Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Arne C Rufer"'
Autor:
Morgan Scott-Dennis, Fikri A. Rafani, Yicheng Yi, Themiya Perera, Clare R. Harwood, Wolfgang Guba, Arne C. Rufer, Uwe Grether, Dmitry B. Veprintsev, David A. Sykes
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The cannabinoid receptor (CBR) subtypes 1 (CB1R) and 2 (CB2R) are key components of the endocannabinoid system (ECS), playing a central role in the control of peripheral pain, inflammation and the immune response, with further roles in
Externí odkaz:
https://doaj.org/article/bd3b602001cb48838825a2f74ab966f7
Autor:
Yves P. Auberson, Paola B. Arimondo, Maria Duca, Sebastian Essig, Uwe Grether, Arne C. Rufer, Gianluca Sbardella, Ulrich Schopfer, Antoni Torrens, Mario van der Stelt, Boris Vauzeilles, Olalla Vázquez, Andrew X. Zhang
Publikováno v:
ChemBioChem. 24
Autor:
Paola Favuzza, Elena Guffart, Marco Tamborrini, Bianca Scherer, Anita M Dreyer, Arne C Rufer, Johannes Erny, Joerg Hoernschemeyer, Ralf Thoma, Georg Schmid, Bernard Gsell, Araceli Lamelas, Joerg Benz, Catherine Joseph, Hugues Matile, Gerd Pluschke, Markus G Rudolph
Publikováno v:
eLife, Vol 6 (2017)
Invasion of erythrocytes by Plasmodial merozoites is a composite process involving the interplay of several proteins. Among them, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) is a crucial component of a ternary complex, includ
Externí odkaz:
https://doaj.org/article/020ed0eebb0d43a8aea76fd5a4619c3b
Autor:
Arne C. Rufer, Michael Hennig
Publikováno v:
Structural Biology in Drug Discovery
Autor:
Thais Gazzi, Benjamin Brennecke, Kenneth Atz, Claudia Korn, David Sykes, Gabriel Forn-Cuni, Patrick Pfaff, Roman C. Sarott, Matthias V. Westphal, Yelena Mostinski, Leonard Mach, Malgorzata Wasinska-Kalwa, Marie Weise, Bradley L. Hoare, Tamara Miljuš, Maira Mexi, Nicolas Roth, Eline J. Koers, Wolfgang Guba, André Alker, Arne C. Rufer, Eric A. Kusznir, Sylwia Huber, Catarina Raposo, Elisabeth A. Zirwes, Anja Osterwald, Anto Pavlovic, Svenja Moes, Jennifer Beck, Matthias Nettekoven, Irene Benito-Cuesta, Teresa Grande, Faye Drawnel, Gabriella Widmer, Daniela Holzer, Tom van der Wel, Harpreet Mandhair, Michael Honer, Jürgen Fingerle, Jörg Scheffel, Johannes Broichhagen, Klaus Gawrisch, Julián Romero, Cecilia J. Hillard, Zoltan V. Varga, Mario van der Stelt, Pal Pacher, Jürg Gertsch, Christoph Ullmer, Peter J. McCormick, Sergio Oddi, Herman P. Spaink, Mauro Maccarrone, Dmitry B. Veprintsev, Erick M. Carreira, Uwe Grether, Marc Nazaré
Publikováno v:
Gazzi, Thais; Brennecke, Benjamin; Atz, Kenneth; Korn, Claudia; Sykes, David; Forn-Cuni, Gabriel; Pfaff, Patrick; Sarott, Roman C; Westphal, Matthias V; Mostinski, Yelena; Mach, Leonard; Wasinska-Kalwa, Malgorzata; Weise, Marie; Hoare, Bradley L; Miljuš, Tamara; Mexi, Maira; Roth, Nicolas; Koers, Eline J; Guba, Wolfgang; Alker, André; ... (2022). Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe. Chemical Science, 13(19), pp. 5539-5545. The Royal Society of Chemistry 10.1039/d1sc06659e
Chemical Science, 13(19), 5539-5545
Chemical Science
Chemical Science, 13(19), 5539-5545
Chemical Science
Despite its essential role in the (patho)physiology of several diseases, CB2R tissue expression profiles and signaling mechanisms are not yet fully understood. We report the development of a highly potent, fluorescent CB2R agonist probe employing str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e61ac61b6e5b29da1ceeb545f2c056
http://hdl.handle.net/11697/192023
http://hdl.handle.net/11697/192023
Autor:
Huaying Zhao, Rodolfo Ghirlando, Carlos Alfonso, Fumio Arisaka, Ilan Attali, David L Bain, Marina M Bakhtina, Donald F Becker, Gregory J Bedwell, Ahmet Bekdemir, Tabot M D Besong, Catherine Birck, Chad A Brautigam, William Brennerman, Olwyn Byron, Agnieszka Bzowska, Jonathan B Chaires, Catherine T Chaton, Helmut Cölfen, Keith D Connaghan, Kimberly A Crowley, Ute Curth, Tina Daviter, William L Dean, Ana I Díez, Christine Ebel, Debra M Eckert, Leslie E Eisele, Edward Eisenstein, Patrick England, Carlos Escalante, Jeffrey A Fagan, Robert Fairman, Ron M Finn, Wolfgang Fischle, José García de la Torre, Jayesh Gor, Henning Gustafsson, Damien Hall, Stephen E Harding, José G Hernández Cifre, Andrew B Herr, Elizabeth E Howell, Richard S Isaac, Shu-Chuan Jao, Davis Jose, Soon-Jong Kim, Bashkim Kokona, Jack A Kornblatt, Dalibor Kosek, Elena Krayukhina, Daniel Krzizike, Eric A Kusznir, Hyewon Kwon, Adam Larson, Thomas M Laue, Aline Le Roy, Andrew P Leech, Hauke