Dendrogenin A drives LXR to trigger lethal autophagy in cancers

Autor: Gregory Segala, Marion David, Philippe de Medina, Mathias C. Poirot, Nizar Serhan, François Vergez, Aurelie Mougel, Estelle Saland, Kevin Carayon, Julie Leignadier, Nicolas Caron, Maud Voisin, Julia Cherier, Laetitia Ligat, Frederic Lopez, Emmanuel Noguer, Arnaud Rives, Bruno Payré, Talal al Saati, Antonin Lamaziere, Gaëtan Despres, Jean-Marc Lobaccaro, Silvere Baron, Cecile Demur, Fabienne de Toni, Clément Larrue, Helena Boutzen, Fabienne Thomas, Jean-Emmanuel Sarry, Marie Tosolini, Didier Picard, Michel Record, Christian Récher, Marc Poirot, Sandrine Silvente-Poirot

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia.

Externí odkaz: https://doaj.org/article/0e94ef7a2a0944adb3f0ebb1ddc02cb8

HPLC Analysis and Skin Whitening Effects of Umbelliprenin-containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris

Autor: Vito Alessandro Taddeo, Francesco Epifano, Francesca Preziuso, Serena Fiorito, Nicolas Caron, Arnaud Rives, Philippe de Medina, Marc Poirot, Sandrine Silvente-Poirot, Salvatore Genovese

Publikováno v: Molecules, Vol 24, Iss 3, p 501 (2019)

Umbelliprenin has recently been shown to have great potential as a skin whitening agent. Wishing to investigate the same effect in plant species known to biosynthesize this coumarin, three plants belonging to the Apiaceae family, namely Anethum grave

Externí odkaz: https://doaj.org/article/a3f38b3ec40b4da3b2b7ed73a3076b6c

Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo

Autor: Nizar, Serhan, Pierre-Luc, Mouchel, Philippe de, Medina, Gregory, Segala, Aurélie, Mougel, Estelle, Saland, Arnaud, Rives, Antonin, Lamaziere, Gaëtan, Despres, Jean-Emmanuel, Sarry, Clément, Larrue, François, Vergez, Laetitia, Largeaud, Michel, Record, Christian, Récher, Sandrine, Silvente-Poirot, Marc, Poirot

Publikováno v: Cancers
Cancers, MDPI, 2020, 12 (7), pp.1725. ⟨10.3390/cancers12071725⟩
Cancers, 2020, 12 (7), pp.1725. ⟨10.3390/cancers12071725⟩
Cancers, Vol 12, Iss 1725, p 1725 (2020)

International audience; Dendrogenin A (DDA) is a mammalian cholesterol metabolite that displays potent antitumor properties on acute myeloid leukemia (AML). DDA triggers lethal autophagy in cancer cells through a biased activation of the oxysterol re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8c4a9c27bcb16b02f17ff4015a300483
https://www.hal.inserm.fr/inserm-03084638

A fast UPLC–HILIC method for an accurate quantification of dendrogenin A in human tissues

Autor: Regis Soules, Etienne Chatelut, Fabien Audouard-Combe, Marc Poirot, Ben Allal, Arnaud Rives, Sandrine Silvente-Poirot, Camille Franchet, Philippe de Medina, Emilie Huc-Claustre, Florence Dalenc

Publikováno v: The Journal of steroid biochemistry and molecular biology
The Journal of steroid biochemistry and molecular biology, 2019, 194, pp.105447. ⟨10.1016/j.jsbmb.2019.105447⟩
Journal of Steroid Biochemistry and Molecular Biology
Journal of Steroid Biochemistry and Molecular Biology, 2019, 194, pp.105447. ⟨10.1016/j.jsbmb.2019.105447⟩
Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 2019, 194, pp.105447. ⟨10.1016/j.jsbmb.2019.105447⟩

International audience; Dendrogenin A (DDA) is a newly-discovered steroidal alkaloid, which remains to date the first ever found in mammals. DDA is a cholesterol metabolites that induces cancer cell differentiation and death in vitro and in vivo, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1df5add03334e23f67e0c80dc3c7fc
https://www.hal.inserm.fr/inserm-02380551/file/1-s2.0-S0960076019301633-main-1.pdf

Natural and semisynthetic oxyprenylated aromatic compounds as stimulators or inhibitors of melanogenesis

Autor: Philippe de Medina, Nicolas Caron, Francesco Epifano, Sandrine Silvente-Poirot, Serena Fiorito, Arnaud Rives, Salvatore Genovese, Marc Poirot

Publikováno v: Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2019, 87, pp.181-190. ⟨10.1016/j.bioorg.2019.03.026⟩
Bioorganic Chemistry, 2019, 87, pp.181-190. ⟨10.1016/j.bioorg.2019.03.026⟩

International audience; It has been very recently shown how naturally occurring oxyprenylated coumarins are effective modulators of melanogenesis. In this short communication we wish to generalize the potentialities as skin tanning or whitening agent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbaebafbcc78214fef5048213740934
https://www.hal.inserm.fr/inserm-02380542/file/1-s2.0-S0960076019301694-main.pdf