Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Arne Martens"'
Autor:
Karel F. A. Van Damme, Pieter Hertens, Arne Martens, Elisabeth Gilis, Dario Priem, Inge Bruggeman, Amelie Fossoul, Jozefien Declercq, Helena Aegerter, Andy Wullaert, Tino Hochepied, Esther Hoste, Lieselotte Vande Walle, Mohamed Lamkanfi, Savvas N. Savvides, Dirk Elewaut, Bart N. Lambrecht, Geert van Loo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthrit
Externí odkaz:
https://doaj.org/article/0bf2e4c99bae45e2afbc4924a4035aa2
Autor:
Lien Verboom, Christopher J. Anderson, Maude Jans, Ioanna Petta, Gillian Blancke, Arne Martens, Mozes Sze, Tino Hochepied, Kodi S. Ravichandran, Lars Vereecke, Geert van Loo
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-13 (2023)
Abstract The intestinal epithelium is a single cell layer that is constantly renewed and acts as a physical barrier that separates intestinal microbiota from underlying tissues. In inflammatory bowel disease (IBD) in humans, as well as in experimenta
Externí odkaz:
https://doaj.org/article/7eadb0df90114b9c9cc7180ab08eeb46
Autor:
Esther Hoste, Kim Lecomte, Karl Annusver, Niels Vandamme, Jana Roels, Sophia Maschalidi, Lien Verboom, Hanna-Kaisa Vikkula, Mozes Sze, Lisette Van Hove, Kevin Verstaen, Arne Martens, Tino Hochepied, Yvan Saeys, Kodi Ravichandran, Maria Kasper, Geert van Loo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of
Externí odkaz:
https://doaj.org/article/8b051a56d99b49d783afe85a0b01f20a
Autor:
Leen Catrysse, Bastiaan Maes, Parul Mehrotra, Arne Martens, Esther Hoste, Liesbet Martens, Christian Maueröder, Anneleen Remmerie, Anna Bujko, Karolina Slowicka, Mozes Sze, Hanna Vikkula, Bart Ghesquière, Charlotte L. Scott, Yvan Saeys, Bart van de Sluis, Kodi Ravichandran, Sophie Janssens, Geert van Loo
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109748- (2021)
Summary: Obesity-induced inflammation is a major driving force in the development of insulin resistance, type 2 diabetes (T2D), and related metabolic disorders. During obesity, macrophages accumulate in the visceral adipose tissue, creating a low-gra
Externí odkaz:
https://doaj.org/article/8fd7d230be304c529b1a2ae294191f7d
Autor:
Karolina Slowicka, Inmaculada Serramito-Gómez, Emilio Boada-Romero, Arne Martens, Mozes Sze, Ioanna Petta, Hanna K. Vikkula, Riet De Rycke, Eef Parthoens, Saskia Lippens, Savvas N. Savvides, Andy Wullaert, Lars Vereecke, Felipe X. Pimentel-Muiños, Geert van Loo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective prot
Externí odkaz:
https://doaj.org/article/66f4ba80a7fd4950b7b10906aec986dc
Autor:
Lien Verboom, Arne Martens, Dario Priem, Esther Hoste, Mozes Sze, Hanna Vikkula, Lisette Van Hove, Sofie Voet, Jana Roels, Jonathan Maelfait, Laura Bongiovanni, Alain de Bruin, Charlotte L. Scott, Yvan Saeys, Manolis Pasparakis, Mathieu J.M. Bertrand, Geert van Loo
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2237-2247.e6 (2020)
Summary: Inflammatory signaling pathways are tightly regulated to avoid chronic inflammation and the development of disease. OTULIN is a deubiquitinating enzyme that controls inflammation by cleaving linear ubiquitin chains generated by the linear ub
Externí odkaz:
https://doaj.org/article/1511e219df8c4f228d716b7cc3be84c8
Autor:
Sofie Voet, Conor Mc Guire, Nora Hagemeyer, Arne Martens, Anna Schroeder, Peter Wieghofer, Carmen Daems, Ori Staszewski, Lieselotte Vande Walle, Marta Joana Costa Jordao, Mozes Sze, Hanna-Kaisa Vikkula, Delphine Demeestere, Griet Van Imschoot, Charlotte L. Scott, Esther Hoste, Amanda Gonçalves, Martin Guilliams, Saskia Lippens, Claude Libert, Roos E. Vandenbroucke, Ki-Wook Kim, Steffen Jung, Zsuzsanna Callaerts-Vegh, Patrick Callaerts, Joris de Wit, Mohamed Lamkanfi, Marco Prinz, Geert van Loo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central
Externí odkaz:
https://doaj.org/article/3142b0c70aa74f90b3c6f5b5f17ce066
Autor:
Arne Martens, Pieter Hertens, Dario Priem, Vagelis Rinotas, Theodore Meletakos, Meropi Gennadi, Lisette Van Hove, Els Louagie, Julie Coudenys, Amélie De Muynck, Djoere Gaublomme, Mozes Sze, Jolanda van Hengel, Leen Catrysse, Esther Hoste, Jeffrey D Zajac, Rachel A Davey, Luc Van Hoorebeke, Tino Hochepied, Mathieu J M Bertrand, Marietta Armaka, Dirk Elewaut, Geert van Loo
Publikováno v:
EMBO REPORTS
The anti-inflammatory protein A20 serves as a critical brake on NF-kappa B signaling and NF-kappa B-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been associated with several inflammatory disorders, including r
Autor:
Yoshitaka Shirasaki, Bernhard Holzmann, Sotaro Uemura, Marietta Armaka, Manolis Pasparakis, Geert van Loo, Apostolos Polykratis, Masayuki Miura, Arne Martens, Mai Yamagishi, George Kollias, Yoshifumi Yamaguchi, Remzi Onur Eren
Publikováno v:
Nature Cell Biology
Deficiency in the deubiquitinating enzyme A20 causes severe inflammation in mice, and impaired A20 function is associated with human inflammatory diseases. A20 has been implicated in negatively regulating NF-κB signalling, cell death and inflammasom
Autor:
Karl Annusver, Tino Hochepied, Niels Vandamme, Lisette Van Hove, Lien Verboom, Kevin Verstaen, Geert van Loo, Yvan Saeys, Jana Roels, Mozes Sze, Hanna-Kaisa Vikkula, Sophia Maschalidi, Esther Hoste, Arne Martens, Kim Lecomte, Kodi S. Ravichandran, Maria Kasper
Publikováno v:
NATURE COMMUNICATIONS
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
OTULIN is a deubiquitinase that specifically cleaves linear ubiquitin chains. Here we demonstrate that the ablation of Otulin selectively in keratinocytes causes inflammatory skin lesions that develop into verrucous carcinomas. Genetic deletion of Tn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f681c437ac2ee2689c9eba5ab71f433d
https://biblio.ugent.be/publication/8728696
https://biblio.ugent.be/publication/8728696