Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Arndt Rohwedder"'
Autor:
Christopher M. Jones, Arndt Rohwedder, Kin Man Suen, Safoura Zahed Mohajerani, Antonio N. Calabrese, Sabine Knipp, Mark T. Bedford, John E. Ladbury
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35480- (2024)
Receptor tyrosine kinase (RTK) overexpression is linked to the development and progression of multiple cancers. RTKs are classically considered to initiate cytoplasmic signalling pathways via ligand-induced tyrosine phosphorylation, however recent ev
Externí odkaz:
https://doaj.org/article/756db033cc9a4969828da63cff6be9ba
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Receptor tyrosine kinases (RTKs) are highly regulated, single pass transmembrane proteins, fundamental to cellular function and survival. Aberrancies in regulation lead to corruption of signal transduction and a range of pathological outcome
Externí odkaz:
https://doaj.org/article/da6ab08961324858bf419780f90c8fa2
Autor:
Sophie E. Ketchen, Filomena O. Gamboa-Esteves, Sean E. Lawler, Michal O. Nowicki, Arndt Rohwedder, Sabine Knipp, Sally Prior, Susan C. Short, John E. Ladbury, Anke Brüning-Richardson
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 9 (2021)
Cancer cell invasion is a precondition for tumour metastasis and represents one of the most devastating characteristics of cancer. The development of drugs targeting cell migration, known as migrastatics, may improve the treatment of highly invasive
Externí odkaz:
https://doaj.org/article/b3ae45dc331647029ff3446020ce20a5
Autor:
Claus C. Glüer, Susanne Sebens, Eva Peschke, Kerstin Lüdtke-Buzug, Tuula Peñate Medina, Jan-Bernd Hövener, Holger Kalthoff, Kalevi Kairemo, Arndt Rohwedder, Susann Boretius, Charlotte Hauser, Oula Peñate Medina, Olga Will, Lia Appold, Marcus Bötcher, Qi Ling, Robert J. Tower, Lukas Huber, Carola Heneweer, Rolf Mentlein, Fatma Ashkenani
Publikováno v:
Current Pharmaceutical Design. 28:313-323
Background: Pancreatic ductal adenocarcinoma (PDAC), which ranks forth on the cancer-related death statistics still is both a diagnostic and a therapeutic challenge. Adenocarcinoma of the exocrine human pancreas originates in most instances from mali
Autor:
Arndt Rohwedder, Sabine Knipp, Filomena Esteves, Michael Hale, Darren Treanor, Anke Bruning-Richardson
Publikováno v:
Neuro-Oncology. 24:iv13-iv13
AIMS A faithful representation of real tumour conditions in vivo such as a 3D glioma spheroid in a 3D experimental setting has become highly desirable for brain tumour research as it aids the study of tumour behaviour such as cell invasion and initia
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Receptor tyrosine kinases (RTKs) are highly regulated, single pass transmembrane proteins, fundamental to cellular function and survival. Aberrancies in regulation lead to corruption of signal transduction and a range of pathological outcomes. Althou
Autor:
Claus-C. Glüer, Fabian Mertens, Eike Kraas, Olga Will, Susanne Sebens, Yahya Açil, Kalevi Kairemo, Regina Scherließ, Mirko Gerle, Kunliang Luo, Jana Humbert, Arndt Rohwedder, Christabel Damoah, Hanwen Zhu, Tuula Peñate-Medina, Jörg Wiltfang, Oula Penate-Medina
Publikováno v:
Current pharmaceutical design. 26(31)
Background: Nanoparticle imaging and tracking the release of the loaded material from the nanoparticle system have attracted significant attention in recent years. If the release of the loaded molecules could be monitored reliably in vivo, it would s
Autor:
Arndt Rohwedder, Anke Brüning-Richardson, Nina Struve, Sophie Taylor, Alistair Curd, Sabine Knipp, Michelle Peckham, John E. Ladbury, Susan C Short
Publikováno v:
Neuro-Oncology. 19:vi22-vi22
One of the most devastating hallmarks of cancer is cell migration/invasion, a prerequisite for tumour metastasis. Targeting this cellular phenomenon offers an opportunity to improve the treatment of invasive and highly migratory tumours such as Gliob
Publikováno v:
bchm. 390:545-549
Sucrase-isomaltase (SI) is a highly N- and O-glycosylated intestinal brush border membrane protein. SI is sorted with high fidelity to the apical membrane via O-linked glycans that mediate its association with lipid rafts or detergent-resistant membr
Publikováno v:
Journal of cell science. 127(Pt 14)
It is unclear how changes in lipid droplet size and number are regulated - for example, it is not known whether this involves a signalling pathway or is directed by cellular lipid uptake. Here, we show that oleic acid stimulates lipid droplet formati