavender, Arne N. Akbar, J. Paul Chapple, Sian M. Henson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and b
Externí odkaz:
https://doaj.org/article/e3707e322df34c44b2251936c03964a1
Autor:
Branca I. Pereira, Oliver P. Devine, Milica Vukmanovic-Stejic, Emma S. Chambers, Priya Subramanian, Neil Patel, Alex Virasami, Neil J. Sebire, Veronica Kinsler, Alexis Valdovinos, Claude Jourdan LeSaux, João F. Passos, Antony Antoniou, Malcom H. A. Rustin, Judith Campisi, Arne N. Akbar
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell acti
Externí odkaz:
https://doaj.org/article/a849def66981451db25ae5092d6b7804
Autor:
Weili Xu, Gianni Monaco, Eleanor Huijin Wong, Wilson Lek Wen Tan, Hassen Kared, Yannick Simoni, Shu Wen Tan, Wilson Zhi Yong How, Crystal Tze Ying Tan, Bernett Teck Kwong Lee, Daniel Carbajo, Srinivasan K.G., Ivy Chay Huang Low, Esther Wing Hei Mok, Shihui Foo, Josephine Lum, Hong Liang Tey, Wee Ping Tan, Michael Poidinger, Evan Newell, Tze Pin Ng, Roger Foo, Arne N. Akbar, Tamas Fülöp, Anis Larbi
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 44-58 (2019)
Background: Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance. We investigated the impact of aging on γδ T
Externí odkaz:
https://doaj.org/article/1de8ee1204604eb2a6fbd69c78a8cfae
Autor:
Renan Garcia de Moura, Luciana Polaco Covre, Carlos Henrique Fantecelle, Vitor Alejandro Torres Gajardo, Carla Baroni Cunha, Lorenzzo Lyrio Stringari, Ashton Trey Belew, Camila Batista Daniel, Sandra Ventorin Von Zeidler, Carlos Eduardo Tadokoro, Herbert Leonel de Matos Guedes, Raphael Lubiana Zanotti, David Mosser, Aloisio Falqueto, Arne N. Akbar, Daniel Claudio Oliveira Gomes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Patients infected by Leishmania braziliensis develop debilitating skin lesions. The role of inhibitory checkpoint receptors (ICRs) that induce T cell exhaustion during this disease is not known. Transcriptional profiling identified increased expressi
Externí odkaz:
https://doaj.org/article/d7475f9b3d034bcb940bc04b036e221c
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
One of the most appreciated consequences of immunosenescence is an impaired response to vaccines with advanced age. While most studies report impaired antibody responses in older adults as a correlate of vaccine efficacy, it is now widely appreciated
Externí odkaz:
https://doaj.org/article/207b039953af42a6b378cb320604dfe6
Autor:
Luciana P. Covre, Régia F. Martins, Oliver P. Devine, Emma S. Chambers, Milica Vukmanovic-Stejic, Juliana A. Silva, Reynaldo Dietze, Rodrigo R. Rodrigues, Herbert L. de Matos Guedes, Aloísio Falqueto, Arne N. Akbar, Daniel C. O. Gomes
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Leishmania (Viannia) braziliensis induces American tegumentary leishmaniasis that ranges in severity from the milder form, cutaneous (CL) to severe disseminated cutaneous leishmaniasis. Patients with CL develop a cell-mediated Th1 immune response acc
Externí odkaz:
https://doaj.org/article/1f35bdcc381541f580c4cd9e8b9f7e2f