Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Arndt Manzel"'
Autor:
Mathias Mäurer, Klaus Tiel-Wilck, Eckard Oehm, Nils Richter, Michael Springer, Patrick Oschmann, Arndt Manzel, Stefanie Hieke-Schulz, Vera Zingler, Julia A. Kandenwein, Tjalf Ziemssen, Ralf A. Linker
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 12 (2019)
Background: With a large array of disease modifying therapies (DMTs) for relapsing-remitting MS (RRMS), identifying the optimal treatment option for the individual patient is challenging and switching of immunotherapies is often required. The objecti
Externí odkaz:
https://doaj.org/article/0fd09a02da39460790244fd7336013fa
Autor:
Stefanie Jörg, Denis A. Akkad, Anne Waschbisch, Nils Helge Schebb, Caroline May, Alexander Duscha, Stefan Kempa, Aiden Haghikia, Ralf Gold, Diana A. Grohme, Markus Kleinewietfeld, Jan Thöne, Johannes Berg, Annika I. Ostermann, András Balogh, Nicola Wilck, Dominik N. Müller, Anna Hammer, Seray Demir, Ralf A. Linker, Arndt Manzel, De-Hyung Lee
Publikováno v:
Immunity. 43(4):817-829
SummaryGrowing empirical evidence suggests that nutrition and bacterial metabolites might impact the systemic immune response in the context of disease and autoimmunity. We report that long-chain fatty acids (LCFAs) enhanced differentiation and proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea8c7f3ccc7e1c3a92bac89af9eb58b
Autor:
Refik Pul, Stefanie Jörg, Rebecca Wolf, Karoline Gropengießer, Vikramjeet Singh, Laura Salinas Tejedor, Anna Hammer, Ralf A. Linker, Darius Moharregh-Khiabani, Franca Vulinovic, Arndt Manzel, Nora Schäfer, De-Hyung Lee, Elke Voss, Thomas Skripuletz, Wolfgang Baumgärtner, Martin Stangel, Diane Degen, Ralf Gold, Viktoria Gudi
Publikováno v:
Brain. 138:398-413
Neuroprotective approaches for central nervous system regeneration have not been successful in clinical practice so far and compounds that enhance remyelination are still not available for patients with multiple sclerosis. The objective of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af1d490cd5f7a0275c5d9e2e1abb179d
https://doi.org/10.1093/brain/awu358
https://doi.org/10.1093/brain/awu358
Autor:
Arndt Manzel, Ralf A. Linker, Eckard Oehm, Julia A. Kandenwein, Mathias Mäurer, Stefanie Hieke-Schulz, Tjalf Ziemssen, Patrick Oschmann, Klaus Tiel-Wilck, Vera Zingler, Michael William Springer, Nils Richter
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 12 (2019)
Therapeutic Advances in Neurological Disorders
Therapeutic Advances in Neurological Disorders
Background: With a large array of disease modifying therapies (DMTs) for relapsing-remitting MS (RRMS), identifying the optimal treatment option for the individual patient is challenging and switching of immunotherapies is often required. The objecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a66045315ddef3eb7418522a3bd6c7f
https://doi.org/10.1177/1756286419892077
https://doi.org/10.1177/1756286419892077
Autor:
Ralf A. Linker, Heda Kvakan, David A. Hafler, Dominik N. Müller, Nir Yosef, Jens Titze, Markus Kleinewietfeld, Arndt Manzel
Publikováno v:
Nature. 496:518-522
There has been a marked increase in the incidence of autoimmune diseases in the past half-century. Although the underlying genetic basis of this class of diseases has recently been elucidated, implicating predominantly immune-response genes, changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58997b42acf7a96a0ef4bcf6b2c4a89
https://doi.org/10.1038/nature11868
https://doi.org/10.1038/nature11868
Autor:
Natalia Alenina, Katharina Grave, Lars Christian Rump, Arndt Manzel, De-Hyung Lee, Juliane Friedrich, Michael Bader, Guang Yang, Anna Hammer, Dominik N. Müller, Ralf Gold, Ralf A. Linker, Stefanie Jörg, Johannes Stegbauer, Janina Grosch, Jürgen Winkler, Agnes Kovacs
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(49)
Recently, an alternative renin-angiotensin system pathway has been described, which involves binding of angiotensin-(1-7) to its receptor Mas. The Mas axis may counterbalance angiotensin-II-mediated proinflammatory effects, likely by affecting macrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66d27e430ad68a4467bc253e186d8cc
https://pubmed.ncbi.nlm.nih.gov/27872279
https://pubmed.ncbi.nlm.nih.gov/27872279
Autor:
Marcus D. Säemann, Robson A.S. Santos, Michael Bader, Arndt Manzel, Dunja van Oyen, Susan B. Gurley, Johannes J. Kovarik, Ralf A. Linker, Marko Poglitsch, Christopher C. Kaltenecker, Marlies Antlanger, Khalid M. Elased, Eva Königshausen, Oliver Domenig, Johannes Stegbauer, Daisy Motta-Santos, Nadja Grobe
Publikováno v:
Scientific Reports
Cardiovascular and renal pathologies are frequently associated with an activated renin-angiotensin-system (RAS) and increased levels of its main effector and vasoconstrictor hormone angiotensin II (Ang II). Angiotensin-converting-enzyme-2 (ACE2) has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38468e22c37b6e22bd9c1b14fd42081
https://doi.org/10.1038/srep33678
https://doi.org/10.1038/srep33678
Autor:
Aiden Haghikia, Ralf A. Linker, Dominik N. Müller, Ralf Gold, Arndt Manzel, Jan Kissel, Stefanie Jörg, Markus Kleinewietfeld
Publikováno v:
Experimental Neurology
Recently, we have shown that high dietary salt intake aggravates T helper cell (Th) 17 responses and neuroinflammation. Here, we employed in vitro assays for myeloid dendritic cell (mDC) maturation, DC cytokine production, T cell activation and ex vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354801d15e220234b79e5e04b60edb59
https://pubmed.ncbi.nlm.nih.gov/26976739
https://pubmed.ncbi.nlm.nih.gov/26976739
Autor:
Ralf A. Linker, Valentin Schatz, Katrina J. Binger, Arndt Manzel, Norbert Hubner, Florian Lang, Mark D. Wright, Christian Schwartz, Agnes Schroeder, Carola Rintisch, Matthias Gebhardt, Jens Titze, Markus Kleinewietfeld, Matthias Heinig, Jakob Voelkl, Karl F. Hilgers, Jonathan Jantsch, Dominik N. Müller, Wolfgang Neuhofer, David Voehringer, Ralf Dechend
A high intake of dietary salt (NaCl) has been implicated in the development of hypertension, chronic inflammation, and autoimmune diseases. We have recently shown that salt has a proinflammatory effect and boosts the activation of Th17 cells and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad5a0a4371b84ca16eef4b29a1d6101
https://europepmc.org/articles/PMC4639967/
https://europepmc.org/articles/PMC4639967/
Autor:
De-Hyung, Lee, Petra, Steinacker, Silvia, Seubert, Tanja, Turnescu, Arthur, Melms, Arndt, Manzel, Markus, Otto, Ralf A, Linker
Publikováno v:
Journal of Neuroinflammation
Background The family of 14-3-3 proteins plays an important role in the regulation of cell survival and death. Here, we investigate the role of the 14-3-3 gamma (14-3-3 γ) subunit for glial responses in autoimmune demyelination. Methods Expression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6bba319011444f91a07dca64d1579df
https://pubmed.ncbi.nlm.nih.gov/26438180
https://pubmed.ncbi.nlm.nih.gov/26438180