Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Arnaud Le Tiran"'
Autor:
Jianglin Liang, Robert J. Davies, James P. Griffith, Hardwin O'dowd, Cameron Stuver Moody, Elaine Krueger, Philip N. Collier, Yusheng Liao, Upul K. Bandarage, Alex Aronov, Jian Wang, Jingrong Cao, Derek B. Lowe, Veronique Damagnez, Elaine Y. Chin, John D. Doran, Emmanuelle Sizensky, Wojciech Dworakowski, Sudipta Mahajan, David D. Deininger, Marc Jacobs, Jinwang Xu, Arnaud Le Tiran, Suvarna Khare-Pandit, Albert C. Pierce, Suganthi Nanthakumar, Ron Grey, David Messersmith, James A. Henderson, Jon H. Come
Publikováno v:
Journal of Medicinal Chemistry. 61:5245-5256
The lipid kinase phosphoinositide 3-kinase γ (PI3Kγ) has attracted attention as a potential target to treat a variety of autoimmune disorders, including multiple sclerosis, due to its role in immune modulation and microglial activation. By minimizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd9109c79e1ecbf0788c161384fe50c
https://doi.org/10.1021/acs.jmedchem.8b00085
https://doi.org/10.1021/acs.jmedchem.8b00085
Publikováno v:
ACS medicinal chemistry letters. 10(1)
[Image: see text] Phosphoinositide 3-kinase (PI3Kγ) is a drug target that has been implicated in the treatment of a range of diseases. We have developed a synthesis of a novel PI3Kγ inhibitor containing a 1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1b4502bbb615a9c11ce3efd06f24c6
https://pubmed.ncbi.nlm.nih.gov/30655957
https://pubmed.ncbi.nlm.nih.gov/30655957
Autor:
Arnaud Le Tiran, Gaëtan Maertens, Stephen Hanessian, Esat Öney, Sofiane Hocine, Bertrand Goument, Vito Vece, Oscar Mario Saavedra, Miguel A. Vilchis Reyes, Philippe Gloanec, Olivier Mirguet
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(15)
We have developed versatile methods toward the synthesis of a variety of piperidine/piperazine bridged isosteres of pridopidine. The compounds were assessed against the D2 receptor in agonist and antagonist modes and against the D4 receptor in agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0196f7939dd6e0bd353a382626a1a3f3
https://pubmed.ncbi.nlm.nih.gov/29937060
https://pubmed.ncbi.nlm.nih.gov/29937060
Autor:
David Messersmith, Cameron Stuver Moody, Sudipta Mahajan, Yusheng Liao, Upul K. Bandarage, Jinwang Xu, Tiansheng Wang, James P. Griffith, Arnaud Le Tiran, Veronique Damagnez, Elaine Krueger, Setu Roday, Jon H. Come, Kevin M. Cottrell, Brian Ledford, Philip N. Collier, Alex Aronov, Mark W. Ledeboer, Suvarna Khare-Pandit, John D. Doran, Christina Boucher
Publikováno v:
Journal of Medicinal Chemistry. 58:5684-5688
A series of high affinity second-generation thiazolopiperidine inhibitors of PI3Kγ were designed based on some general observations around lipid kinase structure. Optimization of the alkylimidazole group led to inhibitors with higher levels of PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a182fa6e1c15f5980023fc31188413a5
https://doi.org/10.1021/acs.jmedchem.5b00498
https://doi.org/10.1021/acs.jmedchem.5b00498
Autor:
Marc Jacobs, Hardwin O'dowd, Shannon Dean, Paul S. Charifson, Tim Doyle, Trudy H. Grossman, Vaishali Dixit, Brian Boucher, Pan Li, Nigel Ewing, Youssef L. Bennani, Emanuele Perola, Yusheng Liao, Anne-Laure Grillot, Emmanuelle Sizensky, Tiansheng Wang, Lauffer David J, Arnaud Le Tiran, Brian L. Hanzelka, Elaine Krueger, Waal Nathan D, Jerry Tanoury, Shengkai Liao, Steve Ronkin, Qing Tang, Jones Steven
Publikováno v:
Journal of medicinal chemistry. 57(21)
Compound 3 is a potent aminobenzimidazole urea with broad-spectrum Gram-positive antibacterial activity resulting from dual inhibition of bacterial gyrase (GyrB) and topoisomerase IV (ParE), and it demonstrates efficacy in rodent models of bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f6c4d2d96cccf32b7295976d97ca29
https://pubmed.ncbi.nlm.nih.gov/25317480
https://pubmed.ncbi.nlm.nih.gov/25317480
Autor:
Philip N. Collier, David Messersmith, Arnaud Le Tiran, Upul K. Bandarage, Christina Boucher, Jon Come, Kevin M. Cottrell, Veronique Damagnez, John D. Doran, James P. Griffith, Suvarna Khare-Pandit, Elaine B. Krueger, Mark W. Ledeboer, Brian Ledford, Yusheng Liao, Sudipta Mahajan, Cameron S. Moody, Setu Roday, Tiansheng Wang, Jinwang Xu
Publikováno v:
Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 14, p5684-5688, 5p