Zobrazeno 1 - 10 of 38 pro vyhledávání: '"Arne Kutzner"'
1
Akademický článek
MSV: a modular structural variant caller that reveals nested and complex rearrangements by unifying breakends inferred directly from reads
Autor: Markus Schmidt, Arne Kutzner
Publikováno v: Genome Biology, Vol 24, Iss 1, Pp 1-27 (2023)
Abstract Structural variant (SV) calling belongs to the standard tools of modern bioinformatics for identifying and describing alterations in genomes. Initially, this work presents several complex genomic rearrangements that reveal conceptual ambigui
Externí odkaz: https://doaj.org/article/70781a912727432d9b074e6211c249e8
Zobrazit plný text záznamu
3
Akademický článek
A performant bridge between fixed-size and variable-size seeding
Autor: Arne Kutzner, Pok-Son Kim, Markus Schmidt
Publikováno v: BMC Bioinformatics, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background Seeding is usually the initial step of high-throughput sequence aligners. Two popular seeding strategies are fixed-size seeding (k-mers, minimizers) and variable-size seeding (MEMs, SMEMs, maximal spanning seeds). The former strat
Externí odkaz: https://doaj.org/article/b5594adbb3764b90ab7cba04d0647d5d
Zobrazit plný text záznamu
4
Akademický článek
Accurate high throughput alignment via line sweep-based seed processing
Autor: Markus Schmidt, Klaus Heese, Arne Kutzner
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Alignment is an important stage in the analysis of sequencing data. Here, the authors present a fast and accurate alignment approach suitable for long and short reads, and introduce two line sweep-based techniques which can replace the often-used cha
Externí odkaz: https://doaj.org/article/fa27a9d32d6e484088cd6883e0fc34c1
Zobrazit plný text záznamu
5
Akademický článek
Antibacterial, Antifungal, and Antioxidant Activities of Silver Nanoparticles Biosynthesized from Bauhinia tomentosa Linn
Autor: Senthil Renganathan, Sugunakala Subramaniyan, Nivetha Karunanithi, Preethi Vasanthakumar, Arne Kutzner, Pok-Son Kim, Klaus Heese
Publikováno v: Antioxidants, Vol 10, Iss 12, p 1959 (2021)
The biogenic synthesis of silver nanoparticles (AgNPs) has a wide range of applications in the pharmaceutical industry. Here, we synthesized AgNPs using the aqueous flower extract of Bauhinia tomentosa Linn. Formation of AgNPs was observed using ultr
Externí odkaz: https://doaj.org/article/dce25b5d8fb848fe93478474ee636667
Zobrazit plný text záznamu
6
Phytochemical Profiling in Conjunction with In Vitro and In Silico Studies to Identify Human α-Amylase Inhibitors in Leucaena leucocephala (Lam.) De Wit for the Treatment of Diabetes Mellitus
Autor: Arne Kutzner, Pok-Son Kim, Senthil Renganathan, Klaus Heese, Usha Singaravelu, Preethi Vasanthakumar, Sakthivel Manokaran
Publikováno v: ACS Omega
ACS Omega, Vol 6, Iss 29, Pp 19045-19057 (2021)
Bioactive constituents from natural sources are of great interest as alternatives to synthetic compounds for the treatment of various diseases, including diabetes mellitus. In the present study, phytochemicals present in Leucaena leucocephala (Lam.)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccf1a94274a3ddfc4a6069d375aef78
http://europepmc.org/articles/PMC8320072
Zobrazit plný text záznamu
7
Identification of a Chemotherapeutic Lead Molecule for the Potential Disruption of the FAM72A-UNG2 Interaction to Interfere with Genome Stability, Centromere Formation, and Genome Editing
Autor: Senthil Renganathan, Arne Kutzner, Klaus Heese, Subrata Pramanik, Pok-Son Kim, Rajasekaran Ekambaram
Publikováno v: Cancers, Vol 13, Iss 5870, p 5870 (2021)
Cancers
Cancers; Volume 13; Issue 22; Pages: 5870
Simple Summary Pivotal factors that contribute to tumorigenesis were subjected to analysis by molecular modeling. In particular, the FAM72A-UNG2 protein–protein interaction was modeled to predict a potential solution for the treatment of cancer. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065be22012c08f046d2bd88461602f97
https://www.mdpi.com/2072-6694/13/22/5870
Zobrazit plný text záznamu
8
A Novel Divergent Gene Transcription Paradigm—the Decisive, Brain-Specific, Neural |-Srgap2–Fam72a-| Master Gene Paradigm
Autor: Arne Kutzner, Klaus Heese, Nguyen Thi Thanh Ho
Publikováno v: Molecular Neurobiology. 56:5891-5899
Brain development and repair largely depend on neural stem cells (NSCs). Here, we suggest that two genes, i.e., Srgap2 (SLIT-ROBO Rho GTPase-activating protein 2) and Fam72a (family with sequence similarity to 72, member A), constitute a single, NSC-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3f565b54b36f5a8314e29c90af196a
https://doi.org/10.1007/s12035-019-1486-5
Zobrazit plný text záznamu
9
Establishing a human adrenocortical carcinoma (ACC)-specific gene mutation signature
Autor: Arne Kutzner, Klaus Heese, Chinmay Satish Rahane
Publikováno v: Cancer Genetics. 230:1-12
Adrenocortical carcinoma (ACC) is a rare and aggressive tumor whose molecular signaling pathways are not fully understood. Using an in-silico clinical data analysis approach we retrieved human gene mutation data from the highly reputed Cancer Genome
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9601978fb64085479299c8e94cc5109d
https://doi.org/10.1016/j.cancergen.2018.10.005
Zobrazit plný text záznamu
10
State-of-the-art structural variant calling: What went conceptually wrong and how to fix it?
Autor: Arne Kutzner, Markus Schmidt
Structural variant (SV) calling belongs to the standard tools of modern bioinformatics for identifying and describing alterations in genomes. Initially, this work presents several complex genomic rearrangements that reveal conceptual ambiguities inhe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7525b4913447d25155dd42730135ab79
https://doi.org/10.1101/2021.01.12.426317
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje