Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Arne, Bartol"'
Autor:
Iris an der Heiden, Guido Schiffhorst, Laura Müller, Martin Albrecht, Arne Bartol, Stefanie Wiberny
Publikováno v:
Health Economics Review, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Background Based on the legal framework laid down in section 130b (9) of Book V of the German Social Code, various criteria are relevant for the negotiated price for new patented drugs in Germany. European reference prices (ERPs) are one cri
Externí odkaz:
https://doaj.org/article/f9fcd91f3d1a4e0db374bd87ae824dc0
Publikováno v:
Health Economics Review, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Aim The productivity of pharmaceutical research and development (R&D) investments is declining due to high failure rates in clinical research. Recently, the US Food and Drug Administration (FDA) acknowledged that adaptive designs can make dr
Externí odkaz:
https://doaj.org/article/277c7a064aa94635afd7778b22dc3233
Autor:
Arne, Bartol, Katrin, Dressler, Peter, Kaskel, Christiane, Landsberg, Cornelia, Lechner, Marco, Petschulies
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 149:2637-2645
2021 marks the tenth anniversary of the AMNOG process and brought with it a new German administration-two good reasons to take stock of where we stand today, what has been achieved so far, and how the path of early benefit assessments in Germany shou
Autor:
Martin Teichert, Laura Milde, Annegret Holm, Laura Stanicek, Nicolas Gengenbacher, Soniya Savant, Tina Ruckdeschel, Zulfiyya Hasanov, Kshitij Srivastava, Junhao Hu, Stella Hertel, Arne Bartol, Katharina Schlereth, Hellmut G. Augustin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The angiopoietins regulate vascular maturation, angiogenesis and lymphangiogenesis via their Tie receptors that were long believed to be endothelium-specific. Here the authors show that angiopoietins activate and control pericyte function through per
Externí odkaz:
https://doaj.org/article/981a987e79e44cc08ee1f10a3f710c40
Autor:
Arne Bartol, Katrin Dreßler, Peter Kaskel, Christiane Landsberg, Cornelia Lechner, Marco Petschulies
Publikováno v:
Forum. 37:84-90
Autor:
Kshitij Srivastava, Annegret Holm, Nicolas Gengenbacher, Stella Hertel, Junhao Hu, Tina Ruckdeschel, Martin Teichert, Soniya Savant, Zulfiyya Hasanov, Katharina Schlereth, Laura Milde, Arne Bartol, Hellmut G. Augustin, Laura Stanicek
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expressed at lower levels by pericytes and it
Autor:
Yvonne Kienast, Elias K. Loos, Kshitij Srivastava, Christian Klein, Philipp Seidel, Sila Appak, Thomas Wieland, Moritz Felcht, Simone Kutschera, Emmanouil Chavakis, Dorothee Terhardt, Eva Besemfelder, Alexander Schering, Hellmut G. Augustin, Robert Luck, Akiyoshi Uemura, Christiane Vettel, Junhao Hu, Susanne Bartels, Arne Bartol, Sergij Goerdt, Markus Thomas
Publikováno v:
Journal of Clinical Investigation. 122:1991-2005
Angiopoietin-2 (ANG-2) is a key regulator of angiogenesis that exerts context-dependent effects on ECs. ANG-2 binds the endothelial-specific receptor tyrosine kinase 2 (TIE2) and acts as a negative regulator of ANG-1/TIE2 signaling during angiogenesi
Autor:
Hellmut G. Augustin, Joycelyn Wüstehube, Anja Telzerow, M. Gordian Adam, Andreas Fischer, Arne Bartol, Sven S. Liebler, Stefanie E. Herberich, René Brütsch
Publikováno v:
Circulation Research. 107:592-601
Rationale: The ICAP1 (integrin cytoplasmic domain–associated protein-1) is a specific intracellular binding protein of β1-integrins and the cerebral cavernous malformation (CCM) protein CCM1. ICAP1 recruits CCM1 to the cell membrane and activates
Publikováno v:
Tumor-Associated Fibroblasts and their Matrix ISBN: 9789400706583
In blood vessels, the crosstalk between vascular endothelial cells and mural cells (pericytes/vascular smooth muscle cells) play a central role in the regulation of vascular formation, maturation, remodeling, stabilization and function. During embryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd1d6224b13d8e51cf3f7ac1209ff355
https://doi.org/10.1007/978-94-007-0659-0_5
https://doi.org/10.1007/978-94-007-0659-0_5
Autor:
Arne Bartol, Joycelyn Wüstehube, Yuan Zhu, Sven S. Liebler, Ute Felbor, Hellmut G. Augustin, Andreas Fischer, René Brütsch, Ulrich Sure
Cerebral cavernous malformations (CCM) are frequent vascular abnormalities caused by mutations in one of the CCM genes. CCM1 (also known as KRIT1) stabilizes endothelial junctions and is essential for vascular morphogenesis in mouse embryos. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1e0e69d7811bcd338e3a45ede6fdea
https://www.ncbi.nlm.nih.gov/pubmed/20616044
https://www.ncbi.nlm.nih.gov/pubmed/20616044