Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Arndt W Schmidt"'
Autor:
Daniel Auguin, Julien Robert-Paganin, Stéphane Réty, Carlos Kikuti, Amandine David, Gabriele Theumer, Arndt W. Schmidt, Hans-Joachim Knölker, Anne Houdusse
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Inherited cardiomyopathies are common cardiac diseases worldwide, leading in the late stage to heart failure and death. The most promising treatments against these diseases are small molecules directly modulating the force produced by β-car
Externí odkaz:
https://doaj.org/article/363d3a02b7d54aa8bbcb3c56b4a01f3f
Autor:
Vitali Matyash, Eugeni V Entchev, Fanny Mende, Michaela Wilsch-Bräuninger, Christoph Thiele, Arndt W Schmidt, Hans-Joachim Knölker, Samuel Ward, Teymuras V Kurzchalia
Publikováno v:
PLoS Biology, Vol 2, Iss 10, p e280 (2004)
Upon starvation or overcrowding, Caenorhabditis elegans interrupts its reproductive cycle and forms a specialised larva called dauer (enduring). This process is regulated by TGF-beta and insulin-signalling pathways and is connected with the control o
Externí odkaz:
https://doaj.org/article/3de4dd8da18f45f7a66c52e35c1f5196
Publikováno v:
Synthesis. 50:2516-2522
We describe the first total synthesis of the pyrano[3,2-a]carbazole alkaloid 7-isovaleryloxy-8-methoxygirinimbine, using a palladium(II)-catalyzed double C–H-bond activation for construction of the carbazole framework and a phenylboronic acid catal
Autor:
Raphael F. Fritsche, Olga Kataeva, Sebastian K. Kutz, Christian Brütting, Carsten Börger, Arndt W. Schmidt, Hans-Joachim Knölker
Publikováno v:
Chemistry - A European Journal. 24:458-470
We describe the synthesis of 1,1'- and 2,2'-bicarbazoles by oxidative homocoupling of 2- and 1-hydroxycarbazoles. The oxidative coupling using catalytic amounts of F16 PcFe can be applied to both groups of substrates. Although F16 PcFe generally prov
Publikováno v:
European Journal of Organic Chemistry. 2017:3288-3300
We describe the first total synthesis of the cytotoxic carbazole alkaloid excavatine-A (1). The carbazole framework was constructed via double C-H bond activation of a diarylamine using our palladium(II)-catalyzed oxidative cyclization. Treatment of
Publikováno v:
Synthesis. 49:275-292
We describe the total synthesis of murrayafoline-B and seven carbazole-1,4-quinone alkaloids. A palladium(II)-catalyzed oxidative cyclization is used to construct the carbazole skeleton. Pyran annulation and oxidation provide pyrayaquinone-A, -B, and
Flavonoid Glycosides from the Aerial Parts of Polygonatum odoratum (Mill.) Druce Growing in Mongolia
Autor:
Chunsriimyatav Ganbaatar, Margit Gruner, Dumaa Mishig, Regdel Duger, Arndt W. Schmidt, Hans-Joachim Knölker
Publikováno v:
The Open Natural Products Journal. 8:1-7
Autor:
Heinrich Schnitzler, Ronny Hesse, Konstanze K. Julich-Gruner, Christian Schuster, Arndt W. Schmidt, Anne Jäger, Hans-Joachim Knölker
Publikováno v:
The Journal of Organic Chemistry. 80:5666-5673
We describe efficient synthetic routes to murrayamine A (mukoenine C), O-methylmurrayamine A, mahanine, O-methylmahanine, and murrayamine D and the first total syntheses of murrayamine E, I, and K. Key steps are a palladium-catalyzed construction of
Publikováno v:
Tetrahedron. 71:3485-3490
The palladium-catalyzed construction of the carbazole framework provides an efficient access to 3-hydroxy-6-methylcarbazole (glycozolinine) (5). Regioselective annulation of a pyran ring at glycozolinine (5) using either a C5- or a C10-building block
Publikováno v:
Chemistry - A European Journal. 20:9504-9509
The DIBAL-H promoted reductive pyran ring opening of dialkylpyrano[3,2-a]carbazoles provides a direct access to a broad range of prenyl- and geranyl-substituted carbazoles. Formation of a pyran ring followed by reductive ring opening represents a new