Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Arne Krack"'
Autor:
Armin Hofmeister, Kerstin Jahn-Hofmann, Bodo Brunner, Mike Helms, Christiane Metz-Weidmann, Arne Krack, Michael Kurz, Christoph Heubel, Sabine Scheidler
Publikováno v:
Journal of Medicinal Chemistry. 65:13736-13752
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d15651602661ac7766e15b8619f3464
https://doi.org/10.1021/acs.jmedchem.2c00873
https://doi.org/10.1021/acs.jmedchem.2c00873
Autor:
Armin, Hofmeister, Kerstin, Jahn-Hofmann, Bodo, Brunner, Mike, Helms, Christiane, Metz-Weidmann, Arne, Krack, Michael, Kurz, Christoph, Heubel, Sabine, Scheidler
Publikováno v:
Journal of medicinal chemistry. 65(20)
To expand the applicability of recently developed dioxane- and morpholino-based nucleotide analogues, their seed region destabilizing properties in small interfering RNAs (siRNAs) were investigated in order to improve potential off-target profiles. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5eba99c0ac654d0cc40dd0f969d39ae8
https://pubmed.ncbi.nlm.nih.gov/36223135
https://pubmed.ncbi.nlm.nih.gov/36223135
Autor:
Christiane Metz-Weidmann, Elsa Pflimlin, Kerstin Jahn-Hofmann, Ziyu Li, Bodo Brunner, Sabine Scheidler, Armin Hofmeister, Merle M Weitzenberg, Arne Krack, Mike W Helms, Oliver Plettenburg, Michael Kurz
Publikováno v:
Journal of Medicinal Chemistry. 64:6838-6855
A morpholine-based nucleotide analog was developed as a building block for hepatic siRNA targeting and stabilization. Attachment of an asialoglycoprotein-binding GalNAc ligand at the morpholine nitrogen was realized with different linkers. The obtain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da575d8ed74811c57899552ba2f2ae2c
https://doi.org/10.1021/acs.jmedchem.1c00144
https://doi.org/10.1021/acs.jmedchem.1c00144
Autor:
Kerstin Jahn-Hofmann, Sabine Scheidler, Armin Hofmeister, Arne Krack, Michael Kurz, Armin Müller
Publikováno v:
ChemBioChem. 22:1072-1078
A novel class of nucleotide analogues with a dioxane ring as central scaffold has been developed. Synthetic routes in two diastereomeric series were realized, and the final thymidine analogues were synthesized with common functionalities for the auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5faae7eee175f7786f73875f4b5a79
https://doi.org/10.1002/cbic.202000693
https://doi.org/10.1002/cbic.202000693