Missense mutation of VKORC1 leads to medial arterial calcification in rats

Autor: Arnaud Michaux, Benjamin Matagrin, Jean-Valéry Debaux, Leon J. Schurgers, Etienne Benoit, Virginie Lattard

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Abstract Vitamin K plays a crucial role in the regulation of vascular calcifications by allowing activation of matrix Gla protein. The dietary requirement for vitamin K is low because of an efficient recycling of vitamin K by vitamin K epoxide reduct

Externí odkaz: https://doaj.org/article/522f54e8dff545d79a3fde7d87d7e393

Abstract 10461: Totum-854 Lowers Blood Pressure in L-NAME-Induced Arterial Hypertension in Mice and in Spontaneous Hypertensive Rat Model

Autor: Gaetan Bolea, Doriane Ripoche, Gregory MEYER, Florian Le Joubioux, Arnaud Michaux, Yolanda F OTERO, Sébastien PELTIER, Pascal SIRVENT, Cyril REBOUL

Publikováno v: Circulation. 144

Introduction: Arterial Hypertension (AHT) is a major cause of premature death worldwide. We have developed Totum-854 (T-854), a polyphenol-rich botanical composition to reduce the risk of developing AHT. We assessed the chronic effect of T-854 on pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75d7a6d2dcdca93ca9fadeeffa19c34e
https://doi.org/10.1161/circ.144.suppl_1.10461

TOTUM-854 PREVENTS L-NAME-INDUCED ARTERIAL HYPERTENSION IN MICE

Autor: Yolanda F. Otero, Florian Lejoubioux, Pascal Sirvent, Arnaud Michaux, Grégory Meyer, Doriane Ripoche, Cyril Reboul, Gaetan Bolea, Sébastien Peltier

Publikováno v: Journal of Hypertension. 39:e393

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d0ec609575d36a1523a6f5415b69a4d
https://doi.org/10.1097/01.hjh.0000749120.67773.cb

Identification of Key Functional Residues in the Active Site of Vitamin K Epoxide Reductase-like Protein (VKORC1L1)

Autor: Ahmed Hodroge, Benjamin Matagrin, Arnaud Michaux, Etienne Benoit, Abdessalem Hammed, Virginie Lattard

Publikováno v: Biochemistry & Molecular Biology Journal
Biochemistry & Molecular Biology Journal, Insight Medical Publishing, 2016, 2 (3), pp.15. ⟨10.21767/2471-8084.100024⟩
Biochemistry & Molecular Biology Journal, Insight Medical Publishing, 2016, 2 (3), pp.15. 〈http://biochem-molbio.imedpub.com/identification-of-key-functional-residues-in-the-active-site-of-vitamin-k-epoxide-reductaselike-protein-vkorc1l1.php?aid=17851〉. 〈10.21767/2471-8084.100024〉

Background/Purpose: Vitamin K is involved in the gamma-carboxylation of the vitamin K dependent proteins. Due to the limited intake of vitamin K, its regeneration is necessary and involves the vitamin K 2,3-epoxide reductase (VKOR) activity. This act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78948d91e5c007bddac709c869abfbd
https://hal.archives-ouvertes.fr/hal-01564764/file/identification-of-key-functional-residues-in-the-active-site-of-vitamin-k-epoxide-reductaselike-protein-vkorc1l1.pdf

Inhibitory Potential of α-Amylase, α-Glucosidase, and Pancreatic Lipase by a Formulation of Five Plant Extracts: TOTUM-63.

Autor: Haguet, Quentin¹ (AUTHOR), Le Joubioux, Florian² (AUTHOR) florian.lejoubioux@valbiotis.com, Chavanelle, Vivien³ (AUTHOR), Groult, Hugo¹ (AUTHOR), Schoonjans, Nathan² (AUTHOR), Langhi, Cédric³ (AUTHOR), Michaux, Arnaud³ (AUTHOR), Otero, Yolanda F.³ (AUTHOR), Boisseau, Nathalie⁴ (AUTHOR), Peltier, Sébastien L.² (AUTHOR), Sirvent, Pascal³ (AUTHOR), Maugard, Thierry¹ (AUTHOR) florian.lejoubioux@valbiotis.com

Publikováno v: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3652. 19p.