Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis

Autor: Bram W. van Os, Pascal J. H. Kusters, Myrthe den Toom, Linda Beckers, Claudia M. van Tiel, Winnie G. Vos, Elize de Jong, Arnd Kieser, Cindy van Roomen, Christoph J. Binder, Myrthe E. Reiche, Menno P. de Winther, Laura A. Bosmans, Esther Lutgens

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

BackgroundAtherosclerosis is the underlying cause of many cardiovascular diseases, such as myocardial infarction or stroke. B cells, and their production of pro- and anti-atherogenic antibodies, play an important role in atherosclerosis. In B cells,

Externí odkaz: https://doaj.org/article/b457cc8d45844f5ca3e8e23782d56612

The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor.

Autor: Anna Shkoda, Jennifer A Town, Janine Griese, Michael Romio, Hakan Sarioglu, Thomas Knöfel, Fabian Giehler, Arnd Kieser

Publikováno v: PLoS Biology, Vol 10, Iss 8, p e1001376 (2012)

The tumor necrosis factor-receptor-associated factor 2 (TRAF2)- and Nck-interacting kinase (TNIK) is a ubiquitously expressed member of the germinal center kinase family. The TNIK functions in hematopoietic cells and the role of TNIK-TRAF interaction

Externí odkaz: https://doaj.org/article/a79f619f7332437aa3a8c9f9ef747b27

Epstein-Barr virus-driven B cell lymphoma mediated by a unique LMP1-TRAF6 complex

Autor: Fabian Giehler, Michael Ostertag, Thomas Sommermann, Daniel Weidl, Kai Sterz, Helmut Kutz, Stephan Feller, Arie Geerlof, Brigitte Biesinger, Grzegorz Popowicz, Johannes Kirchmair, Arnd Kieser

The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) drives viral B cell transformation and oncogenesis. LMP1's transforming activity depends on its cytoplasmic C-terminal activation region 2 (CTAR2), which induces NF-κB and JNK by engag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c49aa69b05fde27bbf65d7b7894f478
https://doi.org/10.21203/rs.3.rs-1295699/v1

Discovery of Small Molecule CD40–TRAF6 Inhibitors

Autor: Roy Schrijver, Oliver Soehnlein, Claudia M. van Tiel, Tom Seijkens, Barbara Zarzycka, Tina Ritschel, Tilman M. Hackeng, Sander B. Nabuurs, Jochen Grommes, Gert Vriend, Esther Lutgens, Fabian Giehler, Arnd Kieser, Christian Weber, Gerry A. F. Nicolaes

Publikováno v: Journal of Chemical Information and Modeling, 55(2), 294-307. American Chemical Society
Journal of chemical information and modeling, 55(2), 294-307. American Chemical Society
Journal of Chemical Information and Modeling, 55, 2, pp. 294-307
Journal of Chemical Information and Modeling, 55, 294-307

Item does not contain fulltext The CD154-CD40 receptor complex plays a pivotal role in several inflammatory pathways. Attempts to inhibit the formation of this complex have resulted in systemic side effects. Downstream inhibition of the CD40 signalin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f08cd0f10fbe5082265c09cd8195e62
https://doi.org/10.1021/ci500631e

Pursuing different ‘TRADDes’: TRADD signaling induced by TNF-receptor 1 and the Epstein-Barr virus oncoprotein LMP1

Autor: Arnd Kieser

Publikováno v: bchm. 389:1261-1271

The pro-apoptotic tumor necrosis factor (TNF)-receptor 1-associated death domain protein (TRADD) was initially identified as the central signaling adapter molecule of TNF-receptor 1 (TNFR1). Upon stimulation with the pro-inflammatory cytokine TNFα,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4f85abc025a3d6e7c6647aa79e7ab6
https://doi.org/10.1515/bc.2008.144