Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS

Autor: Laura J. Pallett, Leo Swadling, Mariana Diniz, Alexander A. Maini, Marius Schwabenland, Adrià Dalmau Gasull, Jessica Davies, Stephanie Kucykowicz, Jessica K. Skelton, Niclas Thomas, Nathalie M. Schmidt, Oliver E. Amin, Upkar S. Gill, Kerstin A. Stegmann, Alice R. Burton, Emily Stephenson, Gary Reynolds, Matt Whelan, Jenifer Sanchez, Roel de Maeyer, Clare Thakker, Kornelija Suveizdyte, Imran Uddin, Ana M. Ortega-Prieto, Charlotte Grant, Farid Froghi, Giuseppe Fusai, Sabela Lens, Sofia Pérez-del-Pulgar, Walid Al-Akkad, Giuseppe Mazza, Mahdad Noursadeghi, Arne Akbar, Patrick T. F. Kennedy, Brian R. Davidson, Marco Prinz, Benjamin M. Chain, Muzlifah Haniffa, Derek W. Gilroy, Marcus Dorner, Bertram Bengsch, Anna Schurich, Mala K. Maini

Publikováno v: Nature. 614:334-342

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d6d3898868eddb2dc8c6aa59e2376c1
https://doi.org/10.1038/s41586-022-05645-6

P167 Overcoming rituximab resistance in autoimmune disease: back to basics

Autor: Kavina Shah, Christian Klein, Geraldine Cambridge, Debajit Sen, Madhura Castelino, Arne Akbar, David A Isenberg, Maria Leandro, Venkat R Reddy

Publikováno v: Rheumatology. 62

Background/Aims Previous research into B cell biomarkers of poor response to the anti-CD20 drug rituximab in autoimmune disease relates to insufficient B cell depletion. Expansion of memory B cell (MBC) subsets were also associated with poorer respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc50f7f485e27ede2ebdb4817031b2c3
https://doi.org/10.1093/rheumatology/kead104.208

Post-resolution macrophage-derived lipids shapes long-term tissue immunity and integrity

Autor: Karen Feehan, Hannah Bridgewater, Jan Stenkiewicz-Witeska, John Ferguson, Matthias Mack, JEREMY BROWN, Giuseppe Ercoli, Connar Mawer, Arne Akbar, Parinaaz Jalali, Olivia Bracken, James Glanville, Anna Nicolaou, Alexandra Kendall, Michelle Sugimoto, Derek Gilroy

Resolving inflammation is thought to return the affected tissue back to homeostasis. However, we show that within days following resolution of Streptococcus pneumonia-triggered lung inflammation there is an influx of antigen specific lymphocytes with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a340fca35532da64bd122653009a9977
https://doi.org/10.21203/rs.3.rs-2162680/v1

Age-related changes in collagen mechanical properties detected by high-resolution acoustic microscopy and AFM

Autor: Anna R. Maeva, Adam P. Strange, Inna Seviaryna, Colin Hopper, Conal Perrett, Hugh Trahair, Oliver Devine, Arne Akbar

Publikováno v: Optical Elastography and Tissue Biomechanics VIII.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e26793a08216dbb73e8730c905c12d33
https://doi.org/10.1117/12.2585637

Increased levels of GM-CSF and CXCL10 and low CD8⁺ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people.

Autor: Poisson, Johanne^1,2,3 (AUTHOR), El-Sissy, Carine^4,5,6 (AUTHOR), Serret-Larmande, Arnaud⁷ (AUTHOR), Smith, Nikaïa⁸ (AUTHOR), Lebraud, Morgane⁶ (AUTHOR), Augy, Jean-Loup⁹ (AUTHOR), Conti, Catherine^1,2 (AUTHOR), Gonnin, Cécile^6,10 (AUTHOR), Planquette, Benjamin¹¹ (AUTHOR), Arlet, Jean-Benoît^12,13 (AUTHOR), Hermann, Bertrand^14,15 (AUTHOR), Charbit, Bruno¹⁶ (AUTHOR), Pastre, Jean¹¹ (AUTHOR), Devaux, Floriane⁶ (AUTHOR), Ladavière, Cyrielle⁶ (AUTHOR), Lim, Lydie⁶ (AUTHOR), Ober, Pauline⁶ (AUTHOR), Cannovas, Johanna² (AUTHOR), Biard, Lucie⁷ (AUTHOR), Gulczynski, Marie-Christelle¹⁷ (AUTHOR)

Publikováno v: Immunity & Ageing. 5/7/2024, Vol. 21, p1-14. 14p.