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pro vyhledávání: '"Arnaud J. Cheguillaume"'
Autor:
Steve Price, Georgette Castanedo, Fernando Padilla, Bohdan Waszkowycz, Christine Chabot, Neil Anthony Pegg, Laurent Salphati, Alan Nadin, Jun Li, Karin Reif, Raj K. Handa, Arnaud J. Cheguillaume, Timothy Hancox, Suzanne Tay, Pascal Savy, Parcharee Tivitmahaisoon, Zachary Kevin Sweeney, Jeremy Murray, Binqing Wei, Krintel Sussie Lerche, Qin Yue, Eileen Mary Seward, Sophie Mukadam, Rama K. Kondru, Pravin Iyer, Sukhjit Sohal, Jasmit Kaur, John Lesnick, Yung-Hsiang Chen, Daniel P. Sutherlin, Stephen J. Shuttleworth, Matthew W. Cartwright, Bindu Goyal, Paul M. Blaney, Paul Goldsmith, Jodie Pang, Matthew C. Lucas, Stewart J. Baker, Jim Nonomiya, Cristina Lewis, Wylie Solang Palmer, Chenghong Zhang, Brian Safina, Matt Baumgardner, Bryan K. Chan, David Michael Goldstein, Jane R. Kenny
Publikováno v:
Journal of medicinal chemistry. 55(12)
PI3Kδ is a lipid kinase and a member of a larger family of enzymes, PI3K class IA(α, β, δ) and IB (γ), which catalyze the phosphorylation of PIP2 to PIP3. PI3Kδ is mainly expressed in leukocytes, where it plays a critical, nonredundant role in