Is kallikrein-8 a blood biomarker for detecting amnestic mild cognitive impairment? Results of the population-based Heinz Nixdorf Recall study

Autor: Sara Schramm, Martha Jokisch, Karl-Heinz Jöckel, Arne Herring, Kathy Keyvani

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)

Abstract Background Kallikrein-8 (KLK8) might be an early blood-biomarker of Alzheimer’s disease (AD). We examined whether blood KLK8 is elevated in persons with amnestic mild cognitive impairment (aMCI) which is a precursor of AD, compared to cogn

Externí odkaz: https://doaj.org/article/bdd1adea81304eeca14fe392b421c78e

Late running is not too late against Alzheimer's pathology

Autor: Arne Herring, Yvonne Münster, Judith Metzdorf, Bastien Bolczek, Sarah Krüssel, David Krieter, Ilkay Yavuz, Fro Karim, Constanze Roggendorf, Anthony Stang, Yachao Wang, Dirk M. Hermann, Sarah Teuber-Hanselmann, Kathy Keyvani

Publikováno v: Neurobiology of Disease, Vol 94, Iss , Pp 44-54 (2016)

In the last decade a vast number of animal studies have produced overwhelming evidence that exercise not only compensates for memory loss by increasing brain plasticity and cognitive reserve but also directly counteracts Alzheimer-like pathology when

Externí odkaz: https://doaj.org/article/d519ced07e8b45b3848009bb2ba55546

Compromised Hippocampal Neuroplasticity in the Interferon-α and Toll-like Receptor-3 Activation-Induced Mouse Depression Model

Autor: Tayana Silva de Carvalho, Dirk M. Hermann, Santiago Camblor-Perujo, Kathy Keyvani, Tim Hagenacker, Eduardo H. Sanchez-Mendoza, Christoph Kleinschnitz, Sujoy Bera, Michael Fleischer, Linda-Isabell Schmitt, Natalia L. Kononenko, Luiza Martins Nascentes-Melo, Egor Dzyubenko, Markus Leo, Arne Herring

Publikováno v: Molecular Neurobiology

Disrupted neuronal plasticity due to subtle inflammation is considered to play a fundamental role in the pathogenesis of major depressive disorder. Interferon-α (IFN-α) potentiates immune responses against viral pathogens that induce toll-like rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac84c82097f3b6150435fcf159bf8e96
https://doi.org/10.1007/s12035-020-01927-0

CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer’s disease

Autor: Andreas Stang, Jan Rekowski, Markus Otto, Kathy Keyvani, Karl-Heinz Jöckel, Herrmann Esselmann, Hayrettin Tumani, Jonathan Vogelgsang, Sarah Teuber-Hanselmann, Christine A. F. von Arnim, Arne Herring, Kathrin Reetz, Jens Wiltfang

Publikováno v: Journal of neurology, neurosurgery, and psychiatry 91(1), 40-48 (2020). doi:10.1136/jnnp-2019-321073
Journal of Neurology, Neurosurgery, and Psychiatry

ObjectiveThere is still an urgent need for supportive minimally invasive and cost-effective biomarkers for early diagnosis of Alzheimer’s disease (AD). Previous work in our lab has identified Kallikrein-8 (KLK8) as a potential candidate since it sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f604233d4c49e016758e5730cb2980b0
https://doi.org/10.1136/jnnp-2019-321073

Repeated Systemic Treatment with Rapamycin Affects Behavior and Amygdala Protein Expression in Rats

Autor: Laura Lückemann, Matthew J Haight, Julia Kirchhof, Arne Herring, Ivo Bendix, Manfred Schedlowski, Kathy Keyvani, Meike Unteroberdörster, Martin Hadamitzky

Publikováno v: International Journal of Neuropsychopharmacology

Background: Clinical data indicate that therapy with small-molecule immunosuppressive drugs is frequently accompanied by an incidence rate of neuropsychiatric symptoms. In the current approach, we investigated in rats whether repeated administration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda96105349451df64dbc32435d2fd3f
http://europepmc.org/articles/PMC6007742