Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Arne Knörck"'
Autor:
Arne Knörck, Gertrud Schäfer, Dalia Alansary, Josephine Richter, Lorenz Thurner, Markus Hoth, Eva C. Schwarz
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunological memory is important to protect humans against recurring diseases. Memory CD8+ T cells are required for quick expansion into effector cells but also provide immediate cytotoxicity against their targets. Whereas many functions of the two
Externí odkaz:
https://doaj.org/article/67602278fa024d9f9bc5a966a6ecbafc
Autor:
Wenjuan Yang, Andreas Denger, Caroline Diener, Frederic Küppers, Leticia Soriano-Baguet, Gertrud Schäfer, Archana K. Yanamandra, Renping Zhao, Arne Knörck, Eva C. Schwarz, Martin Hart, Frank Lammert, Leticia Prates Roma, Dirk Brenner, Grigorios Christidis, Volkhard Helms, Eckart Meese, Markus Hoth, Bin Qu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
TNF-related apoptosis inducing ligand (TRAIL) is expressed on cytotoxic T lymphocytes (CTLs) and TRAIL is linked to progression of diabetes. However, the impact of high glucose on TRAIL expression and its related killing function in CTLs still remain
Externí odkaz:
https://doaj.org/article/41dfb74dc93e4233acaa18be90003c70
Autor:
Martin Fischer, Inga Grundke, Sindy Sohr, Marianne Quaas, Saskia Hoffmann, Arne Knörck, Catalina Gumhold, Karen Rother
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63187 (2013)
The microtubule-dependent molecular motor KIF23 (Kinesin family member 23) is one of two components of the centralspindlin complex assembled during late stages of mitosis. Formation of this complex is known as an essential step for cytokinesis. Here,
Externí odkaz:
https://doaj.org/article/666b4b8b77c64e5caf3efef49c229974
Autor:
Kim S. Friedmann, Lea Kaschek, Arne Knörck, Sabrina Cappello, Niklas Lünsmann, Nadja Küchler, Cora Hoxha, Gertrud Schäfer, Sandra Iden, Ivan Bogeski, Carsten Kummerow, Eva C. Schwarz, Markus Hoth
Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells recognize and eliminate cancer cells. However, immune evasion, downregulation of immune function by the tumour microenvironment and resistance of cancer cells are major problems. Although CT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6badd93022eca28c285a2554193944
Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice
Autor:
Elmar Krause, Gertrud Schwär, Maik Konrad, Annette Lis, Romy Steiner, Adrian Angenendt, Arne Knörck
Publikováno v:
Aging. 12:3266-3286
Ca2+ is a crucial second messenger for proper T cell function. Considering the relevance of Ca2+ signals for T cell functionality it is surprising that no mechanistic insights into T cell Ca2+ signals from elderly individuals are reported. The main C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02ed705154d3eae5753b476528a20d86
https://doi.org/10.18632/aging.102809
https://doi.org/10.18632/aging.102809
Autor:
Gertrud Schäfer, Volkhard Helms, Markus Hoth, Grigorios Christidis, Arne Knörck, Archana K. Yanamandra, Eva C. Schwarz, Caroline Diener, Leticia Soriano-Baguet, Eckart Meese, Leticia Prates Roma, Frank Lammert, Martin Hart, Bin Qu, Wenjuan Yang, Frederic Küppers, Dirk Brenner, Renping Zhao, Andreas Denger
Cytotoxic T lymphocytes (CTLs) are involved in development of diabetes. However, the impact of excessive glucose on CTL-mediated antigen-independent killing remains elusive. Here, we report that TNF-related apoptosis inducing ligand (TRAIL) is substa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8135e253f44cc3ba6f3a7bb59cdeea4b
https://doi.org/10.1101/2021.08.04.455060
https://doi.org/10.1101/2021.08.04.455060
Publikováno v:
Seminars in celldevelopmental biology. 115
Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells are required for host defense. They destroy malignant target cells like cancer cells. Among metal cations, Ca2+ plays a prescinded role for CTL and NK cytotoxicity as it is the only cation u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857bdb3f5dacbeb4556a713a37aa0940
https://pubmed.ncbi.nlm.nih.gov/33358089
https://pubmed.ncbi.nlm.nih.gov/33358089
Autor:
Markus Hoth, Ivan Bogeski, Sandra Iden, Carsten Kummerow, Gertrud Schwär, Sabrina Cappello, Arne Knörck, Kim S. Friedmann, Cora Hoxha, Eva C. Schwarz
CTL and NK cells recognize and eliminate cancer cells. However, immune evasion, down regulation of immune function by the tumor microenvironment, or resistance of cancer cells are a major problem. While CTL and NK cells are both important to eliminat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8984e6450bc46997c4b05c72d8c823b0
https://doi.org/10.1101/2020.06.14.150672
https://doi.org/10.1101/2020.06.14.150672
Autor:
Xianjun Yu, Shunrong Ji, Liang Liu, Volkhard Helms, Gertrud Schwär, Xiao Zhou, Mohamed Hamed, Bin Qu, Renping Zhao, Chen Liu, Rouven Schoppmeyer, Arne Knörck, Eva C. Schwarz, Yan Zhou, Markus Hoth, Jiang Long, He Cheng
Publikováno v:
European Journal of Immunology. 47:1562-1572
The actin-binding protein profilin1 (PFN1) plays a central role in actin dynamics, which is essential for cytotoxic T lymphocyte (CTL) functions. The functional role of PFN1 in CTLs, however still remains elusive. Here, we identify PFN1 as the only m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7423962f69be90a36c0cd93d6e8b8b5f
https://doi.org/10.1002/eji.201747124
https://doi.org/10.1002/eji.201747124
Autor:
Adrian, Angenendt, Romy, Steiner, Arne, Knörck, Gertrud, Schwär, Maik, Konrad, Elmar, Krause, Annette, Lis
Publikováno v:
Aging (Albany NY)
Ca2+ is a crucial second messenger for proper T cell function. Considering the relevance of Ca2+ signals for T cell functionality it is surprising that no mechanistic insights into T cell Ca2+ signals from elderly individuals are reported. The main C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50636593a029980c151d7f2a66bd7cc2
https://pubmed.ncbi.nlm.nih.gov/32062611
https://pubmed.ncbi.nlm.nih.gov/32062611