Privacy-preserving dataset combination and Lasso regression for healthcare predictions

Autor: Marie Beth van Egmond, Gabriele Spini, Onno van der Galien, Arne IJpma, Thijs Veugen, Wessel Kraaij, Alex Sangers, Thomas Rooijakkers, Peter Langenkamp, Bart Kamphorst, Natasja van de L’Isle, Milena Kooij-Janic

Publikováno v: BMC Medical Informatics and Decision Making, Vol 21, Iss 1, Pp 1-16 (2021)

Abstract Background Recent developments in machine learning have shown its potential impact for clinical use such as risk prediction, prognosis, and treatment selection. However, relevant data are often scattered across different stakeholders and the

Externí odkaz: https://doaj.org/article/8b263a8d1f5744b1a5839a1725efb851

Molecular phenotyping and functional assessment of smooth muscle-like cells with pathogenic variants in aneurysm genes ACTA2, MYH11, SMAD3 and FBN1

Autor: Nathalie P. de Wagenaar, Timo L.M. ten Hagen, Danielle Majoor-Krakauer, Ingrid van der Pluijm, Arne IJpma, Joyce Burger, Hui Liu, Nicole van Vliet, Jeroen Essers, Alessandra Maugeri, Kak K. Yeung, Natalija Bogunovic, Dimitra Micha, Hence J.M. Verhagen

Publikováno v: Burger, J, Bogunovic, N, de Wagenaar, N P, Liu, H, van Vliet, N, IJpma, A, Maugeri, A, Micha, D, Verhagen, H J M, Ten Hagen, T L M, Majoor-Krakauer, D, van der Pluijm, I, Essers, J & Yeung, K K 2021, ' Molecular phenotyping and functional assessment of smooth muscle-like cells with pathogenic variants in aneurysm genes ACTA2, MYH11, SMAD3 and FBN1 ', Human Molecular Genetics, vol. 30, no. 23, pp. 2286-2299 . https://doi.org/10.1093/hmg/ddab190
Human Molecular Genetics
Human Molecular Genetics, 30(23), 2286-2299. Oxford University Press

Aortic aneurysms (AAs) are pathological dilatations of the aorta. Pathogenic variants in genes encoding for proteins of the contractile machinery of vascular smooth muscle cells (VSMCs), genes encoding proteins of the transforming growth factor beta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420d12b6b72536ee5cb8cc7cb77fbc75
https://research.vumc.nl/en/publications/15fd6bf7-89f7-4cdf-b65a-509ac7b80c0a

Regulators of gene expression in Enteric Neural Crest Cells are putative Hirschsprung disease genes

Autor: Katherine C MacKenzie, Marco Metzger, Nikhil Thapar, Arne IJpma, Robert M.W. Hofstra, Dipa Natarajan, Bart J. L. Eggen, Yunia Sribudiani, Alan J. Burns, Duco Schriemer, Ellen Binder

Publikováno v: Developmental Biology, 416(1), 255-265. ACADEMIC PRESS INC ELSEVIER SCIENCE
Developmental Biology, 416(1), 255-265. Elsevier Inc.

The enteric nervous system (ENS) is required for peristalsis of the gut and is derived from Enteric Neural Crest Cells (ENCCs). During ENS development, the RET receptor tyrosine kinase plays a critical role in the proliferation and survival of ENCCs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d17cbd941ea15de1128b6cf9e284f38
https://doi.org/10.1016/j.ydbio.2016.06.004

Abstract 5095: CGH+SNP microarrays for copy-neutral aberration detection in cancer research

Autor: Paige Anderson, Brian J. Peter, Emily M LeProust, Anne Bergstrom Lucas, Maithreyan Srinivasan, Bo Curry, Anniek De Witte, Michael Ruvolo, Arne Ijpma, Stephanie Fulmer-Smentek, Jayati Ghosh, Arjun Vadapalli, Nick Sampas, Ashutosh Ashutosh, Paula Costa

Publikováno v: Cancer Research. 72:5095-5095

Advances in cancer research have greatly benefited from high resolution copy number (CN) measurements provided by oligo array Comparative Genomic Hybridization (aCGH). The addition of single nucleotide polymorphism (SNP) measurements to CGH microarra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e60f33ebecc0220a4d7b47081e0d64e8
https://doi.org/10.1158/1538-7445.am2012-5095