Lilie, Karolin Luger, Juan R Luque-Ortega, Jia Ma, Carrie A May, Ernest L Maynard, Anna Modrak-Wojcik, Yee-Foong Mok, Norbert Mücke, Luitgard Nagel-Steger, Geeta J Narlikar, Masanori Noda, Amanda Nourse, Tomas Obsil, Chad K Park, Jin-Ku Park, Peter D Pawelek, Erby E Perdue, Stephen J Perkins, Matthew A Perugini, Craig L Peterson, Martin G Peverelli, Grzegorz Piszczek, Gali Prag, Peter E Prevelige, Bertrand D E Raynal, Lenka Rezabkova, Klaus Richter, Alison E Ringel, Rose Rosenberg, Arthur J Rowe, Arne C Rufer, David J Scott, Javier G Seravalli, Alexandra S Solovyova, Renjie Song, David Staunton, Caitlin Stoddard, Katherine Stott, Holger M Strauss, Werner W Streicher, John P Sumida, Sarah G Swygert, Roman H Szczepanowski, Ingrid Tessmer, Ronald T Toth, Ashutosh Tripathy, Susumu Uchiyama, Stephan F W Uebel, Satoru Unzai, Anna Vitlin Gruber, Peter H von Hippel, Christine Wandrey, Szu-Huan Wang, Steven E Weitzel, Beata Wielgus-Kutrowska, Cynthia Wolberger, Martin Wolff, Edward Wright, Yu-Sung Wu, Jacinta M Wubben, Peter Schuck
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126420 (2015)
Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose o
Externí odkaz:
https://doaj.org/article/3bd91e8f42734f39965350067490e003
Autor:
Mark Rogers-Evans, Matthias Nettekoven, Michel Bouvier, Uwe Grether, Franziska M. Heydenreich, Thais Gazzi, Anja Osterwald, Marc Nazaré, Atsushi Kimbara, Tamara Miljuš, Christoph Ullmer, Christian Le Gouill, Dmitry B. Veprintsev, Arne C. Rufer, Elisabeth A. Zirwes, Wolfgang Guba, Jürgen Fingerle
Cannabinoid CB1 and CB2 receptors are members of the G protein-coupled receptor family, which is the largest class of membrane proteins in the human genome. As part of the endocannabinoid system, they have many regulatory functions in the human body.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5b2aa7bcf5fc2433f62078972394e5
https://doi.org/10.1101/2020.11.09.375162
https://doi.org/10.1101/2020.11.09.375162
Autor:
Sylwia Huber, Wolfgang Guba, Andreas Topp, Joerg Benz, Andreas Ehler, Rosa Maria Rodriguez Sarmiento, Ravi Jagasia, Eva Carolina Hofmann, Melanie N. Hug, Arne C. Rufer
Publikováno v:
Angewandte Chemie (International ed. in English). 60(10)
Genetic, preclinical and clinical data link Parkinson's disease and Gaucher's disease and provide a rational entry point to disease modification therapy via enhancement of β-Glucocerebrosidase (GCase) activity. We discovered a new class of pyrrolo[2
Autor:
Dominique Burger, Daniel Schlatter, Theodor Stoll, Magali Muller, Tabea Grossenbacher, Sylwia Huber, Philipp Koldewey, Andrea D'Osualdo, Melanie N. Hug, Arne C. Rufer, Kirsten Richter, Fabio Casagrande, Markus G. Rudolph
Publikováno v:
J Biol Chem
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Activation of the T cell receptor (TCR) results in binding of the adapter protein Nck (noncatalytic region of tyrosine kinase) to the CD3ϵ subunit of the TCR. The interaction was suggested to be important for the amplification of TCR signals and is
Autor:
Natasha L. Grimsey, Dmitry B. Veprintsev, Roman C. Sarott, Teresa Grande, Patrick Pfaff, Jürg Gertsch, Pal Pacher, Erick M. Carreira, Christoph Ullmer, Hermon Asmelash, Pattarin Hompluem, Svenja Moes, Daniela Holzer, Catarina Raposo, William R. Drobyski, Sylwia Huber, Jennifer Beck, Uwe Grether, Marc Nazaré, Claudia Korn, Zoltán Varga, Eline J. Koers, Jacopo Piovesan, Irene Benito-Cuesta, Klaus Gawrisch, Matthias Westphal, Benjamin Brennecke, Gabriella Widmer, Yurii Saroz, Eric Kusznir, Tom van der Wel, Anto Pavlovic, Kenneth Atz, Man C Vong, Tamara Miljuš, Peter J. McCormick, Mauro Maccarrone, Harpreet Mandhair, Samuel Ruiz de Martín Esteban, Sergio Oddi, Yelena Mostinski, Julián Romero, Elisabeth A. Zirwes, Anja Osterwald, Jürgen Fingerle, Cecilia J. Hillard, David A. Sykes, Alexei Yeliseev, Faye M. Drawnel, Mario van der Stelt, Marie Weise, Arne C. Rufer, Cheng-Yin Yuan, Thais Gazzi, Nicolas J. Roth, Michael Honer, Wolfgang Guba
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, 142(40), 16953-16964
Journal of the American Chemical Society, 142(40), 16953-16964
Pharmacological modulation of cannabinoid type 2 receptor (CB2R) holds promise for the treatment of numerous conditions, including inflammatory diseases, autoimmune disorders, pain, and cancer. Despite the significance of this receptor, researchers l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1774cb215365081fabff5fd4b151b22f
http://hdl.handle.net/11697/158602
http://hdl.handle.net/11697/158602