Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Arne, Ring"'
Autor:
Gerry P McCann, Jamal N Khan, John P Greenwood, Sheraz A Nazir, Miles Dalby, Nick Curzen, Simon Hetherington, Damian J Kelly, Daniel J Blackman, Arne Ring, Charles Peebles, Joyce Wong, Thiagarajah Sasikaran, Marcus Flather, Howard Swanton, Anthony H Gershlick
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 3, Iss 1 (2016)
Background: Complete revascularisation in patients with multivessel disease who are treated with primary percutaneous coronary intervention (PPCI) may improve outcomes compared with an infarct-related artery (IRA)-only strategy. However, non-IRA perc
Externí odkaz:
https://doaj.org/article/fbe5b919281949fc8ca419f7e06dcf0d
Publikováno v:
Open Journal of Mathematical Analysis. 4:84-97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a63e3f85018879ade0d3ebc0156cac8
https://doi.org/10.30538/psrp-oma2020.0055
https://doi.org/10.30538/psrp-oma2020.0055
Autor:
Arne Ring, Martin J. Wolfsegger
Publikováno v:
Br J Clin Pharmacol
The recently finalised and published guideline ICH E9 (R1) introduced a new framework for the statistical analysis of clinical trials, namely that of “estimands”. While the framework was originally developed for the analysis of late‐phase trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1aa7270b091641e9fc70911bc66818
https://doi.org/10.1111/bcp.14233
https://doi.org/10.1111/bcp.14233
Autor:
Pavel Balazki, Sonja Böhm, Dietrich W. Beelen, Frederico Severino Martins, Stephan Schaller, Joachim Baumgart, Arne Ring, Ralf A. Hilger, Claudia Hemmelmann
Publikováno v:
British journal of clinical pharmacology. 88(4)
Aims: The aim of this work is the development of a mechanistic physiologically-based pharmacokinetic (PBPK) model using in vitro to in vivo extrapolation to conduct a drug-drug interaction (DDI) assessment of treosulfan against two cytochrome p450 (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b0d7bd430278c1a4bf5ab2f371ec4e
https://pubmed.ncbi.nlm.nih.gov/34519068
https://pubmed.ncbi.nlm.nih.gov/34519068
Autor:
David F. Heigener, Arne Ring, Achim Rittmeyer, Gert Hoeffken, Markus Pietsch, Karl-Matthias Deppermann, Dieter Wuerflein, Matthias Feurer, Roland Maria Huber
Publikováno v:
TumorDiagnostik & Therapie. 38:634-640
Zusammenfassung Hintergrund Auch für ältere Patienten (> 70 Jahre) ist der Nutzen einer palliativen Chemotherapie beim NSCLC durch Studien gut belegt. Wir haben eine multizentrische, prospektive Datensammlung über die Therapieentscheidungen bei Pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cede9215d91674ae214882e216c8ff
https://doi.org/10.1055/s-0043-120557
https://doi.org/10.1055/s-0043-120557
Publikováno v:
British Journal of Clinical Pharmacology. 83:1159-1162
Research in clinical pharmacology covers a wide range of experiments, trials and investigations: clinical trials, systematic reviews and meta-analyses of drug usage after market approval, the investigation of pharmacokinetic–pharmacodynamic relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4983f42b034826222c602441e050cfe7
https://doi.org/10.1111/bcp.13254
https://doi.org/10.1111/bcp.13254
Publikováno v:
Statistics in medicine, 39(30):4551-4573
In late stage drug development, the experimental drug is tested in a diverse study population within the relevant indication. In order to receive marketing authorization, robust evidence for the therapeutic efficacy is crucial requiring investigation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e2902563edd3003ad645362450517f
https://pubmed.ncbi.nlm.nih.gov/33105519
https://pubmed.ncbi.nlm.nih.gov/33105519
Publikováno v:
Br J Clin Pharmacol
Aims Bioequivalence (BE) trials aim to demonstrate that the 90% confidence interval of the T/R-ratio of the pharmacokinetic metrics between two formulations (test [T] and reference [R]) of a drug is fully included in the acceptance interval [0.80, 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e85ef9795ac9cca3eaaa529ca0d6a3c
https://europepmc.org/articles/PMC6783617/
https://europepmc.org/articles/PMC6783617/
Autor:
Thiagarajah Sasikaran, Marcus Flather, Sheraz A Nazir, Joyce Wong, Daniel J. Blackman, Howard Swanton, Jamal N Khan, Miles Dalby, Charles Peebles, Arne Ring, Anthony H. Gershlick, Gerry P McCann, Damian J. Kelly, Simon Hetherington, John P Greenwood, Nick Curzen
Publikováno v:
Journal of the American College of Cardiology. 66:2713-2724
Background Complete revascularization may improve outcomes compared with an infarct-related artery (IRA)-only strategy in patients being treated with primary percutaneous coronary intervention (PPCI) who have multivessel disease presenting with ST-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f4c4d305e023ceb9b3c6eb5e1c9686
https://doi.org/10.1016/j.jacc.2015.09.099
https://doi.org/10.1016/j.jacc.2015.09.099
Publikováno v:
New Frontiers of Biostatistics and Bioinformatics ISBN: 9783319993881
Confirmatory clinical trials that aim to demonstrate the efficacy of drugs are typically performed in broad patient populations so that the patient population is usually heterogeneous with respect to demographic variables and medical conditions. Ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2dc293892525a2879bbca3b84d985b3
https://doi.org/10.1007/978-3-319-99389-8_10
https://doi.org/10.1007/978-3-319-99389-8_10