Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Arne, Skerra"'
Autor:
Benedikt Zott, Lea Nästle, Christine Grienberger, Felix Unger, Manuel M. Knauer, Christian Wolf, Aylin Keskin-Dargin, Anna Feuerbach, Marc Aurel Busche, Arne Skerra, Arthur Konnerth
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Hyperactivity mediated by synaptotoxic β-amyloid (Aβ) oligomers is one of the earliest forms of neuronal dysfunction in Alzheimer’s disease. In the search for a preventive treatment strategy, we tested the effect of scavenging Aβ peptid
Externí odkaz:
https://doaj.org/article/b639df210aa048939f610e47664d18d0
Autor:
Stefan Achatz, Arne Skerra
Publikováno v:
FEBS Open Bio, Vol 14, Iss 6, Pp 888-905 (2024)
The development of the Escherichia coli K‐12 laboratory strains JM83, JM109 and XL1‐Blue was instrumental in early gene technology. We report the comprehensive genome sequence analysis of JM83 and XL1‐Blue using Illumina and Oxford Nanopore tec
Externí odkaz:
https://doaj.org/article/5b671c6fdfe74658b2eb6380ca72eb83
Autor:
Martin Bender, Jan-Michael Abicht, Bruno Reichart, Elisabeth Neumann, Julia Radan, Maren Mokelke, Ines Buttgereit, Maria Leuschen, Felicia Wall, Sebastian Michel, Reinhard Ellgass, Stig Steen, Audrius Paskevicius, Andreas Lange, Barbara Kessler, Elisabeth Kemter, Nikolai Klymiuk, Joachim Denner, Antonia W. Godehardt, Ralf R. Tönjes, Jonathan M. Burgmann, Constança Figueiredo, Anastasia Milusev, Valentina Zollet, Neda Salimi-Afjani, Alain Despont, Robert Rieben, Stephan Ledderose, Christoph Walz, Christian Hagl, David Ayares, Eckhard Wolf, Michael Schmoeckel, Paolo Brenner, Uli Binder, Michaela Gebauer, Arne Skerra, Matthias Längin
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1927 (2024)
The blockade of the CD40/CD40L immune checkpoint is considered essential for cardiac xenotransplantation. However, it is still unclear which single antibody directed against CD40 or CD40L (CD154), or which combination of antibodies, is better at prev
Externí odkaz:
https://doaj.org/article/8c1badf713bc4998ad88ccdb88bead35
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 967 (2024)
Cumulative evidence from several pre-clinical studies suggests that restoration of plasma DNase activity in a thrombo-inflammatory state may improve clinical outcomes. Following injury, hyperactivated immune cells release large amounts of granular pr
Externí odkaz:
https://doaj.org/article/c4dc4976bae2448e99b35eaca69e7ce6
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Cryo-EM structure determination of relatively small and flexible membrane proteins at high resolution is challenging. Increasing the size and structural features by binding of high affinity proteins to the biomolecular target allows for bett
Externí odkaz:
https://doaj.org/article/6f00c2e103714c4a90a407cbed14e528
Autor:
Emanuel Peplau, Francesco De Rose, Andreas Eichinger, Sybille Reder, Markus Mittelhäuser, Giorgia Scafetta, Markus Schwaiger, Wolfgang A. Weber, Armando Bartolazzi, Calogero D’Alessandria, Arne Skerra
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The lack of a non-invasive test for malignant thyroid nodules makes the diagnosis of thyroid cancer (TC) challenging. Human galectin-3 (hGal3) has emerged as a promising target for medical TC imaging and diagnosis because of its exclusive ov
Externí odkaz:
https://doaj.org/article/f202779add984825b42f13aa3af80c55
Autor:
Katherine Griffiths, Uli Binder, William McDowell, Rita Tommasi, Mark Frigerio, William G. Darby, Chris G. Hosking, Lionel Renaud, Matthias Machacek, Peter Lloyd, Arne Skerra, Michael Foley
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1331-1340 (2019)
Single domain antibodies that combine antigen specificity with high tissue penetration are an attractive alternative to conventional antibodies. However, rapid clearance from the bloodstream owing to their small size can be a limitation of therapeuti
Externí odkaz:
https://doaj.org/article/7654a6ff13a34f68ab979ca90ac88158
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The protein family of Lipocalins is ubiquitously present throughout the tree of life, with the exception of the phylum Archaea. Phylogenetic relationships of chordate Lipocalins have been proposed in the past based on protein sequence similarities, b
Externí odkaz:
https://doaj.org/article/e8878d0bd60341fabc1c378e0cfe19ab
Autor:
Volker Morath, Corinna Brandt, Friedrich-Christian Deuschle, Claudia T. Mendler, Birgit Blechert, Dominik Summer, Cyril Barinka, Clemens Decristoforo, Wolfgang A. Weber, Markus Schwaiger, Arne Skerra
Publikováno v:
Molecular Pharmaceutics. 20:2490-2501
Autor:
Laura Job, Anja Köhler, Andreas Eichinger, Mauricio Testanera, Benjamin Escher, Franz Worek, Arne Skerra
Publikováno v:
Biochemistry. 62:942-955