Zobrazeno 1 - 10
of 435
pro vyhledávání: '"Arne Holmgren"'
Autor:
Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Ajanta Chatterji, Angela P. Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi, Chet E. Holterman, Bojan Shutinoski, Juan Li, Travis K. Fehr, Matthew J. LaVoie, Rajiv R. Ratan, Gary S. Shaw, Masashi Takanashi, Nobutaka Hattori, Christopher R. Kennedy, Mary-Ellen Harper, Arne Holmgren, Julianna J. Tomlinson, Michael G. Schlossmacher
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn
Externí odkaz:
https://doaj.org/article/a0cf0ed0ee2143f0a980d7d5a5c6d50a
Autor:
Valeria Scalcon, Alessandra Folda, Maria Giovanna Lupo, Federica Tonolo, Naixuan Pei, Ilaria Battisti, Nicola Ferri, Giorgio Arrigoni, Alberto Bindoli, Arne Holmgren, Lucia Coppo, Maria Pia Rigobello
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102277- (2022)
Glutaredoxin 2 (Grx2) is a glutathione-dependent oxidoreductase that facilitates glutathionylation/de-glutathionylation of target proteins. The main variants of Grx2 are the mitochondrial Grx2a and the cytosolic Grx2c. The aim of this study was to in
Externí odkaz:
https://doaj.org/article/d28614f02f9f4caf890059aedd389671
Autor:
Chuanjiang Dong, Jingxuan Zhou, Peng Wang, Tao Li, Ying Zhao, Xiaoyuan Ren, Jun Lu, Jun Wang, Arne Holmgren, Lili Zou
Publikováno v:
Frontiers in Microbiology, Vol 10 (2020)
As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is a promising antibacterial drug target. Ebselen, an organo-selenium with well-characterized toxicology and pharmacology, was recently reported to have potent antibacterial activity against S
Externí odkaz:
https://doaj.org/article/02e5045582e74a429773ce0375136746
Autor:
Lena Haffo, Jun Lu, Vladimir J. N. Bykov, Sebastin S. Martin, Xiaoyuan Ren, Lucia Coppo, Klas G. Wiman, Arne Holmgren
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The tumor suppressor p53 is commonly inactivated in human tumors, allowing evasion of p53-dependent apoptosis and tumor progression. The small molecule APR-246 (PRIMA-1Met) can reactive mutant p53 in tumor cells and trigger cell death by apo
Externí odkaz:
https://doaj.org/article/5919892998d44e63a8772d90b40e9d3a
Autor:
Lars Bräutigam, Jie Zhang, Kristian Dreij, Linda Spahiu, Arne Holmgren, Hiroshi Abe, Kenneth D. Tew, Danyelle M. Townsend, Michael J. Kelner, Ralf Morgenstern, Katarina Johansson
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 171-179 (2018)
We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal. To elucidate why, we used zebrafish development as a model system an
Externí odkaz:
https://doaj.org/article/6112082f1b8143d8bfa088eb5a31f32c
Autor:
Vasco Branco, Lucia Coppo, Susana Solá, Jun Lu, Cecília M.P. Rodrigues, Arne Holmgren, Cristina Carvalho
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 278-287 (2017)
Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems – glutathione (GSH) and thioredoxin (Trx) systems – are likely target
Externí odkaz:
https://doaj.org/article/e71866dab99747579be1e4fdb45a6ee6
Autor:
Aida Rodriguez-Garcia, David Hevia, Juan C. Mayo, Pedro Gonzalez-Menendez, Lucia Coppo, Jun Lu, Arne Holmgren, Rosa M. Sainz
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 634-647 (2017)
Accumulating evidence suggests that natural bioactive compounds, alone or in combination with traditional chemotherapeutic agents, could be used as potential therapies to fight cancer. In this study, we employed four natural bioactive compounds (curc
Externí odkaz:
https://doaj.org/article/b0e40129d39446a9bcbbc8944e54f153
Autor:
Lili Zou, Jun Lu, Jun Wang, Xiaoyuan Ren, Lanlan Zhang, Yu Gao, Martin E Rottenberg, Arne Holmgren
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1165-1178 (2017)
Abstract Multidrug‐resistant (MDR) Gram‐negative bacteria account for a majority of fatal infections, and development of new antibiotic principles and drugs is therefore of outstanding importance. Here, we report that five most clinically difficu
Externí odkaz:
https://doaj.org/article/35cdb17ce96d4e5e90b30d0bb004aa34
Autor:
Justin R. Prigge, Lucia Coppo, Sebastin S. Martin, Fernando Ogata, Colin G. Miller, Michael D. Bruschwein, David J. Orlicky, Colin T. Shearn, Jean A. Kundert, Julia Lytchier, Alix E. Herr, Åse Mattsson, Matthew P. Taylor, Tomas N. Gustafsson, Elias S.J. Arnér, Arne Holmgren, Edward E. Schmidt
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2771-2781 (2017)
Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively,
Externí odkaz:
https://doaj.org/article/608638e94517493f8c9dd7af8d0965f9
Autor:
Marina Diotallevi, Paola Checconi, Anna Teresa Palamara, Ignacio Celestino, Lucia Coppo, Arne Holmgren, Kahina Abbas, Fabienne Peyrot, Manuela Mengozzi, Pietro Ghezzi
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Glutathione (GSH), a major cellular antioxidant, is considered an inhibitor of the inflammatory response involving reactive oxygen species (ROS). However, evidence is largely based on experiments with exogenously added antioxidants/reducing agents or
Externí odkaz:
https://doaj.org/article/ddec7bfa630a4698a3735d9ddc80995b